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Effects of cassia oil on serum and hepatic uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver.
J Ethnopharmacol. 2006 Feb 20; 103(3):357-65.JE

Abstract

We investigated the hypouricemic effects of cassia oil extracted from Cinnamomum cassia using hyperuricemic mice induced by potassium oxonate, and its inhibitory actions against liver xanthine dehydrogenase (XDH) and xanthine oxidase (XOD) activities. Oral administration of cassia oil significantly reduced serum and hepatic urate levels in hyperuricemic mice in a time- and dose-dependent manner. At doses of 450 mg/kg of cassia oil or above, serum urate levels of the oxonate-pretreated mice were not different from the normal control mice. Cassia oil at 600 mg/kg was found to be as potent as allopurinol, which reduced hepatic urate levels to lower than normal. In normal mice, urate levels in liver, but not in serum, were altered with dose-dependent decrease after cassia oil treatment. Furthermore, the ratio, liver uric acid/serum uric acid, was determined after cassia oil administration with time- and dose-dependent decreases in hyperuricemic mice. The positive dose-dependent decrease ratio was also observed after cassia oil treatment in the normal animals. The decreased extent of ratio elicited by cassia oil in normal mice appeared to be greater than that in the hyperuricemic animal. In addition, cassia oil significantly exhibited marked reductions in liver XDH/XOD activities, with an apparent dose-dependence in the normal and hyperuricemic mice. The onset of inhibition in enzyme activities elicited by allopurinol was much higher than that elicited by cassia oil. These results suggested that hypouricemic effects of cassia oil could be explained, at least partly, by inhibiting liver in vivo activities of XDH/XOD.

Authors+Show Affiliations

State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecule, School of Life Sciences, Nanjing University, Nanjing, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16182482

Citation

Zhao, X, et al. "Effects of Cassia Oil On Serum and Hepatic Uric Acid Levels in Oxonate-induced Mice and Xanthine Dehydrogenase and Xanthine Oxidase Activities in Mouse Liver." Journal of Ethnopharmacology, vol. 103, no. 3, 2006, pp. 357-65.
Zhao X, Zhu JX, Mo SF, et al. Effects of cassia oil on serum and hepatic uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver. J Ethnopharmacol. 2006;103(3):357-65.
Zhao, X., Zhu, J. X., Mo, S. F., Pan, Y., & Kong, L. D. (2006). Effects of cassia oil on serum and hepatic uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver. Journal of Ethnopharmacology, 103(3), 357-65.
Zhao X, et al. Effects of Cassia Oil On Serum and Hepatic Uric Acid Levels in Oxonate-induced Mice and Xanthine Dehydrogenase and Xanthine Oxidase Activities in Mouse Liver. J Ethnopharmacol. 2006 Feb 20;103(3):357-65. PubMed PMID: 16182482.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of cassia oil on serum and hepatic uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver. AU - Zhao,X, AU - Zhu,J X, AU - Mo,S F, AU - Pan,Y, AU - Kong,L D, Y1 - 2005/09/22/ PY - 2005/01/06/received PY - 2005/07/29/revised PY - 2005/08/15/accepted PY - 2005/9/27/pubmed PY - 2007/7/31/medline PY - 2005/9/27/entrez SP - 357 EP - 65 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 103 IS - 3 N2 - We investigated the hypouricemic effects of cassia oil extracted from Cinnamomum cassia using hyperuricemic mice induced by potassium oxonate, and its inhibitory actions against liver xanthine dehydrogenase (XDH) and xanthine oxidase (XOD) activities. Oral administration of cassia oil significantly reduced serum and hepatic urate levels in hyperuricemic mice in a time- and dose-dependent manner. At doses of 450 mg/kg of cassia oil or above, serum urate levels of the oxonate-pretreated mice were not different from the normal control mice. Cassia oil at 600 mg/kg was found to be as potent as allopurinol, which reduced hepatic urate levels to lower than normal. In normal mice, urate levels in liver, but not in serum, were altered with dose-dependent decrease after cassia oil treatment. Furthermore, the ratio, liver uric acid/serum uric acid, was determined after cassia oil administration with time- and dose-dependent decreases in hyperuricemic mice. The positive dose-dependent decrease ratio was also observed after cassia oil treatment in the normal animals. The decreased extent of ratio elicited by cassia oil in normal mice appeared to be greater than that in the hyperuricemic animal. In addition, cassia oil significantly exhibited marked reductions in liver XDH/XOD activities, with an apparent dose-dependence in the normal and hyperuricemic mice. The onset of inhibition in enzyme activities elicited by allopurinol was much higher than that elicited by cassia oil. These results suggested that hypouricemic effects of cassia oil could be explained, at least partly, by inhibiting liver in vivo activities of XDH/XOD. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/16182482/Effects_of_cassia_oil_on_serum_and_hepatic_uric_acid_levels_in_oxonate_induced_mice_and_xanthine_dehydrogenase_and_xanthine_oxidase_activities_in_mouse_liver_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(05)00579-9 DB - PRIME DP - Unbound Medicine ER -