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Adolescent development and energy expenditure in females with cystic fibrosis.
Clin Nutr. 2005 Oct; 24(5):737-45.CN

Abstract

BACKGROUND AND AIMS

Poor nutrition and growth status are common in people with cystic fibrosis (CF), and females often have a worse clinical course. Relationships between sexual maturity, nutrition, resting energy expenditure (REE), and pulmonary status in females with CF and pancreatic insufficiency (PI) were evaluated.

METHODS

Pre- and post-menarcheal females with CF and PI (8-29 yr) were compared to healthy females. Z-scores for growth and body composition, anthropometry and DEXA were assessed. REE was measured in all subjects and pulmonary function in CF.

RESULTS

Compared to healthy females (n=28, 14.6+/-4.1 yr), females with CF (n=16, 14.7+/-4.4 yr) had lower height Z (-0.1+/-0.9 versus -0.9+/-0.9, P=0.009) and muscle area Z (0.8+/-1.3 versus -0.4+/-1.2, P=0.007), and higher REE (100+/-10 versus 110+/-11% predicted, P=0.008). Difference in REE was more pronounced for post-menarcheal girls. REE adjusted for fat and fat-free mass was significantly higher with CF (+110 calories/day), and declined with menarcheal age in all subjects. FEV1 was positively associated with BMI Z score, and negatively associated with age at menarche.

CONCLUSIONS

Height and muscle stores were reduced and REE elevated in subjects with CF compared to healthy controls. Poorer growth and nutritional status and delayed menarche were associated with poorer pulmonary function in CF and were likely related to the cumulative effect of energy imbalance on growth and body composition.

Authors+Show Affiliations

Department of Pediatrics, Division of Gastroenterology and Nutrition, The Children's Hospital of Philadelphia, The University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA. stallingsv@email.chop.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16182037

Citation

Stallings, Virginia A., et al. "Adolescent Development and Energy Expenditure in Females With Cystic Fibrosis." Clinical Nutrition (Edinburgh, Scotland), vol. 24, no. 5, 2005, pp. 737-45.
Stallings VA, Tomezsko JL, Schall JI, et al. Adolescent development and energy expenditure in females with cystic fibrosis. Clin Nutr. 2005;24(5):737-45.
Stallings, V. A., Tomezsko, J. L., Schall, J. I., Mascarenhas, M. R., Stettler, N., Scanlin, T. F., & Zemel, B. S. (2005). Adolescent development and energy expenditure in females with cystic fibrosis. Clinical Nutrition (Edinburgh, Scotland), 24(5), 737-45.
Stallings VA, et al. Adolescent Development and Energy Expenditure in Females With Cystic Fibrosis. Clin Nutr. 2005;24(5):737-45. PubMed PMID: 16182037.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adolescent development and energy expenditure in females with cystic fibrosis. AU - Stallings,Virginia A, AU - Tomezsko,Jean L, AU - Schall,Joan I, AU - Mascarenhas,Maria R, AU - Stettler,Nicolas, AU - Scanlin,Thomas F, AU - Zemel,Babette S, Y1 - 2005/04/08/ PY - 2004/09/16/received PY - 2005/02/14/accepted PY - 2005/9/27/pubmed PY - 2006/3/15/medline PY - 2005/9/27/entrez SP - 737 EP - 45 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 24 IS - 5 N2 - BACKGROUND AND AIMS: Poor nutrition and growth status are common in people with cystic fibrosis (CF), and females often have a worse clinical course. Relationships between sexual maturity, nutrition, resting energy expenditure (REE), and pulmonary status in females with CF and pancreatic insufficiency (PI) were evaluated. METHODS: Pre- and post-menarcheal females with CF and PI (8-29 yr) were compared to healthy females. Z-scores for growth and body composition, anthropometry and DEXA were assessed. REE was measured in all subjects and pulmonary function in CF. RESULTS: Compared to healthy females (n=28, 14.6+/-4.1 yr), females with CF (n=16, 14.7+/-4.4 yr) had lower height Z (-0.1+/-0.9 versus -0.9+/-0.9, P=0.009) and muscle area Z (0.8+/-1.3 versus -0.4+/-1.2, P=0.007), and higher REE (100+/-10 versus 110+/-11% predicted, P=0.008). Difference in REE was more pronounced for post-menarcheal girls. REE adjusted for fat and fat-free mass was significantly higher with CF (+110 calories/day), and declined with menarcheal age in all subjects. FEV1 was positively associated with BMI Z score, and negatively associated with age at menarche. CONCLUSIONS: Height and muscle stores were reduced and REE elevated in subjects with CF compared to healthy controls. Poorer growth and nutritional status and delayed menarche were associated with poorer pulmonary function in CF and were likely related to the cumulative effect of energy imbalance on growth and body composition. SN - 0261-5614 UR - https://www.unboundmedicine.com/medline/citation/16182037/Adolescent_development_and_energy_expenditure_in_females_with_cystic_fibrosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(05)00026-9 DB - PRIME DP - Unbound Medicine ER -