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Vitamin E supplementation in cardiovascular disease and cancer prevention: Part 1.
Ann Pharmacother 2005; 39(11):1870-8AP

Abstract

OBJECTIVE

To review clinical trials evaluating the safety and efficacy of vitamin E supplementation in cardiovascular disease and cancer prevention.

DATA SOURCES

Using the MeSH search terms alpha-tocopherol, tocopherols, vitamin E, cardiovascular diseases, cancer, malignancy, and clinical trials, a literature review was conducted to identify peer-reviewed articles in MEDLINE (1966-July 2005).

STUDY SELECTION AND DATA EXTRACTION

Published materials including original research, and previous meta-analyses were included. Only English-language articles and trials on vitamin E alone or in combination with other vitamins or minerals were reviewed. Emphasis was placed on prospective, randomized, double-blind, placebo-controlled clinical trials.

DATA SYNTHESIS

Eight clinical studies demonstrated contradicting results regarding the benefits of vitamin E in the prevention of cardiovascular disease and cancer. There is enough evidence from large, well-designed studies to discourage the use of vitamin E in the primary prevention of cardiovascular disease. Secondary prevention requires more adequate clinical trials with selected populations to examine protective effects of vitamin E in cardiovascular disease. The findings of the studies reviewed do not provide evidence that vitamin E may reduce the risk of cancer; thus, at the present time, we do not recommend daily vitamin E intake for cancer prevention is not recommended.

CONCLUSIONS

Available data do not support the supplementation of vitamin E in cardiovascular disease and cancer prevention.

Authors+Show Affiliations

Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201-5497, USA. david.pham@liu.eduNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

16189282

Citation

Pham, David Q., and Roda Plakogiannis. "Vitamin E Supplementation in Cardiovascular Disease and Cancer Prevention: Part 1." The Annals of Pharmacotherapy, vol. 39, no. 11, 2005, pp. 1870-8.
Pham DQ, Plakogiannis R. Vitamin E supplementation in cardiovascular disease and cancer prevention: Part 1. Ann Pharmacother. 2005;39(11):1870-8.
Pham, D. Q., & Plakogiannis, R. (2005). Vitamin E supplementation in cardiovascular disease and cancer prevention: Part 1. The Annals of Pharmacotherapy, 39(11), pp. 1870-8.
Pham DQ, Plakogiannis R. Vitamin E Supplementation in Cardiovascular Disease and Cancer Prevention: Part 1. Ann Pharmacother. 2005;39(11):1870-8. PubMed PMID: 16189282.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin E supplementation in cardiovascular disease and cancer prevention: Part 1. AU - Pham,David Q, AU - Plakogiannis,Roda, Y1 - 2005/09/27/ PY - 2005/9/29/pubmed PY - 2006/2/16/medline PY - 2005/9/29/entrez SP - 1870 EP - 8 JF - The Annals of pharmacotherapy JO - Ann Pharmacother VL - 39 IS - 11 N2 - OBJECTIVE: To review clinical trials evaluating the safety and efficacy of vitamin E supplementation in cardiovascular disease and cancer prevention. DATA SOURCES: Using the MeSH search terms alpha-tocopherol, tocopherols, vitamin E, cardiovascular diseases, cancer, malignancy, and clinical trials, a literature review was conducted to identify peer-reviewed articles in MEDLINE (1966-July 2005). STUDY SELECTION AND DATA EXTRACTION: Published materials including original research, and previous meta-analyses were included. Only English-language articles and trials on vitamin E alone or in combination with other vitamins or minerals were reviewed. Emphasis was placed on prospective, randomized, double-blind, placebo-controlled clinical trials. DATA SYNTHESIS: Eight clinical studies demonstrated contradicting results regarding the benefits of vitamin E in the prevention of cardiovascular disease and cancer. There is enough evidence from large, well-designed studies to discourage the use of vitamin E in the primary prevention of cardiovascular disease. Secondary prevention requires more adequate clinical trials with selected populations to examine protective effects of vitamin E in cardiovascular disease. The findings of the studies reviewed do not provide evidence that vitamin E may reduce the risk of cancer; thus, at the present time, we do not recommend daily vitamin E intake for cancer prevention is not recommended. CONCLUSIONS: Available data do not support the supplementation of vitamin E in cardiovascular disease and cancer prevention. SN - 1060-0280 UR - https://www.unboundmedicine.com/medline/citation/16189282/Vitamin_E_supplementation_in_cardiovascular_disease_and_cancer_prevention:_Part_1_ L2 - http://journals.sagepub.com/doi/full/10.1345/aph.1G211?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -