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The objective severity assessment of atopic dermatitis (OSAAD) score: validity, reliability and sensitivity in adult patients with atopic dermatitis.
Br J Dermatol 2005; 153(4):767-73BJ

Abstract

BACKGROUND

The Objective Severity Assessment of Atopic Dermatitis (OSAAD) score is a recently developed scale for evaluation of severity of atopic dermatitis, constructed from the assessment of epidermal barrier function, and properties using noninvasive bioengineering methods and computer-assisted estimates of disease extent. The method has been validated for use in infants and children with atopic dermatitis and compared with a referent scoring system.

OBJECTIVES

The aim of the present study was to test the validity, reliability and sensitivity of the OSAAD score as an objective tool for the assessment of the severity of atopic dermatitis in adult patients.

METHODS

Thirty-two adult patients with atopic dermatitis were included in the study. To assess the validity of the OSAAD score we tested it against the Severity Scoring of Atopic Dermatitis (SCORAD) index of the European Task Force on Atopic Dermatitis as a referent clinical severity scale, and the serum levels of interleukin (IL)-16 as a laboratory variable for monitoring the activity of atopic dermatitis. Responsiveness to change was assessed in a longitudinal study comparing OSAAD, SCORAD and serum levels of IL-16 before and after treatment. To test the reliability of the OSAAD score we studied the interobserver variability of the score recorded by three independent board-certified dermatologists in 16 patients and compared it with SCORAD.

RESULTS

We report a significant correlation between the OSAAD and the SCORAD index as an acknowledged referent severity scale. The OSAAD score correlated significantly with the serum levels of IL-16 in the acute stage of atopic dermatitis. In a longitudinal study, the OSAAD score decreased significantly, parallel with improvement of the skin findings and a significant decrease in the SCORAD score and IL-16 serum levels. We report improved interobserver variability for the OSAAD score compared with SCORAD.

CONCLUSIONS

This is the first study validating the OSAAD score as a sensitive and reliable tool for the assessment of the severity of atopic dermatitis in adult patients.

Authors+Show Affiliations

Department of Dermatology and Allergology, Friedrich-Schiller University-Jena, Erfurter Strasse 35, 07740 Jena, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Validation Studies

Language

eng

PubMed ID

16181458

Citation

Angelova-Fischer, I, et al. "The Objective Severity Assessment of Atopic Dermatitis (OSAAD) Score: Validity, Reliability and Sensitivity in Adult Patients With Atopic Dermatitis." The British Journal of Dermatology, vol. 153, no. 4, 2005, pp. 767-73.
Angelova-Fischer I, Bauer A, Hipler UC, et al. The objective severity assessment of atopic dermatitis (OSAAD) score: validity, reliability and sensitivity in adult patients with atopic dermatitis. Br J Dermatol. 2005;153(4):767-73.
Angelova-Fischer, I., Bauer, A., Hipler, U. C., Petrov, I., Kazandjieva, J., Bruckner, T., ... Fluhr, J. W. (2005). The objective severity assessment of atopic dermatitis (OSAAD) score: validity, reliability and sensitivity in adult patients with atopic dermatitis. The British Journal of Dermatology, 153(4), pp. 767-73.
Angelova-Fischer I, et al. The Objective Severity Assessment of Atopic Dermatitis (OSAAD) Score: Validity, Reliability and Sensitivity in Adult Patients With Atopic Dermatitis. Br J Dermatol. 2005;153(4):767-73. PubMed PMID: 16181458.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The objective severity assessment of atopic dermatitis (OSAAD) score: validity, reliability and sensitivity in adult patients with atopic dermatitis. AU - Angelova-Fischer,I, AU - Bauer,A, AU - Hipler,U C, AU - Petrov,I, AU - Kazandjieva,J, AU - Bruckner,T, AU - Diepgen,T, AU - Tsankov,N, AU - Williams,M, AU - Fischer,T W, AU - Elsner,P, AU - Fluhr,J W, PY - 2005/9/27/pubmed PY - 2006/1/13/medline PY - 2005/9/27/entrez SP - 767 EP - 73 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 153 IS - 4 N2 - BACKGROUND: The Objective Severity Assessment of Atopic Dermatitis (OSAAD) score is a recently developed scale for evaluation of severity of atopic dermatitis, constructed from the assessment of epidermal barrier function, and properties using noninvasive bioengineering methods and computer-assisted estimates of disease extent. The method has been validated for use in infants and children with atopic dermatitis and compared with a referent scoring system. OBJECTIVES: The aim of the present study was to test the validity, reliability and sensitivity of the OSAAD score as an objective tool for the assessment of the severity of atopic dermatitis in adult patients. METHODS: Thirty-two adult patients with atopic dermatitis were included in the study. To assess the validity of the OSAAD score we tested it against the Severity Scoring of Atopic Dermatitis (SCORAD) index of the European Task Force on Atopic Dermatitis as a referent clinical severity scale, and the serum levels of interleukin (IL)-16 as a laboratory variable for monitoring the activity of atopic dermatitis. Responsiveness to change was assessed in a longitudinal study comparing OSAAD, SCORAD and serum levels of IL-16 before and after treatment. To test the reliability of the OSAAD score we studied the interobserver variability of the score recorded by three independent board-certified dermatologists in 16 patients and compared it with SCORAD. RESULTS: We report a significant correlation between the OSAAD and the SCORAD index as an acknowledged referent severity scale. The OSAAD score correlated significantly with the serum levels of IL-16 in the acute stage of atopic dermatitis. In a longitudinal study, the OSAAD score decreased significantly, parallel with improvement of the skin findings and a significant decrease in the SCORAD score and IL-16 serum levels. We report improved interobserver variability for the OSAAD score compared with SCORAD. CONCLUSIONS: This is the first study validating the OSAAD score as a sensitive and reliable tool for the assessment of the severity of atopic dermatitis in adult patients. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/16181458/The_objective_severity_assessment_of_atopic_dermatitis__OSAAD__score:_validity_reliability_and_sensitivity_in_adult_patients_with_atopic_dermatitis_ L2 - https://doi.org/10.1111/j.1365-2133.2005.06697.x DB - PRIME DP - Unbound Medicine ER -