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Maternal fish oil supplementation in lactation: effect on developmental outcome in breast-fed infants.
Reprod Nutr Dev. 2005 Sep-Oct; 45(5):535-47.RN

Abstract

Docosahexaenoic acid (DHA) accumulates in the brain during the 1st and 2nd years of life. The objective of this study was to see if an increased content of DHA in breast-milk via maternal fish oil (FO)-supplementation affects mental development in term infants. one hundred twenty-two Danish mothers with a habitual fish intake below the population median were randomized to 4.5 g.d(-1) of FO or olive oil (OO) for the first four months of lactation. Fifty-three mothers with habitual fish intake in the highest quartile were included as reference group. The effect of the resulting increase in infant DHA-intake and RBC-DHA level was assessed on problem solving ability at nine months and language at one and two years of age. Infants in the three groups performed equally well on the problem test and no association was observed between problem solving and erythrocyte-DHA at four months. Passive vocabulary at one year was lower in the children of the FO- compared with the OO-group (P < 0.05), but no differences were found at two years of age. Word comprehension at one year was inversely associated with erythrocyte-DHA at four months. The trial indicate a small effect of DHA levels in breast-milk on early language development of breast-fed infants.

Authors+Show Affiliations

Center for Advanced Food Studies, Department of Human Nutrition, The Royal Veterinary and Agricultural University, Rolighedsvej 30, 1958 Frederiksberg C, Denmark. ll@kvl.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16188206

Citation

Lauritzen, Lotte, et al. "Maternal Fish Oil Supplementation in Lactation: Effect On Developmental Outcome in Breast-fed Infants." Reproduction, Nutrition, Development, vol. 45, no. 5, 2005, pp. 535-47.
Lauritzen L, Jørgensen MH, Olsen SF, et al. Maternal fish oil supplementation in lactation: effect on developmental outcome in breast-fed infants. Reprod Nutr Dev. 2005;45(5):535-47.
Lauritzen, L., Jørgensen, M. H., Olsen, S. F., Straarup, E. M., & Michaelsen, K. F. (2005). Maternal fish oil supplementation in lactation: effect on developmental outcome in breast-fed infants. Reproduction, Nutrition, Development, 45(5), 535-47.
Lauritzen L, et al. Maternal Fish Oil Supplementation in Lactation: Effect On Developmental Outcome in Breast-fed Infants. Reprod Nutr Dev. 2005 Sep-Oct;45(5):535-47. PubMed PMID: 16188206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal fish oil supplementation in lactation: effect on developmental outcome in breast-fed infants. AU - Lauritzen,Lotte, AU - Jørgensen,Marianne H, AU - Olsen,Sjúrdur F, AU - Straarup,Ellen Marie, AU - Michaelsen,Kim F, PY - 2005/9/29/pubmed PY - 2005/12/13/medline PY - 2005/9/29/entrez SP - 535 EP - 47 JF - Reproduction, nutrition, development JO - Reprod Nutr Dev VL - 45 IS - 5 N2 - Docosahexaenoic acid (DHA) accumulates in the brain during the 1st and 2nd years of life. The objective of this study was to see if an increased content of DHA in breast-milk via maternal fish oil (FO)-supplementation affects mental development in term infants. one hundred twenty-two Danish mothers with a habitual fish intake below the population median were randomized to 4.5 g.d(-1) of FO or olive oil (OO) for the first four months of lactation. Fifty-three mothers with habitual fish intake in the highest quartile were included as reference group. The effect of the resulting increase in infant DHA-intake and RBC-DHA level was assessed on problem solving ability at nine months and language at one and two years of age. Infants in the three groups performed equally well on the problem test and no association was observed between problem solving and erythrocyte-DHA at four months. Passive vocabulary at one year was lower in the children of the FO- compared with the OO-group (P < 0.05), but no differences were found at two years of age. Word comprehension at one year was inversely associated with erythrocyte-DHA at four months. The trial indicate a small effect of DHA levels in breast-milk on early language development of breast-fed infants. SN - 0926-5287 UR - https://www.unboundmedicine.com/medline/citation/16188206/Maternal_fish_oil_supplementation_in_lactation:_effect_on_developmental_outcome_in_breast_fed_infants_ L2 - http://publications.edpsciences.org/10.1051/rnd:2005044 DB - PRIME DP - Unbound Medicine ER -