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Gabapentin provides effective postoperative analgesia whether administered pre-emptively or post-incision.
Can J Anaesth. 2005 Oct; 52(8):827-31.CJ

Abstract

PURPOSE

We investigated the effects of pre-incision and post-incision administration of gabapentin on postoperative pain and fentanyl consumption associated with open donor nephrectomy.

METHODS

Sixty ASA I subjects were randomly allocated into three groups to receive gabapentin 600 mg two hours before surgery and placebo after surgical incision (pre-incision group), placebo two hours before surgery and gabapentin 600 mg after surgical incision (post-incision group), or placebo two hours before surgery and after surgical incision (placebo group). After surgery, pain was assessed using a visual analogue scale (VAS), (1-10 cm) at time points 0, 6, 12, 18, and 24 hr. Subjects received patient-controlled-analgesia (fentanyl 1.0 microg x kg(-1) subject activated dose). Total fentanyl consumption in each group was recorded.

RESULTS

Subjects of pre-incision and post-incision groups had lower VAS scores at all time points (3.1 +/- 1.8, 2.9 +/- 1.3, 2.8 +/- 1.3, 2.5 +/- 0.9, 2.5 +/- 1.5 and 3.6 +/- 1.1, 3.0 +/- 1.2, 3.2 +/- 1.1, 2.9 +/- 1.0, 2.6 +/- 2.2) compared to placebo group (6.6 +/- 1.3, 5.0 +/- 1.0, 4.4 +/- 0.7, 4.2 +/- 0.8, 3.9 +/- 1.0). They also used less fentanyl (563.3 microg +/- 252.8 and 624.0 microg +/- 210.5 respectively) compared to placebo (924.7 microg +/- 417.5), (P < 0.05). No difference in total fentanyl consumption and pain scores at any time points were observed between pre- and post-incision groups.

CONCLUSION

Pre-incision administration of 600 mg gabapentin has no added benefit over post-incision administration in terms of pain scores and fentanyl consumption in subjects undergoing open donor nephrectomy.

Authors+Show Affiliations

Department of Anaesthesiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow 226014, India. ckpandey@sgpgi.ac.inNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16189334

Citation

Pandey, Chandra Kant, et al. "Gabapentin Provides Effective Postoperative Analgesia Whether Administered Pre-emptively or Post-incision." Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, vol. 52, no. 8, 2005, pp. 827-31.
Pandey CK, Singhal V, Kumar M, et al. Gabapentin provides effective postoperative analgesia whether administered pre-emptively or post-incision. Can J Anaesth. 2005;52(8):827-31.
Pandey, C. K., Singhal, V., Kumar, M., Lakra, A., Ranjan, R., Pal, R., Raza, M., Singh, U., & Singh, P. K. (2005). Gabapentin provides effective postoperative analgesia whether administered pre-emptively or post-incision. Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, 52(8), 827-31.
Pandey CK, et al. Gabapentin Provides Effective Postoperative Analgesia Whether Administered Pre-emptively or Post-incision. Can J Anaesth. 2005;52(8):827-31. PubMed PMID: 16189334.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gabapentin provides effective postoperative analgesia whether administered pre-emptively or post-incision. AU - Pandey,Chandra Kant, AU - Singhal,Vinay, AU - Kumar,Mukesh, AU - Lakra,Archana, AU - Ranjan,Rajeev, AU - Pal,Rashmi, AU - Raza,Mehdi, AU - Singh,Uttam, AU - Singh,Prabhat Kumar, PY - 2005/9/29/pubmed PY - 2006/2/1/medline PY - 2005/9/29/entrez SP - 827 EP - 31 JF - Canadian journal of anaesthesia = Journal canadien d'anesthesie JO - Can J Anaesth VL - 52 IS - 8 N2 - PURPOSE: We investigated the effects of pre-incision and post-incision administration of gabapentin on postoperative pain and fentanyl consumption associated with open donor nephrectomy. METHODS: Sixty ASA I subjects were randomly allocated into three groups to receive gabapentin 600 mg two hours before surgery and placebo after surgical incision (pre-incision group), placebo two hours before surgery and gabapentin 600 mg after surgical incision (post-incision group), or placebo two hours before surgery and after surgical incision (placebo group). After surgery, pain was assessed using a visual analogue scale (VAS), (1-10 cm) at time points 0, 6, 12, 18, and 24 hr. Subjects received patient-controlled-analgesia (fentanyl 1.0 microg x kg(-1) subject activated dose). Total fentanyl consumption in each group was recorded. RESULTS: Subjects of pre-incision and post-incision groups had lower VAS scores at all time points (3.1 +/- 1.8, 2.9 +/- 1.3, 2.8 +/- 1.3, 2.5 +/- 0.9, 2.5 +/- 1.5 and 3.6 +/- 1.1, 3.0 +/- 1.2, 3.2 +/- 1.1, 2.9 +/- 1.0, 2.6 +/- 2.2) compared to placebo group (6.6 +/- 1.3, 5.0 +/- 1.0, 4.4 +/- 0.7, 4.2 +/- 0.8, 3.9 +/- 1.0). They also used less fentanyl (563.3 microg +/- 252.8 and 624.0 microg +/- 210.5 respectively) compared to placebo (924.7 microg +/- 417.5), (P < 0.05). No difference in total fentanyl consumption and pain scores at any time points were observed between pre- and post-incision groups. CONCLUSION: Pre-incision administration of 600 mg gabapentin has no added benefit over post-incision administration in terms of pain scores and fentanyl consumption in subjects undergoing open donor nephrectomy. SN - 0832-610X UR - https://www.unboundmedicine.com/medline/citation/16189334/Gabapentin_provides_effective_postoperative_analgesia_whether_administered_pre_emptively_or_post_incision_ L2 - https://doi.org/10.1007/BF03021777 DB - PRIME DP - Unbound Medicine ER -