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Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview.

Abstract

According to the free radical theory, aging can be considered as a progressive, inevitable process partially related to the accumulation of oxidative damage into biomolecules -- nucleic acids, lipids, proteins or carbohydrates -- due to an imbalance between prooxidants and antioxidants in favor of the former. More recently also the pathogenesis of several diseases has been linked to a condition of oxidative stress. In this review we focus our attention on the evidence of oxidative stress in aging brain, some of the most important neurodegenerative diseases -- Alzheimer's disease (AD), mild cognitive impairment (MCI), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD) -- and in two common and highly disabling vascular pathologies--stroke and cardiac failure. Particular attention will be given to the current knowledge about the biomarkers of oxidative stress that can be possibly used to monitor their severity and outcome.

Authors+Show Affiliations

Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce-Padiglione E, Via Brunamonti 51, 06122 Perugia Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16183338

Citation

Mariani, E, et al. "Oxidative Stress in Brain Aging, Neurodegenerative and Vascular Diseases: an Overview." Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, vol. 827, no. 1, 2005, pp. 65-75.
Mariani E, Polidori MC, Cherubini A, et al. Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview. J Chromatogr B Analyt Technol Biomed Life Sci. 2005;827(1):65-75.
Mariani, E., Polidori, M. C., Cherubini, A., & Mecocci, P. (2005). Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 827(1), pp. 65-75.
Mariani E, et al. Oxidative Stress in Brain Aging, Neurodegenerative and Vascular Diseases: an Overview. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Nov 15;827(1):65-75. PubMed PMID: 16183338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview. AU - Mariani,E, AU - Polidori,M C, AU - Cherubini,A, AU - Mecocci,P, Y1 - 2005/09/23/ PY - 2005/02/18/received PY - 2005/04/11/revised PY - 2005/04/28/accepted PY - 2005/9/27/pubmed PY - 2006/2/1/medline PY - 2005/9/27/entrez SP - 65 EP - 75 JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences JO - J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. VL - 827 IS - 1 N2 - According to the free radical theory, aging can be considered as a progressive, inevitable process partially related to the accumulation of oxidative damage into biomolecules -- nucleic acids, lipids, proteins or carbohydrates -- due to an imbalance between prooxidants and antioxidants in favor of the former. More recently also the pathogenesis of several diseases has been linked to a condition of oxidative stress. In this review we focus our attention on the evidence of oxidative stress in aging brain, some of the most important neurodegenerative diseases -- Alzheimer's disease (AD), mild cognitive impairment (MCI), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD) -- and in two common and highly disabling vascular pathologies--stroke and cardiac failure. Particular attention will be given to the current knowledge about the biomarkers of oxidative stress that can be possibly used to monitor their severity and outcome. SN - 1570-0232 UR - https://www.unboundmedicine.com/medline/citation/16183338/Oxidative_stress_in_brain_aging_neurodegenerative_and_vascular_diseases:_an_overview_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1570-0232(05)00304-1 DB - PRIME DP - Unbound Medicine ER -