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Oral contraceptive use and risk of breast cancer among women with a family history of breast cancer: a prospective cohort study.
Cancer Causes Control. 2005 Nov; 16(9):1059-63.CC

Abstract

Family history of breast cancer is an established risk factor for breast cancer. In addition, there is evidence that oral contraceptive use may be associated with a moderate increase in breast cancer risk. The three cohort studies that have investigated the relationship between oral contraceptive use and breast cancer risk among women with a family history of breast cancer have yielded mixed results, possibly due to the relatively small sample sizes employed and/or differences in the selection of covariates for inclusion in multivariate models. Therefore, we examined the association between oral contraceptive use and breast cancer risk in a large cohort study in Canada. The cohort consisted of the 27,318 women in the Canadian National Breast Screening Study who reported a family history of breast cancer on enrollment into the study. Linkages to national mortality and cancer databases yielded data on deaths and cancer incidence, with follow-up ending between 1998 and 2000, depending upon the province. During a mean of 16.0 years of follow-up, we observed 1707 incident cases of breast cancer among women with any history of breast cancer of which 795 cases occurred among women with a mother, sister, and/or daughter with breast cancer. Among women with any family history of breast cancer, ever use of oral contraceptives was associated with a 12% reduction in risk of breast cancer (95% confidence interval [CI]=0.73-1.07), and there was an inverse trend with increasing duration of use of borderline statistical significance (p(trend)=0.03). Although we also observed a 25% lower risk of breast cancer associated with oral contraceptive use of greater than 84 months versus never use among women with a first degree relative with breast cancer, this finding was not statistically significant (95% CI=0.47-1.19, p(trend)=0.48). Our data raise the possibility that relatively long duration of oral contraceptive use may be inversely associated with risk among women with a family history of breast cancer.

Authors+Show Affiliations

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY 10461, USA. ssilvera@aecom.yu.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16184471

Citation

Silvera, Stephanie A N., et al. "Oral Contraceptive Use and Risk of Breast Cancer Among Women With a Family History of Breast Cancer: a Prospective Cohort Study." Cancer Causes & Control : CCC, vol. 16, no. 9, 2005, pp. 1059-63.
Silvera SA, Miller AB, Rohan TE. Oral contraceptive use and risk of breast cancer among women with a family history of breast cancer: a prospective cohort study. Cancer Causes Control. 2005;16(9):1059-63.
Silvera, S. A., Miller, A. B., & Rohan, T. E. (2005). Oral contraceptive use and risk of breast cancer among women with a family history of breast cancer: a prospective cohort study. Cancer Causes & Control : CCC, 16(9), 1059-63.
Silvera SA, Miller AB, Rohan TE. Oral Contraceptive Use and Risk of Breast Cancer Among Women With a Family History of Breast Cancer: a Prospective Cohort Study. Cancer Causes Control. 2005;16(9):1059-63. PubMed PMID: 16184471.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral contraceptive use and risk of breast cancer among women with a family history of breast cancer: a prospective cohort study. AU - Silvera,Stephanie A N, AU - Miller,Anthony B, AU - Rohan,Thomas E, PY - 2005/02/07/received PY - 2005/05/09/accepted PY - 2005/9/27/pubmed PY - 2006/1/18/medline PY - 2005/9/27/entrez SP - 1059 EP - 63 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 16 IS - 9 N2 - Family history of breast cancer is an established risk factor for breast cancer. In addition, there is evidence that oral contraceptive use may be associated with a moderate increase in breast cancer risk. The three cohort studies that have investigated the relationship between oral contraceptive use and breast cancer risk among women with a family history of breast cancer have yielded mixed results, possibly due to the relatively small sample sizes employed and/or differences in the selection of covariates for inclusion in multivariate models. Therefore, we examined the association between oral contraceptive use and breast cancer risk in a large cohort study in Canada. The cohort consisted of the 27,318 women in the Canadian National Breast Screening Study who reported a family history of breast cancer on enrollment into the study. Linkages to national mortality and cancer databases yielded data on deaths and cancer incidence, with follow-up ending between 1998 and 2000, depending upon the province. During a mean of 16.0 years of follow-up, we observed 1707 incident cases of breast cancer among women with any history of breast cancer of which 795 cases occurred among women with a mother, sister, and/or daughter with breast cancer. Among women with any family history of breast cancer, ever use of oral contraceptives was associated with a 12% reduction in risk of breast cancer (95% confidence interval [CI]=0.73-1.07), and there was an inverse trend with increasing duration of use of borderline statistical significance (p(trend)=0.03). Although we also observed a 25% lower risk of breast cancer associated with oral contraceptive use of greater than 84 months versus never use among women with a first degree relative with breast cancer, this finding was not statistically significant (95% CI=0.47-1.19, p(trend)=0.48). Our data raise the possibility that relatively long duration of oral contraceptive use may be inversely associated with risk among women with a family history of breast cancer. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/16184471/Oral_contraceptive_use_and_risk_of_breast_cancer_among_women_with_a_family_history_of_breast_cancer:_a_prospective_cohort_study_ L2 - https://doi.org/10.1007/s10552-005-0343-1 DB - PRIME DP - Unbound Medicine ER -