Tags

Type your tag names separated by a space and hit enter

Effects of an appropriate oral diet on the nutritional status of patients with HCV-related liver cirrhosis: a prospective study.
Clin Nutr 2005; 24(5):751-9CN

Abstract

BACKGROUND AND AIMS

In patients with liver cirrhosis, protein-energy malnutrition is a frequent finding and a risk factor influencing survival. The aim was to estimate the effects of an adequate diet on malnutrition and clinical outcome in patients with Child A or B HCV-related liver cirrhosis.

METHODS

We enrolled 90 consecutive outpatients (M/F=52/38) with liver cirrhosis, 30 in Child class A and 60 in class B. Patients were evaluated by anamnesis, clinical examination, estimation of daily caloric intake and measurement of anthropometrical and biochemical indexes. Patients were randomized into two groups: group 1 with a 3-month oral controlled diet started one week after the first examination and this was followed by a 3-month of spontaneous dietary intake, and group 2 which started a 3-month spontaneous dietary intake followed by a 3-month of controlled diet. The follow-up was performed every month.

RESULTS

During the period of controlled diet in patients of both groups, protein malnutrition assessed by midarm muscle circumference, creatinine-height index and serum albumin significantly improved independently of the Child class. Lipid malnutrition, assessed by triceps skin fold thickness values, did not improve during the course of the study. The compliance to the prescribed diet was very high in both groups, and no carry over effect of the previous dietary intake was observed during the follow-up period.

CONCLUSIONS

The results emphasize the importance of both nutritional status evaluation and improvement in the Child A and B cirrhotic patients with HCV-related disease. The proposed nutritional approach was able to influence their protein malnutrition positively.

Authors+Show Affiliations

Department of Clinical and Experimental Medicine, Federico II University of Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16182039

Citation

Manguso, F, et al. "Effects of an Appropriate Oral Diet On the Nutritional Status of Patients With HCV-related Liver Cirrhosis: a Prospective Study." Clinical Nutrition (Edinburgh, Scotland), vol. 24, no. 5, 2005, pp. 751-9.
Manguso F, D'Ambra G, Menchise A, et al. Effects of an appropriate oral diet on the nutritional status of patients with HCV-related liver cirrhosis: a prospective study. Clin Nutr. 2005;24(5):751-9.
Manguso, F., D'Ambra, G., Menchise, A., Sollazzo, R., & D'Agostino, L. (2005). Effects of an appropriate oral diet on the nutritional status of patients with HCV-related liver cirrhosis: a prospective study. Clinical Nutrition (Edinburgh, Scotland), 24(5), pp. 751-9.
Manguso F, et al. Effects of an Appropriate Oral Diet On the Nutritional Status of Patients With HCV-related Liver Cirrhosis: a Prospective Study. Clin Nutr. 2005;24(5):751-9. PubMed PMID: 16182039.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of an appropriate oral diet on the nutritional status of patients with HCV-related liver cirrhosis: a prospective study. AU - Manguso,F, AU - D'Ambra,G, AU - Menchise,A, AU - Sollazzo,R, AU - D'Agostino,L, Y1 - 2005/04/07/ PY - 2004/10/10/received PY - 2005/02/23/accepted PY - 2005/9/27/pubmed PY - 2006/3/15/medline PY - 2005/9/27/entrez SP - 751 EP - 9 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 24 IS - 5 N2 - BACKGROUND AND AIMS: In patients with liver cirrhosis, protein-energy malnutrition is a frequent finding and a risk factor influencing survival. The aim was to estimate the effects of an adequate diet on malnutrition and clinical outcome in patients with Child A or B HCV-related liver cirrhosis. METHODS: We enrolled 90 consecutive outpatients (M/F=52/38) with liver cirrhosis, 30 in Child class A and 60 in class B. Patients were evaluated by anamnesis, clinical examination, estimation of daily caloric intake and measurement of anthropometrical and biochemical indexes. Patients were randomized into two groups: group 1 with a 3-month oral controlled diet started one week after the first examination and this was followed by a 3-month of spontaneous dietary intake, and group 2 which started a 3-month spontaneous dietary intake followed by a 3-month of controlled diet. The follow-up was performed every month. RESULTS: During the period of controlled diet in patients of both groups, protein malnutrition assessed by midarm muscle circumference, creatinine-height index and serum albumin significantly improved independently of the Child class. Lipid malnutrition, assessed by triceps skin fold thickness values, did not improve during the course of the study. The compliance to the prescribed diet was very high in both groups, and no carry over effect of the previous dietary intake was observed during the follow-up period. CONCLUSIONS: The results emphasize the importance of both nutritional status evaluation and improvement in the Child A and B cirrhotic patients with HCV-related disease. The proposed nutritional approach was able to influence their protein malnutrition positively. SN - 0261-5614 UR - https://www.unboundmedicine.com/medline/citation/16182039/Effects_of_an_appropriate_oral_diet_on_the_nutritional_status_of_patients_with_HCV_related_liver_cirrhosis:_a_prospective_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(05)00031-2 DB - PRIME DP - Unbound Medicine ER -