Tags

Type your tag names separated by a space and hit enter

Toxicity and genotoxicity of surface water before and after various potabilization steps.
Mutat Res. 2005 Nov 10; 587(1-2):26-37.MR

Abstract

Many studies have revealed the presence of compounds with genotoxic activity in drinking water by means of short-term mutagenicity tests. In this study, the influence of the different steps of surface water treatment on the mutagenicity of drinking water was evaluated. Four different types of samples were collected: raw lake water, water after pre-disinfection with chlorine dioxide, water after filtration on granular activated carbon, and tap water. Water extracts underwent a bacterial toxicity test (Microtox test) and different in vitro genotoxicity tests: a test with Salmonella typhimurium strains, a Saccharomyces cerevisiae test, the SOS Chromotest with Escherichia coli and the Mutatox test with Vibrio fischeri. The Microtox test revealed high toxicity in the treated water samples. The disinfection steps increased the toxicity: the Mutatox test confirmed these results and the Salmonella/microsome test at the highest doses showed toxicity that could conceal mutagenicity. The SOS Chromotest was positive in all treated water samples without metabolic activation. In the test with S. cerevisiae both toxicity and genotoxicity generally increased during the water treatment steps, especially in cells without induction of cytochrome P450.

Authors+Show Affiliations

Zani C
Department of Applied and Experimental Medicine, University of Brescia, Brescia, Italy.
Feretti D
No affiliation info available
Buschini A
No affiliation info available
Poli P
No affiliation info available
Rossi C
No affiliation info available
Guzzella L
No affiliation info available
Caterino FD
No affiliation info available
Monarca S
No affiliation info available

MeSH

Aliivibrio fischeriCarbonDNA DamageDisinfectionEscherichia coliFiltrationMutagenicity TestsSaccharomyces cerevisiaeSalmonella typhimuriumWater PollutantsWater Purification

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16181804

Citation

Zani, Claudia, et al. "Toxicity and Genotoxicity of Surface Water Before and After Various Potabilization Steps." Mutation Research, vol. 587, no. 1-2, 2005, pp. 26-37.
Zani C, Feretti D, Buschini A, et al. Toxicity and genotoxicity of surface water before and after various potabilization steps. Mutat Res. 2005;587(1-2):26-37.
Zani, C., Feretti, D., Buschini, A., Poli, P., Rossi, C., Guzzella, L., Caterino, F. D., & Monarca, S. (2005). Toxicity and genotoxicity of surface water before and after various potabilization steps. Mutation Research, 587(1-2), 26-37.
Zani C, et al. Toxicity and Genotoxicity of Surface Water Before and After Various Potabilization Steps. Mutat Res. 2005 Nov 10;587(1-2):26-37. PubMed PMID: 16181804.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toxicity and genotoxicity of surface water before and after various potabilization steps. AU - Zani,Claudia, AU - Feretti,Donatella, AU - Buschini,Annamaria, AU - Poli,Paola, AU - Rossi,Carlo, AU - Guzzella,Licia, AU - Caterino,Filomena Di, AU - Monarca,Silvano, Y1 - 2005/09/21/ PY - 2005/03/09/received PY - 2005/06/24/revised PY - 2005/07/16/accepted PY - 2005/9/27/pubmed PY - 2005/12/21/medline PY - 2005/9/27/entrez SP - 26 EP - 37 JF - Mutation research JO - Mutat Res VL - 587 IS - 1-2 N2 - Many studies have revealed the presence of compounds with genotoxic activity in drinking water by means of short-term mutagenicity tests. In this study, the influence of the different steps of surface water treatment on the mutagenicity of drinking water was evaluated. Four different types of samples were collected: raw lake water, water after pre-disinfection with chlorine dioxide, water after filtration on granular activated carbon, and tap water. Water extracts underwent a bacterial toxicity test (Microtox test) and different in vitro genotoxicity tests: a test with Salmonella typhimurium strains, a Saccharomyces cerevisiae test, the SOS Chromotest with Escherichia coli and the Mutatox test with Vibrio fischeri. The Microtox test revealed high toxicity in the treated water samples. The disinfection steps increased the toxicity: the Mutatox test confirmed these results and the Salmonella/microsome test at the highest doses showed toxicity that could conceal mutagenicity. The SOS Chromotest was positive in all treated water samples without metabolic activation. In the test with S. cerevisiae both toxicity and genotoxicity generally increased during the water treatment steps, especially in cells without induction of cytochrome P450. SN - 0027-5107 UR - https://www.unboundmedicine.com/medline/citation/16181804/Toxicity_and_genotoxicity_of_surface_water_before_and_after_various_potabilization_steps_ DB - PRIME DP - Unbound Medicine ER -