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Prenatal screening for fetal face and clefting in a prospective study on low-risk population: can 3- and 4-dimensional ultrasound enhance visualization and detection rate?

Abstract

A study of 1856 second trimester low-risk pregnancies was conducted over a period of 12 months to evaluate the detection rate of cleft lip and palate by 3- and 4-dimensional (3D, 4D) ultrasonography. To image the fetal face and profile, a protocol regarding the use of external or internal hand stimulation or a repeated scan was followed, and the time taken to perform 3D scan was compared to that of a conventional 2D ultrasound. One case of unilateral right cleft lip and a cleft lip plus cleft palate were both identified, giving a prevalence of 1.1 per 1000 live births and a prenatal detection rate of 100%. The average imaging time for fetal face/profile view was significantly less with 3D when compared to 2D (5.33 vs 6.2 seconds, P < .001) and diagnosis at first scan without external or internal hand stimulation was feasible in 78% by 2D versus 87% by 3D technique (P < .0001). Cleft lip and palate were isolated prenatal findings and newborn karyotyping showed normal chromosomal maps in both cases. With the use of this standardized protocol, we were able to image the fetal face and profile view in all cases. We underline the critical role of sonographic expertise in screening for these anomalies and the great enhancement in imaging soft tissues and bone lesions by using 3D ultrasound. We advocate that screening for cleft lip and palate be included in future standard ultrasound examination in the second trimester of pregnancy.

Authors+Show Affiliations

Prenatal Diagnostic Unit, Guastalla Civil Hospital, AUSL Reggio Emilia, Italy.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16182163

Citation

Tonni, Gabriele, et al. "Prenatal Screening for Fetal Face and Clefting in a Prospective Study On Low-risk Population: Can 3- and 4-dimensional Ultrasound Enhance Visualization and Detection Rate?" Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, vol. 100, no. 4, 2005, pp. 420-6.
Tonni G, Centini G, Rosignoli L. Prenatal screening for fetal face and clefting in a prospective study on low-risk population: can 3- and 4-dimensional ultrasound enhance visualization and detection rate? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100(4):420-6.
Tonni, G., Centini, G., & Rosignoli, L. (2005). Prenatal screening for fetal face and clefting in a prospective study on low-risk population: can 3- and 4-dimensional ultrasound enhance visualization and detection rate? Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, 100(4), 420-6.
Tonni G, Centini G, Rosignoli L. Prenatal Screening for Fetal Face and Clefting in a Prospective Study On Low-risk Population: Can 3- and 4-dimensional Ultrasound Enhance Visualization and Detection Rate. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100(4):420-6. PubMed PMID: 16182163.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal screening for fetal face and clefting in a prospective study on low-risk population: can 3- and 4-dimensional ultrasound enhance visualization and detection rate? AU - Tonni,Gabriele, AU - Centini,Giovanni, AU - Rosignoli,Lucia, PY - 2004/10/20/received PY - 2005/01/25/revised PY - 2005/02/23/accepted PY - 2005/9/27/pubmed PY - 2006/2/24/medline PY - 2005/9/27/entrez SP - 420 EP - 6 JF - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod VL - 100 IS - 4 N2 - A study of 1856 second trimester low-risk pregnancies was conducted over a period of 12 months to evaluate the detection rate of cleft lip and palate by 3- and 4-dimensional (3D, 4D) ultrasonography. To image the fetal face and profile, a protocol regarding the use of external or internal hand stimulation or a repeated scan was followed, and the time taken to perform 3D scan was compared to that of a conventional 2D ultrasound. One case of unilateral right cleft lip and a cleft lip plus cleft palate were both identified, giving a prevalence of 1.1 per 1000 live births and a prenatal detection rate of 100%. The average imaging time for fetal face/profile view was significantly less with 3D when compared to 2D (5.33 vs 6.2 seconds, P < .001) and diagnosis at first scan without external or internal hand stimulation was feasible in 78% by 2D versus 87% by 3D technique (P < .0001). Cleft lip and palate were isolated prenatal findings and newborn karyotyping showed normal chromosomal maps in both cases. With the use of this standardized protocol, we were able to image the fetal face and profile view in all cases. We underline the critical role of sonographic expertise in screening for these anomalies and the great enhancement in imaging soft tissues and bone lesions by using 3D ultrasound. We advocate that screening for cleft lip and palate be included in future standard ultrasound examination in the second trimester of pregnancy. SN - 1528-395X UR - https://www.unboundmedicine.com/medline/citation/16182163/Prenatal_screening_for_fetal_face_and_clefting_in_a_prospective_study_on_low_risk_population:_can_3__and_4_dimensional_ultrasound_enhance_visualization_and_detection_rate L2 - https://linkinghub.elsevier.com/retrieve/pii/S1079-2104(05)00205-2 DB - PRIME DP - Unbound Medicine ER -