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A noninvasive strategy for screening prospective blood donors for anemia.
Transfusion. 2005 Oct; 45(10):1585-92.T

Abstract

BACKGROUND

The reliability of capillary hemoglobin (Hb) as an indicator for eligibility to donate blood is discussed controversially. Therefore, a noninvasive alternative with acceptable predictive values was established and evaluated.

STUDY DESIGN AND METHODS

Donor candidates were selected according to their Hb level. The first donation was performed 6 weeks after this selection step. A venous blood sample was collected from all donors at the end of their donation and a postdonation Hb determination was performed. Donors with acceptable postdonation Hb values were permitted to donate next time without any predonation Hb measurement. Donors with low postdonation Hb values were permitted to donate only after a venous Hb measurement had shown an acceptable value. Sensitivity and specificity were determined by comparing the gold standard (i.e., venous Hb measurement) with the presented method of Hb estimation for 19,534 donors.

RESULTS

Taking the postdonation Hb as an indicator for eligibility saved 97 percent of donors from being tested unnecessarily by capillary Hb measurement. This procedure resulted in a specificity of 92.6 percent and a sensitivity of 37.9 percent for Hb cutoff levels of 135 and 125 g per L for men and women, respectively. The sensitivity increased rapidly to 100 percent for Hb levels below 105 g per L. The average deviation from true Hb level was 6 g per L.

CONCLUSION

The presented noninvasive method distinctly saves time and expenditure without endangering blood donors.

Authors+Show Affiliations

Department of Transfusion Medicine, Eberhard Karls University, Tuebingen, Germany. ramin.lotfi@gmx.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

16181209

Citation

Lotfi, Ramin, et al. "A Noninvasive Strategy for Screening Prospective Blood Donors for Anemia." Transfusion, vol. 45, no. 10, 2005, pp. 1585-92.
Lotfi R, Wernet D, Starke U, et al. A noninvasive strategy for screening prospective blood donors for anemia. Transfusion. 2005;45(10):1585-92.
Lotfi, R., Wernet, D., Starke, U., Northoff, H., & Cassens, U. (2005). A noninvasive strategy for screening prospective blood donors for anemia. Transfusion, 45(10), 1585-92.
Lotfi R, et al. A Noninvasive Strategy for Screening Prospective Blood Donors for Anemia. Transfusion. 2005;45(10):1585-92. PubMed PMID: 16181209.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A noninvasive strategy for screening prospective blood donors for anemia. AU - Lotfi,Ramin, AU - Wernet,Dorothee, AU - Starke,Uwe, AU - Northoff,Hinnak, AU - Cassens,Uwe, PY - 2005/9/27/pubmed PY - 2005/11/8/medline PY - 2005/9/27/entrez SP - 1585 EP - 92 JF - Transfusion JO - Transfusion VL - 45 IS - 10 N2 - BACKGROUND: The reliability of capillary hemoglobin (Hb) as an indicator for eligibility to donate blood is discussed controversially. Therefore, a noninvasive alternative with acceptable predictive values was established and evaluated. STUDY DESIGN AND METHODS: Donor candidates were selected according to their Hb level. The first donation was performed 6 weeks after this selection step. A venous blood sample was collected from all donors at the end of their donation and a postdonation Hb determination was performed. Donors with acceptable postdonation Hb values were permitted to donate next time without any predonation Hb measurement. Donors with low postdonation Hb values were permitted to donate only after a venous Hb measurement had shown an acceptable value. Sensitivity and specificity were determined by comparing the gold standard (i.e., venous Hb measurement) with the presented method of Hb estimation for 19,534 donors. RESULTS: Taking the postdonation Hb as an indicator for eligibility saved 97 percent of donors from being tested unnecessarily by capillary Hb measurement. This procedure resulted in a specificity of 92.6 percent and a sensitivity of 37.9 percent for Hb cutoff levels of 135 and 125 g per L for men and women, respectively. The sensitivity increased rapidly to 100 percent for Hb levels below 105 g per L. The average deviation from true Hb level was 6 g per L. CONCLUSION: The presented noninvasive method distinctly saves time and expenditure without endangering blood donors. SN - 0041-1132 UR - https://www.unboundmedicine.com/medline/citation/16181209/A_noninvasive_strategy_for_screening_prospective_blood_donors_for_anemia_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0041-1132&date=2005&volume=45&issue=10&spage=1585 DB - PRIME DP - Unbound Medicine ER -