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Ondansetron and Delta-9-tetrahydrocannabinol interfere with the establishment of lithium-induced conditioned taste avoidance in the house musk shrew (Suncus murinus).
Behav Neurosci 2005; 119(4):974-82BN

Abstract

Considerable evidence suggests that rats can learn to avoid a taste in the absence of nausea. The current experiments evaluated the potential of the antiemetic agents, ondansetron (OND) and delta-9-tetrahydrocannabinol (THC), to interfere with lithium chloride (LiCl)-induced taste avoidance in the house musk shrew, Suncus murinus, an insectivore that, unlike rats, is capable of vomiting. At a dose that did not modify saccharin (Experiment 1) or sucrose (Experiment 2) intake, OND prevented the establishment of LiCl-induced taste avoidance in the shrew. A low dose of THC (1 mg/kg), which did not modify sucrose intake during conditioning, also prevented the establishment of LiCl-induced taste avoidance in the shrew. Higher doses of THC were also effective, but they also suppressed sucrose consumption during conditioning. These results suggest that nausea is a necessary component of the unconditioned stimulus for the establishment of conditioned taste avoidance in the shrew, unlike the rat, which does not vomit when injected with a toxin.

Authors+Show Affiliations

Department of Psychology, Wilfrid Laurier University, Waterloo, ON, Canada.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16187826

Citation

Kwiatkowska, Magdalena, and Linda A. Parker. "Ondansetron and Delta-9-tetrahydrocannabinol Interfere With the Establishment of Lithium-induced Conditioned Taste Avoidance in the House Musk Shrew (Suncus Murinus)." Behavioral Neuroscience, vol. 119, no. 4, 2005, pp. 974-82.
Kwiatkowska M, Parker LA. Ondansetron and Delta-9-tetrahydrocannabinol interfere with the establishment of lithium-induced conditioned taste avoidance in the house musk shrew (Suncus murinus). Behav Neurosci. 2005;119(4):974-82.
Kwiatkowska, M., & Parker, L. A. (2005). Ondansetron and Delta-9-tetrahydrocannabinol interfere with the establishment of lithium-induced conditioned taste avoidance in the house musk shrew (Suncus murinus). Behavioral Neuroscience, 119(4), pp. 974-82.
Kwiatkowska M, Parker LA. Ondansetron and Delta-9-tetrahydrocannabinol Interfere With the Establishment of Lithium-induced Conditioned Taste Avoidance in the House Musk Shrew (Suncus Murinus). Behav Neurosci. 2005;119(4):974-82. PubMed PMID: 16187826.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ondansetron and Delta-9-tetrahydrocannabinol interfere with the establishment of lithium-induced conditioned taste avoidance in the house musk shrew (Suncus murinus). AU - Kwiatkowska,Magdalena, AU - Parker,Linda A, PY - 2005/9/29/pubmed PY - 2006/1/24/medline PY - 2005/9/29/entrez SP - 974 EP - 82 JF - Behavioral neuroscience JO - Behav. Neurosci. VL - 119 IS - 4 N2 - Considerable evidence suggests that rats can learn to avoid a taste in the absence of nausea. The current experiments evaluated the potential of the antiemetic agents, ondansetron (OND) and delta-9-tetrahydrocannabinol (THC), to interfere with lithium chloride (LiCl)-induced taste avoidance in the house musk shrew, Suncus murinus, an insectivore that, unlike rats, is capable of vomiting. At a dose that did not modify saccharin (Experiment 1) or sucrose (Experiment 2) intake, OND prevented the establishment of LiCl-induced taste avoidance in the shrew. A low dose of THC (1 mg/kg), which did not modify sucrose intake during conditioning, also prevented the establishment of LiCl-induced taste avoidance in the shrew. Higher doses of THC were also effective, but they also suppressed sucrose consumption during conditioning. These results suggest that nausea is a necessary component of the unconditioned stimulus for the establishment of conditioned taste avoidance in the shrew, unlike the rat, which does not vomit when injected with a toxin. SN - 0735-7044 UR - https://www.unboundmedicine.com/medline/citation/16187826/Ondansetron_and_Delta_9_tetrahydrocannabinol_interfere_with_the_establishment_of_lithium_induced_conditioned_taste_avoidance_in_the_house_musk_shrew__Suncus_murinus__ DB - PRIME DP - Unbound Medicine ER -