Tags

Type your tag names separated by a space and hit enter

Smoking and development of type 2 diabetes in patients with decreased functional capacity.
Int J Cardiol. 2005 Oct 10; 104(3):275-81.IJ

Abstract

OBJECTIVE

Data regarding the possible contribution of cigarette smoking to development of type 2 diabetes are scarce and inconclusive. Patients with impaired functional capacity and diminished physical activity are prone to develop new diabetes. However, the role of smoking on diabetes incidence among these patients has not been specifically investigated. The present study was aimed to evaluate the association between cigarette smoking and development of type 2 diabetes in patients with coronary artery disease and decreased functional capacity over a 6.2-year follow-up period.

METHODS

The study sample comprised 630 nondiabetic patients aged 45-74 years, with a fasting blood glucose of <126 mg/dl and with impaired functional capacity (New York Heart Association functional class II and III). The sample was classified into two groups: 1) non smokers (never and past smokers pooled together)--552 patients and 2) current smokers--78 patients.

RESULTS

Smokers were younger but they had a relatively unfavorable lipid profile (with respect to apolipoproteins A, triglyceride and HDL-cholesterol levels). No significant differences between the groups were found for weight, body mass index, total cholesterol and blood pressure. During the follow-up, development of new diabetes was recorded in 98 patients: in 80 (14.5%) non smokers and in 18 (23.1%) smokers, p=0.05. Among the non smokers, there were no significant differences in diabetes incidence between 357 past smokers and 195 never smokers: respectively, 48 (13.4%) and 32 (16.4%), p=0.34. In addition, all-cause mortality among the smokers (23.1%) was significantly higher than in non smokers (12.7%), p=0.01. Multivariate analysis identified current smoking as an independent predictor of increased risk of new diabetes development with a hazard ratio of 1.94 (95% confidence interval 1.16-3.25).

CONCLUSIONS

Current smoking was associated with an independent two-fold increased risk for development of type 2 diabetes in patients with impaired functional capacity.

Authors+Show Affiliations

Cardiac Rehabilitation Institute, Chaim Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. altenen@post.tau.ac.ilNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

16186056

Citation

Tenenbaum, Alexander, et al. "Smoking and Development of Type 2 Diabetes in Patients With Decreased Functional Capacity." International Journal of Cardiology, vol. 104, no. 3, 2005, pp. 275-81.
Tenenbaum A, Fisman EZ, Adler Y, et al. Smoking and development of type 2 diabetes in patients with decreased functional capacity. Int J Cardiol. 2005;104(3):275-81.
Tenenbaum, A., Fisman, E. Z., Adler, Y., Motro, M., Boyko, V., & Behar, S. (2005). Smoking and development of type 2 diabetes in patients with decreased functional capacity. International Journal of Cardiology, 104(3), 275-81.
Tenenbaum A, et al. Smoking and Development of Type 2 Diabetes in Patients With Decreased Functional Capacity. Int J Cardiol. 2005 Oct 10;104(3):275-81. PubMed PMID: 16186056.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Smoking and development of type 2 diabetes in patients with decreased functional capacity. AU - Tenenbaum,Alexander, AU - Fisman,Enrique Z, AU - Adler,Yehuda, AU - Motro,Michael, AU - Boyko,Valentina, AU - Behar,Solomon, PY - 2004/06/23/received PY - 2004/10/09/accepted PY - 2005/9/28/pubmed PY - 2006/3/1/medline PY - 2005/9/28/entrez SP - 275 EP - 81 JF - International journal of cardiology JO - Int J Cardiol VL - 104 IS - 3 N2 - OBJECTIVE: Data regarding the possible contribution of cigarette smoking to development of type 2 diabetes are scarce and inconclusive. Patients with impaired functional capacity and diminished physical activity are prone to develop new diabetes. However, the role of smoking on diabetes incidence among these patients has not been specifically investigated. The present study was aimed to evaluate the association between cigarette smoking and development of type 2 diabetes in patients with coronary artery disease and decreased functional capacity over a 6.2-year follow-up period. METHODS: The study sample comprised 630 nondiabetic patients aged 45-74 years, with a fasting blood glucose of <126 mg/dl and with impaired functional capacity (New York Heart Association functional class II and III). The sample was classified into two groups: 1) non smokers (never and past smokers pooled together)--552 patients and 2) current smokers--78 patients. RESULTS: Smokers were younger but they had a relatively unfavorable lipid profile (with respect to apolipoproteins A, triglyceride and HDL-cholesterol levels). No significant differences between the groups were found for weight, body mass index, total cholesterol and blood pressure. During the follow-up, development of new diabetes was recorded in 98 patients: in 80 (14.5%) non smokers and in 18 (23.1%) smokers, p=0.05. Among the non smokers, there were no significant differences in diabetes incidence between 357 past smokers and 195 never smokers: respectively, 48 (13.4%) and 32 (16.4%), p=0.34. In addition, all-cause mortality among the smokers (23.1%) was significantly higher than in non smokers (12.7%), p=0.01. Multivariate analysis identified current smoking as an independent predictor of increased risk of new diabetes development with a hazard ratio of 1.94 (95% confidence interval 1.16-3.25). CONCLUSIONS: Current smoking was associated with an independent two-fold increased risk for development of type 2 diabetes in patients with impaired functional capacity. SN - 0167-5273 UR - https://www.unboundmedicine.com/medline/citation/16186056/Smoking_and_development_of_type_2_diabetes_in_patients_with_decreased_functional_capacity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(05)00182-8 DB - PRIME DP - Unbound Medicine ER -