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Body composition assessment in adults with cystic fibrosis: comparison of dual-energy X-ray absorptiometry with skinfolds and bioelectrical impedance analysis.
Nutrition. 2005 Nov-Dec; 21(11-12):1087-94.N

Abstract

OBJECTIVE

We compared body composition measurement in adults with cystic fibrosis (CF) by using non-invasive methods (skinfold thicknesses and bioelectrical impedance analysis [BIA]) with dual-energy X-ray absorptiometry (DXA).

METHODS

Seventy-six adults with CF (mean age 29.9 +/- 7.9 y, mean body mass index 21.5 +/- 2.5 kg/m(2)) were studied. Body composition was measured to calculate fat-free mass (FFM) using DXA, the sum of four skinfold thicknesses, and BIA (predictive equations of Lukaski and of Segal).

RESULTS

Mean FFM values +/- standard deviation measured using DXA were 54.8 +/- 7.3 kg in men and 41.2 +/- 3.9 kg in women. Mean FFM values measured using BIA/Lukaski were 51.5 +/- 7.8 kg in men and 40.4 +/- 4.9 kg in women (P < 0.0005 for men, not significant for women for comparison with DXA). Mean FFM values measured using BIA/Segal were 54.2 +/- 7.5 kg for men and 44.1 +/- 5.9 kg for women (not significant for men, P < 0.0005 for women for comparison with DXA). Mean FFM values measured using skinfolds were significantly higher than those for FFM with DXA (57.2 +/- 7.2 kg in men, 43.3 +/- 4.3 kg in women, P < 0.0005 for comparison with DXA). The 95% limits of agreement with FFM using DXA were, for men and women, respectively, -8.3 to 1.7 kg and -6.4 to 4.8 kg for BIA/Lukaski, -4.8 to 3.6 kg and -3.1 to 8.9 kg for BIA/Segal, and -2.8 to 7.3 kg and -1.5 to 5.7 kg for skinfolds.

CONCLUSION

This study suggests that skinfold thickness measurements and BIA will incorrectly estimate FFM in many adults with CF compared with DXA measurements of FFM. These methods have limited application in the assessment of body composition in individual adult patients with CF.

Authors+Show Affiliations

Department of Medicine, Monash University, Alfred Hospital, Melbourne, Victoria, Australia. susannah.king@med.monash.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16183254

Citation

King, Susannah, et al. "Body Composition Assessment in Adults With Cystic Fibrosis: Comparison of Dual-energy X-ray Absorptiometry With Skinfolds and Bioelectrical Impedance Analysis." Nutrition (Burbank, Los Angeles County, Calif.), vol. 21, no. 11-12, 2005, pp. 1087-94.
King S, Wilson J, Kotsimbos T, et al. Body composition assessment in adults with cystic fibrosis: comparison of dual-energy X-ray absorptiometry with skinfolds and bioelectrical impedance analysis. Nutrition. 2005;21(11-12):1087-94.
King, S., Wilson, J., Kotsimbos, T., Bailey, M., & Nyulasi, I. (2005). Body composition assessment in adults with cystic fibrosis: comparison of dual-energy X-ray absorptiometry with skinfolds and bioelectrical impedance analysis. Nutrition (Burbank, Los Angeles County, Calif.), 21(11-12), 1087-94.
King S, et al. Body Composition Assessment in Adults With Cystic Fibrosis: Comparison of Dual-energy X-ray Absorptiometry With Skinfolds and Bioelectrical Impedance Analysis. Nutrition. 2005;21(11-12):1087-94. PubMed PMID: 16183254.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body composition assessment in adults with cystic fibrosis: comparison of dual-energy X-ray absorptiometry with skinfolds and bioelectrical impedance analysis. AU - King,Susannah, AU - Wilson,John, AU - Kotsimbos,Tom, AU - Bailey,Michael, AU - Nyulasi,Ibolya, Y1 - 2005/09/23/ PY - 2004/08/31/received PY - 2005/04/04/accepted PY - 2005/9/27/pubmed PY - 2006/3/17/medline PY - 2005/9/27/entrez SP - 1087 EP - 94 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 21 IS - 11-12 N2 - OBJECTIVE: We compared body composition measurement in adults with cystic fibrosis (CF) by using non-invasive methods (skinfold thicknesses and bioelectrical impedance analysis [BIA]) with dual-energy X-ray absorptiometry (DXA). METHODS: Seventy-six adults with CF (mean age 29.9 +/- 7.9 y, mean body mass index 21.5 +/- 2.5 kg/m(2)) were studied. Body composition was measured to calculate fat-free mass (FFM) using DXA, the sum of four skinfold thicknesses, and BIA (predictive equations of Lukaski and of Segal). RESULTS: Mean FFM values +/- standard deviation measured using DXA were 54.8 +/- 7.3 kg in men and 41.2 +/- 3.9 kg in women. Mean FFM values measured using BIA/Lukaski were 51.5 +/- 7.8 kg in men and 40.4 +/- 4.9 kg in women (P < 0.0005 for men, not significant for women for comparison with DXA). Mean FFM values measured using BIA/Segal were 54.2 +/- 7.5 kg for men and 44.1 +/- 5.9 kg for women (not significant for men, P < 0.0005 for women for comparison with DXA). Mean FFM values measured using skinfolds were significantly higher than those for FFM with DXA (57.2 +/- 7.2 kg in men, 43.3 +/- 4.3 kg in women, P < 0.0005 for comparison with DXA). The 95% limits of agreement with FFM using DXA were, for men and women, respectively, -8.3 to 1.7 kg and -6.4 to 4.8 kg for BIA/Lukaski, -4.8 to 3.6 kg and -3.1 to 8.9 kg for BIA/Segal, and -2.8 to 7.3 kg and -1.5 to 5.7 kg for skinfolds. CONCLUSION: This study suggests that skinfold thickness measurements and BIA will incorrectly estimate FFM in many adults with CF compared with DXA measurements of FFM. These methods have limited application in the assessment of body composition in individual adult patients with CF. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/16183254/Body_composition_assessment_in_adults_with_cystic_fibrosis:_comparison_of_dual_energy_X_ray_absorptiometry_with_skinfolds_and_bioelectrical_impedance_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(05)00218-2 DB - PRIME DP - Unbound Medicine ER -