Tags

Type your tag names separated by a space and hit enter

[Molecular mechanisms of action and health benefits of polyunsaturated fatty acids].
Rev Invest Clin. 2005 May-Jun; 57(3):457-72.RI

Abstract

Essential polyunsaturated fatty acids (PUFAs), linoleic acid n6 (LA) and linolenic acid (ALA) n3 obtained from the diet are precursors of the long-chain polyunsaturated fatty acids (Lc-PUFAs) arachidonic acid (AA) and docosahexaenoic acid (DHA) respectively. Consumption of PUFAs is related with a better neurological and cognitive development in newborns. It has been demonstrated that consumption of n-6 and n-3 PUFAs decreases blood triglycerides by increasing fatty acid oxidation through activation of PPARalpha or by reducing the activation of SREBP-1 inhibiting lipogenesis. Dietary PUFAs activate PPARalpha and PPARgamma increasing lipid oxidation, and decreasing insulin resistance leading in a reduction of hepatic steatosis. Beneficial effects of PUFAs have been observed in humans and in animals models of diabetes, obesity, cancer, and cardiovascular diseases. It is important to promote the consumption of PUFAs. Main food sources of PUFAs n-6 are corn, soy and safflower oil, and for PUFAs n-3 are fish, soy, canola oil and, flaxseed. Finally FAO/WHO recommends an optimal daily intake of n6/n3 of 5-10:1.

Authors+Show Affiliations

Uniddad de Investigación Médica en Nutrición, Centro Médico Nacional Siglo XXI, IMSS.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

spa

PubMed ID

16187707

Citation

Rodríguez-Cruz, Maricela, et al. "[Molecular Mechanisms of Action and Health Benefits of Polyunsaturated Fatty Acids]." Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion, vol. 57, no. 3, 2005, pp. 457-72.
Rodríguez-Cruz M, Tovar AR, del Prado M, et al. [Molecular mechanisms of action and health benefits of polyunsaturated fatty acids]. Rev Invest Clin. 2005;57(3):457-72.
Rodríguez-Cruz, M., Tovar, A. R., del Prado, M., & Torres, N. (2005). [Molecular mechanisms of action and health benefits of polyunsaturated fatty acids]. Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion, 57(3), 457-72.
Rodríguez-Cruz M, et al. [Molecular Mechanisms of Action and Health Benefits of Polyunsaturated Fatty Acids]. Rev Invest Clin. 2005 May-Jun;57(3):457-72. PubMed PMID: 16187707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Molecular mechanisms of action and health benefits of polyunsaturated fatty acids]. AU - Rodríguez-Cruz,Maricela, AU - Tovar,Armando R, AU - del Prado,Martha, AU - Torres,Nimbe, PY - 2005/9/29/pubmed PY - 2005/10/27/medline PY - 2005/9/29/entrez SP - 457 EP - 72 JF - Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion JO - Rev Invest Clin VL - 57 IS - 3 N2 - Essential polyunsaturated fatty acids (PUFAs), linoleic acid n6 (LA) and linolenic acid (ALA) n3 obtained from the diet are precursors of the long-chain polyunsaturated fatty acids (Lc-PUFAs) arachidonic acid (AA) and docosahexaenoic acid (DHA) respectively. Consumption of PUFAs is related with a better neurological and cognitive development in newborns. It has been demonstrated that consumption of n-6 and n-3 PUFAs decreases blood triglycerides by increasing fatty acid oxidation through activation of PPARalpha or by reducing the activation of SREBP-1 inhibiting lipogenesis. Dietary PUFAs activate PPARalpha and PPARgamma increasing lipid oxidation, and decreasing insulin resistance leading in a reduction of hepatic steatosis. Beneficial effects of PUFAs have been observed in humans and in animals models of diabetes, obesity, cancer, and cardiovascular diseases. It is important to promote the consumption of PUFAs. Main food sources of PUFAs n-6 are corn, soy and safflower oil, and for PUFAs n-3 are fish, soy, canola oil and, flaxseed. Finally FAO/WHO recommends an optimal daily intake of n6/n3 of 5-10:1. SN - 0034-8376 UR - https://www.unboundmedicine.com/medline/citation/16187707/[Molecular_mechanisms_of_action_and_health_benefits_of_polyunsaturated_fatty_acids]_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:16187707 DB - PRIME DP - Unbound Medicine ER -