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[Usefulness of anti-transglutaminase antibodies in the diagnosis of celiac disease].
Gastroenterol Hepatol 2005; 28(8):437-40GH

Abstract

BACKGROUND

Anti-transglutaminase antibodies have been proposed as a useful tool in the diagnosis and follow-up of celiac disease.

AIM

To compare anti-transglutaminase antibodies with the classical antibodies used to diagnose celiac disease.

MATERIAL AND METHOD

Patients who underwent duodenal biopsy for suspected celiac disease were selected if they had the following serum antibody samples: antiendomysial IgA, anti-transglutaminase IgA, antigliadin IgG, and antigliadin IgA. A diagnostic value of each of these antibodies was established according to the final diagnosis, taking the duodenal biopsy as the reference.

RESULTS

One hundred twenty-two patients with duodenal biopsy and serologic markers for celiac disease were selected. Thirty-six patients were children (< 14 years-old) and 86 were adults. A diagnosis of celiac disease was made in 41 patients (26 children and 15 adults). Of the 15 adults, only 2 (13%) presented typical malabsorption syndrome. The sensitivity and specificity of anti-transglutaminase antibodies was 100% and 98% respectively compared with values of 97% and 98% for antiendomysial IgA, 85% and 97% for antigliadin IgA, and 97% and 92% for antigliadin IgG antibodies.

CONCLUSIONS

The diagnostic value of anti-transglutaminase antibodies is high in celiac disease. These antibodies may be useful as a screening test to select candidates for duodenal biopsy.

Authors+Show Affiliations

Sección de Aparato Digestivo, Hospital de León, León, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Evaluation Studies
Journal Article

Language

spa

PubMed ID

16185576

Citation

Fernández, M L., et al. "[Usefulness of Anti-transglutaminase Antibodies in the Diagnosis of Celiac Disease]." Gastroenterologia Y Hepatologia, vol. 28, no. 8, 2005, pp. 437-40.
Fernández ML, Vivas S, Ruiz de Morales JM, et al. [Usefulness of anti-transglutaminase antibodies in the diagnosis of celiac disease]. Gastroenterol Hepatol. 2005;28(8):437-40.
Fernández, M. L., Vivas, S., Ruiz de Morales, J. M., & Marugán, J. M. (2005). [Usefulness of anti-transglutaminase antibodies in the diagnosis of celiac disease]. Gastroenterologia Y Hepatologia, 28(8), pp. 437-40.
Fernández ML, et al. [Usefulness of Anti-transglutaminase Antibodies in the Diagnosis of Celiac Disease]. Gastroenterol Hepatol. 2005;28(8):437-40. PubMed PMID: 16185576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Usefulness of anti-transglutaminase antibodies in the diagnosis of celiac disease]. AU - Fernández,M L, AU - Vivas,S, AU - Ruiz de Morales,J M, AU - Marugán,J M, PY - 2005/9/28/pubmed PY - 2005/12/13/medline PY - 2005/9/28/entrez SP - 437 EP - 40 JF - Gastroenterologia y hepatologia JO - Gastroenterol Hepatol VL - 28 IS - 8 N2 - BACKGROUND: Anti-transglutaminase antibodies have been proposed as a useful tool in the diagnosis and follow-up of celiac disease. AIM: To compare anti-transglutaminase antibodies with the classical antibodies used to diagnose celiac disease. MATERIAL AND METHOD: Patients who underwent duodenal biopsy for suspected celiac disease were selected if they had the following serum antibody samples: antiendomysial IgA, anti-transglutaminase IgA, antigliadin IgG, and antigliadin IgA. A diagnostic value of each of these antibodies was established according to the final diagnosis, taking the duodenal biopsy as the reference. RESULTS: One hundred twenty-two patients with duodenal biopsy and serologic markers for celiac disease were selected. Thirty-six patients were children (< 14 years-old) and 86 were adults. A diagnosis of celiac disease was made in 41 patients (26 children and 15 adults). Of the 15 adults, only 2 (13%) presented typical malabsorption syndrome. The sensitivity and specificity of anti-transglutaminase antibodies was 100% and 98% respectively compared with values of 97% and 98% for antiendomysial IgA, 85% and 97% for antigliadin IgA, and 97% and 92% for antigliadin IgG antibodies. CONCLUSIONS: The diagnostic value of anti-transglutaminase antibodies is high in celiac disease. These antibodies may be useful as a screening test to select candidates for duodenal biopsy. SN - 0210-5705 UR - https://www.unboundmedicine.com/medline/citation/16185576/[Usefulness_of_anti_transglutaminase_antibodies_in_the_diagnosis_of_celiac_disease]_ L2 - http://www.elsevier.es/en/linksolver/ft/ivp/0210-5705/28/437 DB - PRIME DP - Unbound Medicine ER -