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In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography.
J Clin Endocrinol Metab 2005; 90(12):6508-15JC

Abstract

CONTEXT

Assessment of trabecular microarchitecture may enhance the prediction of fracture risk and improve monitoring of treatment response. A new high-resolution peripheral quantitative computed tomography (HR-pQCT) system permits in vivo assessment of trabecular architecture and volumetric bone mineral density (BMD) at the distal radius and tibia with a voxel size of 82 microm3.

OBJECTIVE AND PATIENTS

We determined the short-term reproducibility of this device by measuring 15 healthy volunteers three times each. We compared HR-pQCT measurements in 108 healthy premenopausal, 113 postmenopausal osteopenic, and 35 postmenopausal osteoporotic women. Furthermore, we compared values in postmenopausal osteopenic women with (n = 35) and without previous fracture history (n = 78).

DESIGN AND SETTING

We conducted a cross-sectional study in a private clinical research center.

INTERVENTION AND MAIN OUTCOME MEASURE

We took HR-pQCT measurements of the radius and tibia. Femoral neck and spine BMD were measured in postmenopausal women by dual-energy x-ray absorptiometry.

RESULTS

Precision of HR-pQCT measurements was 0.7-1.5% for total, trabecular, and cortical densities and 2.5-4.4% for trabecular architecture. Postmenopausal women had lower density, trabecular number, and cortical thickness than premenopausal women (P < 0.001) at both radius and tibia. Osteoporotic women had lower density, cortical thickness, and increased trabecular separation than osteopenic women (P < 0.01) at both sites. Furthermore, although spine and hip BMD were similar, fractured osteopenic women had lower trabecular density and more heterogeneous trabecular distribution (P < 0.02) at the radius compared with unfractured osteopenic women.

CONCLUSION

HR-pQCT appears promising to assess bone density and microarchitecture at peripheral sites in terms of reproducibility and ability to detect age- and disease-related changes.

Authors+Show Affiliations

INSERM Unit 403, and Claude Bernard University of Lyon, France.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Studies
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16189253

Citation

Boutroy, Stephanie, et al. "In Vivo Assessment of Trabecular Bone Microarchitecture By High-resolution Peripheral Quantitative Computed Tomography." The Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 12, 2005, pp. 6508-15.
Boutroy S, Bouxsein ML, Munoz F, et al. In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography. J Clin Endocrinol Metab. 2005;90(12):6508-15.
Boutroy, S., Bouxsein, M. L., Munoz, F., & Delmas, P. D. (2005). In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography. The Journal of Clinical Endocrinology and Metabolism, 90(12), pp. 6508-15.
Boutroy S, et al. In Vivo Assessment of Trabecular Bone Microarchitecture By High-resolution Peripheral Quantitative Computed Tomography. J Clin Endocrinol Metab. 2005;90(12):6508-15. PubMed PMID: 16189253.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography. AU - Boutroy,Stephanie, AU - Bouxsein,Mary L, AU - Munoz,Francoise, AU - Delmas,Pierre D, Y1 - 2005/09/27/ PY - 2005/9/29/pubmed PY - 2006/1/13/medline PY - 2005/9/29/entrez SP - 6508 EP - 15 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 90 IS - 12 N2 - CONTEXT: Assessment of trabecular microarchitecture may enhance the prediction of fracture risk and improve monitoring of treatment response. A new high-resolution peripheral quantitative computed tomography (HR-pQCT) system permits in vivo assessment of trabecular architecture and volumetric bone mineral density (BMD) at the distal radius and tibia with a voxel size of 82 microm3. OBJECTIVE AND PATIENTS: We determined the short-term reproducibility of this device by measuring 15 healthy volunteers three times each. We compared HR-pQCT measurements in 108 healthy premenopausal, 113 postmenopausal osteopenic, and 35 postmenopausal osteoporotic women. Furthermore, we compared values in postmenopausal osteopenic women with (n = 35) and without previous fracture history (n = 78). DESIGN AND SETTING: We conducted a cross-sectional study in a private clinical research center. INTERVENTION AND MAIN OUTCOME MEASURE: We took HR-pQCT measurements of the radius and tibia. Femoral neck and spine BMD were measured in postmenopausal women by dual-energy x-ray absorptiometry. RESULTS: Precision of HR-pQCT measurements was 0.7-1.5% for total, trabecular, and cortical densities and 2.5-4.4% for trabecular architecture. Postmenopausal women had lower density, trabecular number, and cortical thickness than premenopausal women (P < 0.001) at both radius and tibia. Osteoporotic women had lower density, cortical thickness, and increased trabecular separation than osteopenic women (P < 0.01) at both sites. Furthermore, although spine and hip BMD were similar, fractured osteopenic women had lower trabecular density and more heterogeneous trabecular distribution (P < 0.02) at the radius compared with unfractured osteopenic women. CONCLUSION: HR-pQCT appears promising to assess bone density and microarchitecture at peripheral sites in terms of reproducibility and ability to detect age- and disease-related changes. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/16189253/In_vivo_assessment_of_trabecular_bone_microarchitecture_by_high_resolution_peripheral_quantitative_computed_tomography_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2005-1258 DB - PRIME DP - Unbound Medicine ER -