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Acid and alkaline phosphatase activities and pathological changes induced in Tilapia fish (Oreochromis sp.) exposed subchronically to microcystins from toxic cyanobacterial blooms under laboratory conditions.
Toxicon. 2005 Dec 01; 46(7):725-35.T

Abstract

The effects of microcystins (MCs) from cyanobacterial cells on the enzymatic activities of acid and alkaline phosphatases (ACP and ALP) from liver, kidney and gill tissues, and the histopathological changes in freshwater Tilapia fish (Oreochromis sp.) were investigated under laboratory conditions. Fish were exposed to cyanobacterial cells (60.0 microg MC-LR/fish per day) through their diet at different exposure times (14 and 21 days). The cells were fed to the fish in two types of oral administration: mixed with a commercial fish food or crushed into a commercial fish food so that the toxins were released. ACP and ALP activities changed in response to MCs in a time-dependent manner, and these changes were more prominent in liver and kidney. The way the MCs were administered had no influence on the biochemical parameters. Similarly, the most severe histopathological changes were observed in the same two organs, although the gills and intestines were also affected. The parenchymal architecture of the liver was dissolved, and round hepatocytes with the appearance of pyknotic nuclei were detected. Kidney lesions consisted of the dilation of Bowman's space and necrotic epithelial cells with pyknotic nuclei in the tubules. These findings suggest that low and repeated doses of MC-LR from cyanobacterial cells induce toxicity in tilapia fish although no adverse effects were detected.

Authors+Show Affiliations

Area de Toxicología, Facultad de Farmacia, C/Profesor García González, n 2, 41012 Sevilla, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16185737

Citation

Molina, R, et al. "Acid and Alkaline Phosphatase Activities and Pathological Changes Induced in Tilapia Fish (Oreochromis Sp.) Exposed Subchronically to Microcystins From Toxic Cyanobacterial Blooms Under Laboratory Conditions." Toxicon : Official Journal of the International Society On Toxinology, vol. 46, no. 7, 2005, pp. 725-35.
Molina R, Moreno I, Pichardo S, et al. Acid and alkaline phosphatase activities and pathological changes induced in Tilapia fish (Oreochromis sp.) exposed subchronically to microcystins from toxic cyanobacterial blooms under laboratory conditions. Toxicon. 2005;46(7):725-35.
Molina, R., Moreno, I., Pichardo, S., Jos, A., Moyano, R., Monterde, J. G., & Cameán, A. (2005). Acid and alkaline phosphatase activities and pathological changes induced in Tilapia fish (Oreochromis sp.) exposed subchronically to microcystins from toxic cyanobacterial blooms under laboratory conditions. Toxicon : Official Journal of the International Society On Toxinology, 46(7), 725-35.
Molina R, et al. Acid and Alkaline Phosphatase Activities and Pathological Changes Induced in Tilapia Fish (Oreochromis Sp.) Exposed Subchronically to Microcystins From Toxic Cyanobacterial Blooms Under Laboratory Conditions. Toxicon. 2005 Dec 1;46(7):725-35. PubMed PMID: 16185737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acid and alkaline phosphatase activities and pathological changes induced in Tilapia fish (Oreochromis sp.) exposed subchronically to microcystins from toxic cyanobacterial blooms under laboratory conditions. AU - Molina,R, AU - Moreno,I, AU - Pichardo,S, AU - Jos,A, AU - Moyano,R, AU - Monterde,J G, AU - Cameán,A, Y1 - 2005/09/26/ PY - 2005/06/03/received PY - 2005/07/18/revised PY - 2005/07/20/accepted PY - 2005/9/28/pubmed PY - 2006/1/26/medline PY - 2005/9/28/entrez SP - 725 EP - 35 JF - Toxicon : official journal of the International Society on Toxinology JO - Toxicon VL - 46 IS - 7 N2 - The effects of microcystins (MCs) from cyanobacterial cells on the enzymatic activities of acid and alkaline phosphatases (ACP and ALP) from liver, kidney and gill tissues, and the histopathological changes in freshwater Tilapia fish (Oreochromis sp.) were investigated under laboratory conditions. Fish were exposed to cyanobacterial cells (60.0 microg MC-LR/fish per day) through their diet at different exposure times (14 and 21 days). The cells were fed to the fish in two types of oral administration: mixed with a commercial fish food or crushed into a commercial fish food so that the toxins were released. ACP and ALP activities changed in response to MCs in a time-dependent manner, and these changes were more prominent in liver and kidney. The way the MCs were administered had no influence on the biochemical parameters. Similarly, the most severe histopathological changes were observed in the same two organs, although the gills and intestines were also affected. The parenchymal architecture of the liver was dissolved, and round hepatocytes with the appearance of pyknotic nuclei were detected. Kidney lesions consisted of the dilation of Bowman's space and necrotic epithelial cells with pyknotic nuclei in the tubules. These findings suggest that low and repeated doses of MC-LR from cyanobacterial cells induce toxicity in tilapia fish although no adverse effects were detected. SN - 0041-0101 UR - https://www.unboundmedicine.com/medline/citation/16185737/Acid_and_alkaline_phosphatase_activities_and_pathological_changes_induced_in_Tilapia_fish__Oreochromis_sp___exposed_subchronically_to_microcystins_from_toxic_cyanobacterial_blooms_under_laboratory_conditions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-0101(05)00265-5 DB - PRIME DP - Unbound Medicine ER -