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Age, gender and metabolic syndrome-related coronary heart disease in U.S. adults.
Int J Cardiol 2005; 104(3):288-91IJ

Abstract

BACKGROUND

Metabolic syndrome (MetS), a clustering of several prominent risk factors for atherosclerosis, is common among U.S. populations. The contribution of MetS to the prevalence of coronary heart disease (CHD) in different age-gender groups is currently unknown.

METHODS

MetS was defined according to the definition of the National Cholesterol Education Program Adult Treatment Panel III. CHD was defined as having had a diagnosed heart attack in self-reported medical history. Data from the Third National Health and Nutrition Examination Survey (NHANES III) were used to evaluate the MetS-associated CHD prevalences in different age-gender subpopulations, which include 35- to 54-year-old women, 55- to 74-year-old women, 35- to 54-year-old men, and 55- to 74-year-old men.

RESULTS

The prevalences of MetS in these 4 age-gender subpopulations are 21%, 24%, 39%, and 38%, respectively. The odds ratios (and the 95% confidence intervals) of MetS to increased CHD in each subpopulations are 1.05 (0.40-2.79), 1.95 (1.19-3.20), 2.22 (1.03-4.81), and 1.96 (1.41-2.70), respectively.

CONCLUSIONS

MetS-associated CHD prevalence in women aged 35-54 years is almost the same as in the control, whereas in women aged 55-74 and in men aged 35-54 or 55-74, this prevalence is about 2-fold that of the control. Endogenous estrogen may play a role in suppressing the pro-atherosclerotic effects of MetS-related risk factors, but further studies are needed for a more certain conclusion.

Authors+Show Affiliations

Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, 600 N. Wolfe Street, Blalock 569, Baltimore, Maryland 21287-0409, United States.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16186058

Citation

Tong, Wenjing, et al. "Age, Gender and Metabolic Syndrome-related Coronary Heart Disease in U.S. Adults." International Journal of Cardiology, vol. 104, no. 3, 2005, pp. 288-91.
Tong W, Lai H, Yang C, et al. Age, gender and metabolic syndrome-related coronary heart disease in U.S. adults. Int J Cardiol. 2005;104(3):288-91.
Tong, W., Lai, H., Yang, C., Ren, S., Dai, S., & Lai, S. (2005). Age, gender and metabolic syndrome-related coronary heart disease in U.S. adults. International Journal of Cardiology, 104(3), pp. 288-91.
Tong W, et al. Age, Gender and Metabolic Syndrome-related Coronary Heart Disease in U.S. Adults. Int J Cardiol. 2005 Oct 10;104(3):288-91. PubMed PMID: 16186058.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age, gender and metabolic syndrome-related coronary heart disease in U.S. adults. AU - Tong,Wenjing, AU - Lai,Hong, AU - Yang,Chunyan, AU - Ren,Shiquan, AU - Dai,Shupeng, AU - Lai,Shenghan, PY - 2004/06/27/received PY - 2004/10/16/accepted PY - 2005/9/28/pubmed PY - 2006/3/1/medline PY - 2005/9/28/entrez SP - 288 EP - 91 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 104 IS - 3 N2 - BACKGROUND: Metabolic syndrome (MetS), a clustering of several prominent risk factors for atherosclerosis, is common among U.S. populations. The contribution of MetS to the prevalence of coronary heart disease (CHD) in different age-gender groups is currently unknown. METHODS: MetS was defined according to the definition of the National Cholesterol Education Program Adult Treatment Panel III. CHD was defined as having had a diagnosed heart attack in self-reported medical history. Data from the Third National Health and Nutrition Examination Survey (NHANES III) were used to evaluate the MetS-associated CHD prevalences in different age-gender subpopulations, which include 35- to 54-year-old women, 55- to 74-year-old women, 35- to 54-year-old men, and 55- to 74-year-old men. RESULTS: The prevalences of MetS in these 4 age-gender subpopulations are 21%, 24%, 39%, and 38%, respectively. The odds ratios (and the 95% confidence intervals) of MetS to increased CHD in each subpopulations are 1.05 (0.40-2.79), 1.95 (1.19-3.20), 2.22 (1.03-4.81), and 1.96 (1.41-2.70), respectively. CONCLUSIONS: MetS-associated CHD prevalence in women aged 35-54 years is almost the same as in the control, whereas in women aged 55-74 and in men aged 35-54 or 55-74, this prevalence is about 2-fold that of the control. Endogenous estrogen may play a role in suppressing the pro-atherosclerotic effects of MetS-related risk factors, but further studies are needed for a more certain conclusion. SN - 0167-5273 UR - https://www.unboundmedicine.com/medline/citation/16186058/Age_gender_and_metabolic_syndrome_related_coronary_heart_disease_in_U_S__adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(05)00184-1 DB - PRIME DP - Unbound Medicine ER -