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Folate and vitamin B12 in relation to lactation: a 9-month postpartum follow-up study.
Eur J Clin Nutr. 2006 Jan; 60(1):120-8.EJ

Abstract

OBJECTIVE

To investigate the relation between lactation and markers of folate and vitamin B12 (B12) deficiency in women with and without vitamin supplementation.

DESIGN

A 9-month follow-up study.

SUBJECTS AND METHODS

Blood samples from 91 women, who gave birth to a single healthy child, were collected 3 weeks, 4 and 9 months postpartum and analysed for circulating level of homocysteine (tHcy), methylmalonic acid (MMA), folate and B12. The participants were categorized as exclusively, partly or not breast-feeding dependent on the degree of lactation 4 months postpartum. During follow-up, lifestyle factors were recorded by structured interviews.

RESULTS

Among 72 exclusively breast-feeding women, the median (10-90% percentile) tHcy was 5.8 (3.1-8.3) micromol/l 3 weeks postpartum, 6.1 (4.1-10.3) micromol/l 4 months postpartum and 5.3 (3.6-8.7) micromol/I 9 months postpartum. At 9 months postpartum, none of the women breast-fed exclusively. No significant change occurred in the concentration of B12 and folate. Exclusively breast-feeding women without vitamin supplementation had higher median tHcy than supplemented exclusively breast-feeding women 4 and 9 months postpartum (7.0 vs 5.4 micromol/l (P < 0.001) and 5.8 vs 4.5 micromol/l (P = 0.003), respectively). Six women had increased (>15 micromol/l) tHcy; four of these were unsupplemented and exclusively breast-feeding.

CONCLUSION

We found no overall indication of depletion of the folate and B12 stores during the lactation period in this population. However, folate-supplemented women had lower tHcy and higher folate levels, suggesting a beneficial effect of supplementation with folate throughout lactation.

Authors+Show Affiliations

Institute of Public Health, Department of Health Science, Aarhus University, Arhus, Denmark. craha@as.aaa.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16189550

Citation

Ramlau-Hansen, C H., et al. "Folate and Vitamin B12 in Relation to Lactation: a 9-month Postpartum Follow-up Study." European Journal of Clinical Nutrition, vol. 60, no. 1, 2006, pp. 120-8.
Ramlau-Hansen CH, Møller UK, Henriksen TB, et al. Folate and vitamin B12 in relation to lactation: a 9-month postpartum follow-up study. Eur J Clin Nutr. 2006;60(1):120-8.
Ramlau-Hansen, C. H., Møller, U. K., Henriksen, T. B., Nexø, E., & Møller, J. (2006). Folate and vitamin B12 in relation to lactation: a 9-month postpartum follow-up study. European Journal of Clinical Nutrition, 60(1), 120-8.
Ramlau-Hansen CH, et al. Folate and Vitamin B12 in Relation to Lactation: a 9-month Postpartum Follow-up Study. Eur J Clin Nutr. 2006;60(1):120-8. PubMed PMID: 16189550.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folate and vitamin B12 in relation to lactation: a 9-month postpartum follow-up study. AU - Ramlau-Hansen,C H, AU - Møller,U K, AU - Henriksen,T B, AU - Nexø,E, AU - Møller,J, PY - 2005/9/29/pubmed PY - 2006/4/21/medline PY - 2005/9/29/entrez SP - 120 EP - 8 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 60 IS - 1 N2 - OBJECTIVE: To investigate the relation between lactation and markers of folate and vitamin B12 (B12) deficiency in women with and without vitamin supplementation. DESIGN: A 9-month follow-up study. SUBJECTS AND METHODS: Blood samples from 91 women, who gave birth to a single healthy child, were collected 3 weeks, 4 and 9 months postpartum and analysed for circulating level of homocysteine (tHcy), methylmalonic acid (MMA), folate and B12. The participants were categorized as exclusively, partly or not breast-feeding dependent on the degree of lactation 4 months postpartum. During follow-up, lifestyle factors were recorded by structured interviews. RESULTS: Among 72 exclusively breast-feeding women, the median (10-90% percentile) tHcy was 5.8 (3.1-8.3) micromol/l 3 weeks postpartum, 6.1 (4.1-10.3) micromol/l 4 months postpartum and 5.3 (3.6-8.7) micromol/I 9 months postpartum. At 9 months postpartum, none of the women breast-fed exclusively. No significant change occurred in the concentration of B12 and folate. Exclusively breast-feeding women without vitamin supplementation had higher median tHcy than supplemented exclusively breast-feeding women 4 and 9 months postpartum (7.0 vs 5.4 micromol/l (P < 0.001) and 5.8 vs 4.5 micromol/l (P = 0.003), respectively). Six women had increased (>15 micromol/l) tHcy; four of these were unsupplemented and exclusively breast-feeding. CONCLUSION: We found no overall indication of depletion of the folate and B12 stores during the lactation period in this population. However, folate-supplemented women had lower tHcy and higher folate levels, suggesting a beneficial effect of supplementation with folate throughout lactation. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16189550/Folate_and_vitamin_B12_in_relation_to_lactation:_a_9_month_postpartum_follow_up_study_ DB - PRIME DP - Unbound Medicine ER -