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Change in body mass index and risk of incident Alzheimer disease.
Neurology 2005; 65(6):892-7Neur

Abstract

OBJECTIVE

To examine the association of change in body mass index (BMI) with risk of Alzheimer disease (AD).

METHODS

Nine hundred eighteen older Catholic clergy participating in the Religious Orders Study without dementia at baseline were studied. Outcome measures were the clinical diagnosis of AD and change in cognitive function.

RESULTS

During a mean follow-up of 5.5 years, 151 persons developed AD. BMI averaged 27.4 at baseline and declined in about half the participants. In a proportional hazards model adjusted for age, sex, and education, each 1-unit less of BMI at baseline was associated with about a 5% increase in the risk of AD (hazard ratio = 0.944; 95% CI = 0.908 to 0.981), and each 1-unit annual decline in BMI (about the 10th percentile) was associated with about a 35% increase in the risk of AD compared with a person experiencing no change in BMI (about the 50th percentile) (hazard ratio = 0.730; 95% CI = 0.625 to 0.852). The results were similar after controlling for chronic diseases and excluding persons who developed AD during the first 4 years of observation. Random effects models showed that the rate of cognitive decline increased by about 8% for each 1-unit less of BMI at baseline and declined an additional 40%/year in persons losing 1 unit of BMI/year compared with those with no change in BMI.

CONCLUSION

Declining body mass index (BMI) is associated with increased risk of incident Alzheimer disease (AD). Loss of BMI may reflect pathologic processes that contribute to the subsequent development of AD.

Authors+Show Affiliations

Rush Alzheimer's Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA. Aron_S_Buchman@rush.edu

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16186530

Citation

Buchman, A S., et al. "Change in Body Mass Index and Risk of Incident Alzheimer Disease." Neurology, vol. 65, no. 6, 2005, pp. 892-7.
Buchman AS, Wilson RS, Bienias JL, et al. Change in body mass index and risk of incident Alzheimer disease. Neurology. 2005;65(6):892-7.
Buchman, A. S., Wilson, R. S., Bienias, J. L., Shah, R. C., Evans, D. A., & Bennett, D. A. (2005). Change in body mass index and risk of incident Alzheimer disease. Neurology, 65(6), pp. 892-7.
Buchman AS, et al. Change in Body Mass Index and Risk of Incident Alzheimer Disease. Neurology. 2005 Sep 27;65(6):892-7. PubMed PMID: 16186530.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Change in body mass index and risk of incident Alzheimer disease. AU - Buchman,A S, AU - Wilson,R S, AU - Bienias,J L, AU - Shah,R C, AU - Evans,D A, AU - Bennett,D A, PY - 2005/9/28/pubmed PY - 2006/3/11/medline PY - 2005/9/28/entrez SP - 892 EP - 7 JF - Neurology JO - Neurology VL - 65 IS - 6 N2 - OBJECTIVE: To examine the association of change in body mass index (BMI) with risk of Alzheimer disease (AD). METHODS: Nine hundred eighteen older Catholic clergy participating in the Religious Orders Study without dementia at baseline were studied. Outcome measures were the clinical diagnosis of AD and change in cognitive function. RESULTS: During a mean follow-up of 5.5 years, 151 persons developed AD. BMI averaged 27.4 at baseline and declined in about half the participants. In a proportional hazards model adjusted for age, sex, and education, each 1-unit less of BMI at baseline was associated with about a 5% increase in the risk of AD (hazard ratio = 0.944; 95% CI = 0.908 to 0.981), and each 1-unit annual decline in BMI (about the 10th percentile) was associated with about a 35% increase in the risk of AD compared with a person experiencing no change in BMI (about the 50th percentile) (hazard ratio = 0.730; 95% CI = 0.625 to 0.852). The results were similar after controlling for chronic diseases and excluding persons who developed AD during the first 4 years of observation. Random effects models showed that the rate of cognitive decline increased by about 8% for each 1-unit less of BMI at baseline and declined an additional 40%/year in persons losing 1 unit of BMI/year compared with those with no change in BMI. CONCLUSION: Declining body mass index (BMI) is associated with increased risk of incident Alzheimer disease (AD). Loss of BMI may reflect pathologic processes that contribute to the subsequent development of AD. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/16186530/Change_in_body_mass_index_and_risk_of_incident_Alzheimer_disease_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=16186530 DB - PRIME DP - Unbound Medicine ER -