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Endocannabinoids and their involvement in the neurovascular system.
Curr Neurovasc Res 2004; 1(2):129-40CN

Abstract

Endocannabinoids are a new class of lipids, which include amides, esters and ethers of long chain polyunsaturated fatty acids. Anandamide (N-arachidonoylethanolamine; AEA) and 2-arachidonoylglycerol are the main endogenous agonists of cannabinoid receptors, able to mimic several pharmacological effects of Delta(9)-tetrahydrocannabinol, the active principle of Cannabis sativa preparations like hashish and marijuana. It is known that the activity of AEA is limited by cellular uptake through a specific membrane transporter, followed by intracellular degradation by a fatty acid amide hydrolase. Together with AEA and congeners these proteins form the "endocannabinoid system". The endogenous cannabinoids were identified in brain, and also in neuronal and endothelial cells, suggesting a potential role as modulators in the central nervous system and in the periphery. This review summarises the metabolic routes for the synthesis and degradation of AEA, and the latest advances in the involvement of this lipid in neurovascular biology. In addition, the therapeutic potential of the modulation of endocannabinoid metabolism for neuronal and vascular system will be also reviewed.

Authors+Show Affiliations

Department of Biomedical Sciences, University of Teramo, Piazza A. Moro 45, I-64100 Teramo, Italy.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16185189

Citation

Battista, Natalia, et al. "Endocannabinoids and Their Involvement in the Neurovascular System." Current Neurovascular Research, vol. 1, no. 2, 2004, pp. 129-40.
Battista N, Fezza F, Maccarrone M. Endocannabinoids and their involvement in the neurovascular system. Curr Neurovasc Res. 2004;1(2):129-40.
Battista, N., Fezza, F., & Maccarrone, M. (2004). Endocannabinoids and their involvement in the neurovascular system. Current Neurovascular Research, 1(2), pp. 129-40.
Battista N, Fezza F, Maccarrone M. Endocannabinoids and Their Involvement in the Neurovascular System. Curr Neurovasc Res. 2004;1(2):129-40. PubMed PMID: 16185189.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endocannabinoids and their involvement in the neurovascular system. AU - Battista,Natalia, AU - Fezza,Filomena, AU - Maccarrone,Mauro, PY - 2005/9/28/pubmed PY - 2005/12/13/medline PY - 2005/9/28/entrez SP - 129 EP - 40 JF - Current neurovascular research JO - Curr Neurovasc Res VL - 1 IS - 2 N2 - Endocannabinoids are a new class of lipids, which include amides, esters and ethers of long chain polyunsaturated fatty acids. Anandamide (N-arachidonoylethanolamine; AEA) and 2-arachidonoylglycerol are the main endogenous agonists of cannabinoid receptors, able to mimic several pharmacological effects of Delta(9)-tetrahydrocannabinol, the active principle of Cannabis sativa preparations like hashish and marijuana. It is known that the activity of AEA is limited by cellular uptake through a specific membrane transporter, followed by intracellular degradation by a fatty acid amide hydrolase. Together with AEA and congeners these proteins form the "endocannabinoid system". The endogenous cannabinoids were identified in brain, and also in neuronal and endothelial cells, suggesting a potential role as modulators in the central nervous system and in the periphery. This review summarises the metabolic routes for the synthesis and degradation of AEA, and the latest advances in the involvement of this lipid in neurovascular biology. In addition, the therapeutic potential of the modulation of endocannabinoid metabolism for neuronal and vascular system will be also reviewed. SN - 1567-2026 UR - https://www.unboundmedicine.com/medline/citation/16185189/Endocannabinoids_and_their_involvement_in_the_neurovascular_system_ L2 - http://www.eurekaselect.com/62599/article DB - PRIME DP - Unbound Medicine ER -