Tags

Type your tag names separated by a space and hit enter

Relationship between serum insulin-like growth factor-1 levels and Alzheimer's disease and vascular dementia.
J Am Geriatr Soc. 2005 Oct; 53(10):1748-53.JA

Abstract

OBJECTIVES

To determine whether decreased serum insulin-like growth factor-1 (IGF-1) levels could be a risk factor for dementia in older people.

DESIGN

Case control study.

SETTING

Showa University Karasuyama Hospital, Tokyo, Japan.

PARTICIPANTS

A total of 436 Japanese elderly subjects: 106 patients with Alzheimer's disease (AD), 103 patients with vascular dementia (VaD), and 227 age-matched controls without dementia.

MEASUREMENTS

Serum concentrations of IGF-1 and atherogenic lipoproteins, carotid artery intima-media thickness (IMT), and plaques were determined.

RESULTS

Mini-Mental State Examination (MMSE) scores were positively correlated with serum IGF-1 concentrations as well as mean blood pressure or body mass index and were negatively correlated with age, serum low-density lipoprotein cholesterol and lipoprotein(a) concentrations, and carotid IMT. Serum IGF-1 concentrations had a significant inverse correlation with carotid IMT. Analysis across the IGF-1 quartiles revealed a threshold effect of low IGF-1 on MMSE score in subjects with the IGF-1 levels of 140 ng/mL or less (50% percentile) versus those with IGF-1 levels greater than 140 ng/mL. Multiple logistic regression concerning AD and VaD retained serum IGF-1 concentrations of 140 ng/mL or less and carotid IMT of 0.9 mm or more. Patients with AD and VaD had significantly lower IGF-1 concentrations and greater mean IMT than nondemented controls.

CONCLUSION

These results suggest that decreased serum IGF-1 level and the progression of carotid atherosclerosis could play a role as independent risk factors for dementia.

Authors+Show Affiliations

Department of Biochemistry, Showa University School of Medicine, Tokyo, Japan. watanabemd@med.showa-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16181175

Citation

Watanabe, Takuya, et al. "Relationship Between Serum Insulin-like Growth Factor-1 Levels and Alzheimer's Disease and Vascular Dementia." Journal of the American Geriatrics Society, vol. 53, no. 10, 2005, pp. 1748-53.
Watanabe T, Miyazaki A, Katagiri T, et al. Relationship between serum insulin-like growth factor-1 levels and Alzheimer's disease and vascular dementia. J Am Geriatr Soc. 2005;53(10):1748-53.
Watanabe, T., Miyazaki, A., Katagiri, T., Yamamoto, H., Idei, T., & Iguchi, T. (2005). Relationship between serum insulin-like growth factor-1 levels and Alzheimer's disease and vascular dementia. Journal of the American Geriatrics Society, 53(10), 1748-53.
Watanabe T, et al. Relationship Between Serum Insulin-like Growth Factor-1 Levels and Alzheimer's Disease and Vascular Dementia. J Am Geriatr Soc. 2005;53(10):1748-53. PubMed PMID: 16181175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between serum insulin-like growth factor-1 levels and Alzheimer's disease and vascular dementia. AU - Watanabe,Takuya, AU - Miyazaki,Akira, AU - Katagiri,Takashi, AU - Yamamoto,Hideki, AU - Idei,Tsunenori, AU - Iguchi,Takashi, PY - 2005/9/27/pubmed PY - 2006/1/13/medline PY - 2005/9/27/entrez SP - 1748 EP - 53 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 53 IS - 10 N2 - OBJECTIVES: To determine whether decreased serum insulin-like growth factor-1 (IGF-1) levels could be a risk factor for dementia in older people. DESIGN: Case control study. SETTING: Showa University Karasuyama Hospital, Tokyo, Japan. PARTICIPANTS: A total of 436 Japanese elderly subjects: 106 patients with Alzheimer's disease (AD), 103 patients with vascular dementia (VaD), and 227 age-matched controls without dementia. MEASUREMENTS: Serum concentrations of IGF-1 and atherogenic lipoproteins, carotid artery intima-media thickness (IMT), and plaques were determined. RESULTS: Mini-Mental State Examination (MMSE) scores were positively correlated with serum IGF-1 concentrations as well as mean blood pressure or body mass index and were negatively correlated with age, serum low-density lipoprotein cholesterol and lipoprotein(a) concentrations, and carotid IMT. Serum IGF-1 concentrations had a significant inverse correlation with carotid IMT. Analysis across the IGF-1 quartiles revealed a threshold effect of low IGF-1 on MMSE score in subjects with the IGF-1 levels of 140 ng/mL or less (50% percentile) versus those with IGF-1 levels greater than 140 ng/mL. Multiple logistic regression concerning AD and VaD retained serum IGF-1 concentrations of 140 ng/mL or less and carotid IMT of 0.9 mm or more. Patients with AD and VaD had significantly lower IGF-1 concentrations and greater mean IMT than nondemented controls. CONCLUSION: These results suggest that decreased serum IGF-1 level and the progression of carotid atherosclerosis could play a role as independent risk factors for dementia. SN - 0002-8614 UR - https://www.unboundmedicine.com/medline/citation/16181175/Relationship_between_serum_insulin_like_growth_factor_1_levels_and_Alzheimer's_disease_and_vascular_dementia_ L2 - https://doi.org/10.1111/j.1532-5415.2005.53524.x DB - PRIME DP - Unbound Medicine ER -