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Obesity and prevalent and incident CKD: the Hypertension Detection and Follow-Up Program.
Am J Kidney Dis. 2005 Oct; 46(4):587-94.AJ

Abstract

BACKGROUND

Obesity is associated with increased single-nephron glomerular filtration rate, which may increase the risk for chronic kidney disease (CKD), especially when combined with hypertension. However, epidemiological data supporting an association between overweight and obesity and risk for CKD currently are limited.

METHODS

We used data from the Hypertension Detection and Follow-Up Program (HDFP) to test the hypothesis that overweight and obesity are associated with incident CKD in 5,897 hypertensive adults. Serum and spot urine samples were collected at baseline and year 5. CKD is defined as the presence of 1+ or greater proteinuria on routine urinalysis and/or an estimated glomerular filtration rate less than 60 mL/min/1.73 m2 (<1.0 mL/s).

RESULTS

In HDFP participants without CKD at baseline, the incidence of CKD at year 5 was 28% in the ideal-body-mass-index group, 31% in the overweight group, and 34% in the obese group. After adjustment for all covariates, including diabetes mellitus, mean baseline diastolic blood pressure, and slope of diastolic blood pressure, both baseline overweight (odds ratio [OR], 1.21; 95% confidence interval [CI], 1.05 to 1.41) and obesity (OR, 1.40; 95% CI, 1.20 to 1.63) were associated with increased odds of incident CKD at year 5. Similar results were noted after exclusion of participants with baseline diabetes mellitus, with both overweight (OR, 1.22; 95% CI, 1.05 to 1.43) and obesity (OR, 1.38; 95% CI, 1.17 to 1.63) remaining significantly associated with incident CKD.

CONCLUSION

These results suggest that obese adults with hypertension have an increased risk for CKD.

Authors+Show Affiliations

Department of Preventive Medicine, Loyola Medical Center, Maywood, IL 60153, USA. hkramer@lumc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16183412

Citation

Kramer, Holly, et al. "Obesity and Prevalent and Incident CKD: the Hypertension Detection and Follow-Up Program." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, vol. 46, no. 4, 2005, pp. 587-94.
Kramer H, Luke A, Bidani A, et al. Obesity and prevalent and incident CKD: the Hypertension Detection and Follow-Up Program. Am J Kidney Dis. 2005;46(4):587-94.
Kramer, H., Luke, A., Bidani, A., Cao, G., Cooper, R., & McGee, D. (2005). Obesity and prevalent and incident CKD: the Hypertension Detection and Follow-Up Program. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, 46(4), 587-94.
Kramer H, et al. Obesity and Prevalent and Incident CKD: the Hypertension Detection and Follow-Up Program. Am J Kidney Dis. 2005;46(4):587-94. PubMed PMID: 16183412.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obesity and prevalent and incident CKD: the Hypertension Detection and Follow-Up Program. AU - Kramer,Holly, AU - Luke,Amy, AU - Bidani,Anil, AU - Cao,Guichan, AU - Cooper,Richard, AU - McGee,Dan, PY - 2005/03/29/received PY - 2005/06/06/accepted PY - 2005/9/27/pubmed PY - 2005/11/4/medline PY - 2005/9/27/entrez SP - 587 EP - 94 JF - American journal of kidney diseases : the official journal of the National Kidney Foundation JO - Am J Kidney Dis VL - 46 IS - 4 N2 - BACKGROUND: Obesity is associated with increased single-nephron glomerular filtration rate, which may increase the risk for chronic kidney disease (CKD), especially when combined with hypertension. However, epidemiological data supporting an association between overweight and obesity and risk for CKD currently are limited. METHODS: We used data from the Hypertension Detection and Follow-Up Program (HDFP) to test the hypothesis that overweight and obesity are associated with incident CKD in 5,897 hypertensive adults. Serum and spot urine samples were collected at baseline and year 5. CKD is defined as the presence of 1+ or greater proteinuria on routine urinalysis and/or an estimated glomerular filtration rate less than 60 mL/min/1.73 m2 (<1.0 mL/s). RESULTS: In HDFP participants without CKD at baseline, the incidence of CKD at year 5 was 28% in the ideal-body-mass-index group, 31% in the overweight group, and 34% in the obese group. After adjustment for all covariates, including diabetes mellitus, mean baseline diastolic blood pressure, and slope of diastolic blood pressure, both baseline overweight (odds ratio [OR], 1.21; 95% confidence interval [CI], 1.05 to 1.41) and obesity (OR, 1.40; 95% CI, 1.20 to 1.63) were associated with increased odds of incident CKD at year 5. Similar results were noted after exclusion of participants with baseline diabetes mellitus, with both overweight (OR, 1.22; 95% CI, 1.05 to 1.43) and obesity (OR, 1.38; 95% CI, 1.17 to 1.63) remaining significantly associated with incident CKD. CONCLUSION: These results suggest that obese adults with hypertension have an increased risk for CKD. SN - 1523-6838 UR - https://www.unboundmedicine.com/medline/citation/16183412/Obesity_and_prevalent_and_incident_CKD:_the_Hypertension_Detection_and_Follow_Up_Program_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0272-6386(05)00853-X DB - PRIME DP - Unbound Medicine ER -