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[Effect of vitamin E supplementation on the vitamin content of lipoprotein in young men and women].
Orv Hetil. 2005 Aug 28; 146(35):1813-8.OH

Abstract

The effect of supplementary Vitamin E on the vitamin content of lipoproteins in young men and women. Inappropriate vitamin and trace element supplementation may facilitate the development of atherosclerosis. It is known that Vitamin E protects lipids from oxidative stress, while clinical signs of atherosclerosis appear later in women compared to men.

AIMS

(1) The increase of vitamin E in plasma and plasma lipoproteins after 4 weeks of supplementation vitamin E was investigated, (2) furthermore it was tested whether a proportion shift occurs in alpha-tocopherol content of lipoproteins, (3) and checked for gender-related differences in plasma and plasma lipoprotein vitamin E levels before, during and after treatment, (4) plasma CRP levels as a marker of lipid peroxidation were also followed.

METHODS

5-5 young healthy men and women took part in the study, receiving 700 IU/day Vitamin E for one month. Each subject was studied before and at the end of treatment, and also one month after treatment. HDL and LDL-VLDL containing lipoproteins were separated. Vitamin E and hsCRP levels were measured (by HPLC and an immunoturbidimetric method, respectively).

RESULTS

Vitamin E treatment induced in both genders an approximately threefold increase in vitamin E concentration in HDL-cholesterol (8.1 +/- 1.7 micromol/l vs. 22.5 +/- 7.5 micromol/l, p < 0.001), and a twofold increase in LDL-VLDL-cholesterol (22.0 +/- 3.7 micromol/l vs. 49.0 +/- 9.0 micromol/l, p < 0.001). Plasma and HDL vitamin E levels were higher in women than in men at the onset of treatment (6.8 +/- 0.96 micromol/l vs. 9.5 +/- 1.10 micromol/l), but during the treatment these gender-related differences disappeared. When plasma vitamin E concentration were considered 100% and the changes of the vitamin E concentrations of lipoproteins were calculated, it was found that supplementation with vitamin E in men increased the vitamin E concentration of LDL-VLDL cholesterol to a higher extent compared to women (LDL-VLDL % in men: 59.8 +/- 7.43%, in women: 49.3 +/- 7.41%, p < 0.05). All the observed changes regressed one month after cessation of supplementation. The level of hsCRP decreased during vitamin E treatment (1.07 +/- 0.9 mg/l vs. 0.2 +/- 0.14 mg/l, p < 0.001), and remained suppressed after the cessation of treatment (0.37 +/- 0.4, p < 0.01).

CONCLUSIONS

These results support the hypothesis that women at young age are better protected against lipid-peroxidation as compared to men because of higher HDL vitamin E concentrations. Vitamin E supplementation in men eliminates this concentration difference between genders, and also increases LDL-VLDL vitamin E. In both genders high concentration of vitamin E in lipoproteins was associated with low hsCRP concentration.

Authors+Show Affiliations

Semmelweis Egyetem, Altalános Orvostudományi Kar, Budapest, II. Belgyógyászati Klinika, Budapest.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
English Abstract
Journal Article

Language

hun

PubMed ID

16187540

Citation

Somogyi, Anikó, et al. "[Effect of Vitamin E Supplementation On the Vitamin Content of Lipoprotein in Young Men and Women]." Orvosi Hetilap, vol. 146, no. 35, 2005, pp. 1813-8.
Somogyi A, Herold M, Kocsis I, et al. [Effect of vitamin E supplementation on the vitamin content of lipoprotein in young men and women]. Orv Hetil. 2005;146(35):1813-8.
Somogyi, A., Herold, M., Kocsis, I., Nagy, G., Somfai, G., & Studinger, P. (2005). [Effect of vitamin E supplementation on the vitamin content of lipoprotein in young men and women]. Orvosi Hetilap, 146(35), 1813-8.
Somogyi A, et al. [Effect of Vitamin E Supplementation On the Vitamin Content of Lipoprotein in Young Men and Women]. Orv Hetil. 2005 Aug 28;146(35):1813-8. PubMed PMID: 16187540.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of vitamin E supplementation on the vitamin content of lipoprotein in young men and women]. AU - Somogyi,Anikó, AU - Herold,Magdolna, AU - Kocsis,Ibolya, AU - Nagy,Géza, AU - Somfai,Gábor, AU - Studinger,Péter, PY - 2005/9/29/pubmed PY - 2005/12/13/medline PY - 2005/9/29/entrez SP - 1813 EP - 8 JF - Orvosi hetilap JO - Orv Hetil VL - 146 IS - 35 N2 - UNLABELLED: The effect of supplementary Vitamin E on the vitamin content of lipoproteins in young men and women. Inappropriate vitamin and trace element supplementation may facilitate the development of atherosclerosis. It is known that Vitamin E protects lipids from oxidative stress, while clinical signs of atherosclerosis appear later in women compared to men. AIMS: (1) The increase of vitamin E in plasma and plasma lipoproteins after 4 weeks of supplementation vitamin E was investigated, (2) furthermore it was tested whether a proportion shift occurs in alpha-tocopherol content of lipoproteins, (3) and checked for gender-related differences in plasma and plasma lipoprotein vitamin E levels before, during and after treatment, (4) plasma CRP levels as a marker of lipid peroxidation were also followed. METHODS: 5-5 young healthy men and women took part in the study, receiving 700 IU/day Vitamin E for one month. Each subject was studied before and at the end of treatment, and also one month after treatment. HDL and LDL-VLDL containing lipoproteins were separated. Vitamin E and hsCRP levels were measured (by HPLC and an immunoturbidimetric method, respectively). RESULTS: Vitamin E treatment induced in both genders an approximately threefold increase in vitamin E concentration in HDL-cholesterol (8.1 +/- 1.7 micromol/l vs. 22.5 +/- 7.5 micromol/l, p < 0.001), and a twofold increase in LDL-VLDL-cholesterol (22.0 +/- 3.7 micromol/l vs. 49.0 +/- 9.0 micromol/l, p < 0.001). Plasma and HDL vitamin E levels were higher in women than in men at the onset of treatment (6.8 +/- 0.96 micromol/l vs. 9.5 +/- 1.10 micromol/l), but during the treatment these gender-related differences disappeared. When plasma vitamin E concentration were considered 100% and the changes of the vitamin E concentrations of lipoproteins were calculated, it was found that supplementation with vitamin E in men increased the vitamin E concentration of LDL-VLDL cholesterol to a higher extent compared to women (LDL-VLDL % in men: 59.8 +/- 7.43%, in women: 49.3 +/- 7.41%, p < 0.05). All the observed changes regressed one month after cessation of supplementation. The level of hsCRP decreased during vitamin E treatment (1.07 +/- 0.9 mg/l vs. 0.2 +/- 0.14 mg/l, p < 0.001), and remained suppressed after the cessation of treatment (0.37 +/- 0.4, p < 0.01). CONCLUSIONS: These results support the hypothesis that women at young age are better protected against lipid-peroxidation as compared to men because of higher HDL vitamin E concentrations. Vitamin E supplementation in men eliminates this concentration difference between genders, and also increases LDL-VLDL vitamin E. In both genders high concentration of vitamin E in lipoproteins was associated with low hsCRP concentration. SN - 0030-6002 UR - https://www.unboundmedicine.com/medline/citation/16187540/[Effect_of_vitamin_E_supplementation_on_the_vitamin_content_of_lipoprotein_in_young_men_and_women]_ L2 - https://medlineplus.gov/vitamine.html DB - PRIME DP - Unbound Medicine ER -