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Education modifies the association of amyloid but not tangles with cognitive function.

Abstract

The authors quantified amyloid and tau tangles in Religious Orders Study participants. In separate analyses, amyloid and tangles were related to level of cognition. When terms for education's interaction with amyloid and tangles were added, education dampened the association of amyloid with level of cognition (p = 0.02) but not the association of neurofibrillary tangles with level of cognition, suggesting that education is related to factors that reduce the effect of amyloid on cognition.

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  • Authors+Show Affiliations

    ,

    Rush Alzheimer's Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA. dbennett@rush.edu

    , , ,

    Source

    Neurology 65:6 2005 Sep 27 pg 953-5

    MeSH

    Activities of Daily Living
    Age of Onset
    Aged
    Aged, 80 and over
    Alzheimer Disease
    Cerebral Cortex
    Cognition
    Cognition Disorders
    Disease Progression
    Educational Status
    Female
    Humans
    Life Style
    Male
    Nerve Tissue Proteins
    Neural Pathways
    Neurofibrillary Tangles
    Neurons
    Plaque, Amyloid
    tau Proteins

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    16186546

    Citation

    Bennett, D A., et al. "Education Modifies the Association of Amyloid but Not Tangles With Cognitive Function." Neurology, vol. 65, no. 6, 2005, pp. 953-5.
    Bennett DA, Schneider JA, Wilson RS, et al. Education modifies the association of amyloid but not tangles with cognitive function. Neurology. 2005;65(6):953-5.
    Bennett, D. A., Schneider, J. A., Wilson, R. S., Bienias, J. L., & Arnold, S. E. (2005). Education modifies the association of amyloid but not tangles with cognitive function. Neurology, 65(6), pp. 953-5.
    Bennett DA, et al. Education Modifies the Association of Amyloid but Not Tangles With Cognitive Function. Neurology. 2005 Sep 27;65(6):953-5. PubMed PMID: 16186546.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Education modifies the association of amyloid but not tangles with cognitive function. AU - Bennett,D A, AU - Schneider,J A, AU - Wilson,R S, AU - Bienias,J L, AU - Arnold,S E, PY - 2005/9/28/pubmed PY - 2006/3/11/medline PY - 2005/9/28/entrez SP - 953 EP - 5 JF - Neurology JO - Neurology VL - 65 IS - 6 N2 - The authors quantified amyloid and tau tangles in Religious Orders Study participants. In separate analyses, amyloid and tangles were related to level of cognition. When terms for education's interaction with amyloid and tangles were added, education dampened the association of amyloid with level of cognition (p = 0.02) but not the association of neurofibrillary tangles with level of cognition, suggesting that education is related to factors that reduce the effect of amyloid on cognition. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/16186546/Education_modifies_the_association_of_amyloid_but_not_tangles_with_cognitive_function_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=16186546 DB - PRIME DP - Unbound Medicine ER -