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Intake of selenium in the prevention of prostate cancer: a systematic review and meta-analysis.
Cancer Causes Control 2005; 16(9):1125-31CC

Abstract

BACKGROUND

Recent studies have suggested that selenium intake may prevent the risk of developing prostate cancer. Results from some of these studies have given conflicting results. Because of these discrepant results we sought to explore the association between selenium intake and prostate cancer by conducting a systematic review and meta-analysis of the literature.

METHODS

We systematically searched MEDLINE, EMBASE and Cochrane Library between 1966 and May 2005 for articles that examined the association between intake of selenium and the risk of prostate cancer. We abstracted the data from relevant studies. A random effects model was used to estimate pooled relative risks for both cohort and case-control studies. Heterogeneity was assessed graphically using a Funnel Plot.

RESULTS

Sixteen studies (eleven cohort studies and five case-control studies) were included in the final analysis. The pooled relative risk of prostate cancer for any intake of selenium was 0.72 (0.61-0.84) for cohort studies and 0.74 (0.61-1.39) for case-control studies. The pooled relative risk of moderate intake was 0.74 (0.61-0.90) for cohort studies and 0.74 (0.39-1.39) for case-control studies. A dose-response trend was observed when we stratified the studies by disease severity.

CONCLUSION

The results of our systematic review suggest that selenium intake may reduce the risk of prostate cancer. The results confirm the need for large randomized controlled trials, which are ongoing, to answer this question.

Authors+Show Affiliations

Division of Clinical Epidemiology, Royal Victoria Hospital, 1020 Pine Ave. West, Montreal, Quebec H3A1A2, Canada. metminan@shaw.caNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

16184479

Citation

Etminan, Mahyar, et al. "Intake of Selenium in the Prevention of Prostate Cancer: a Systematic Review and Meta-analysis." Cancer Causes & Control : CCC, vol. 16, no. 9, 2005, pp. 1125-31.
Etminan M, FitzGerald JM, Gleave M, et al. Intake of selenium in the prevention of prostate cancer: a systematic review and meta-analysis. Cancer Causes Control. 2005;16(9):1125-31.
Etminan, M., FitzGerald, J. M., Gleave, M., & Chambers, K. (2005). Intake of selenium in the prevention of prostate cancer: a systematic review and meta-analysis. Cancer Causes & Control : CCC, 16(9), pp. 1125-31.
Etminan M, et al. Intake of Selenium in the Prevention of Prostate Cancer: a Systematic Review and Meta-analysis. Cancer Causes Control. 2005;16(9):1125-31. PubMed PMID: 16184479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of selenium in the prevention of prostate cancer: a systematic review and meta-analysis. AU - Etminan,Mahyar, AU - FitzGerald,J Mark, AU - Gleave,Martin, AU - Chambers,Keith, PY - 2005/01/26/received PY - 2005/06/10/accepted PY - 2005/9/27/pubmed PY - 2006/1/18/medline PY - 2005/9/27/entrez SP - 1125 EP - 31 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 16 IS - 9 N2 - BACKGROUND: Recent studies have suggested that selenium intake may prevent the risk of developing prostate cancer. Results from some of these studies have given conflicting results. Because of these discrepant results we sought to explore the association between selenium intake and prostate cancer by conducting a systematic review and meta-analysis of the literature. METHODS: We systematically searched MEDLINE, EMBASE and Cochrane Library between 1966 and May 2005 for articles that examined the association between intake of selenium and the risk of prostate cancer. We abstracted the data from relevant studies. A random effects model was used to estimate pooled relative risks for both cohort and case-control studies. Heterogeneity was assessed graphically using a Funnel Plot. RESULTS: Sixteen studies (eleven cohort studies and five case-control studies) were included in the final analysis. The pooled relative risk of prostate cancer for any intake of selenium was 0.72 (0.61-0.84) for cohort studies and 0.74 (0.61-1.39) for case-control studies. The pooled relative risk of moderate intake was 0.74 (0.61-0.90) for cohort studies and 0.74 (0.39-1.39) for case-control studies. A dose-response trend was observed when we stratified the studies by disease severity. CONCLUSION: The results of our systematic review suggest that selenium intake may reduce the risk of prostate cancer. The results confirm the need for large randomized controlled trials, which are ongoing, to answer this question. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/16184479/Intake_of_selenium_in_the_prevention_of_prostate_cancer:_a_systematic_review_and_meta_analysis_ L2 - https://doi.org/10.1007/s10552-005-0334-2 DB - PRIME DP - Unbound Medicine ER -