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[Circulatory dysfunction syndrome associated with liver cirrhosis].
Przegl Epidemiol. 2005; 59(2):549-58.PE

Abstract

Splanchnic arterial relaxation is the most important pathology in systemic circulation of portal hypertensive patients. Progressive decline of splanchnic vascular resistance is responsible for development of circulatory dysfunction syndrome (CDS), associated with reduction of effective blood volume within central vascular compartment and compensatory stimulation of vasopressor and natrium retaining hormonal mechanisms. Advanced CDS is characterized by increased cardiac output, tachycardia and low arterial pressure. Complications of CDS have functional nature and comprise: renal failure (hepatorenal syndrome), respiratory failure in context of hepatopulmonary syndrome, cardiac insufficiency produced by portopulmonary hypertension or portal cardiomyopathy, hemorrhages from digestive tract caused by hypertensive portal gastropathy or derangements of brain perfusion. The management of CDS relies on adequate filling of vascular system (albumin), constriction of arterial splanchnic vessels (beta-blocker, analogs of vasopressin and somatostatin), reduction of cardiac output (beta-blocker) and giving support to local vasoprotective mechanisms (prostaglandins, nitric oxide, blockade of ET-A receptors).

Authors+Show Affiliations

Hartleb M
Katedra i Klinika Gastroenterologii, Slaska Akademia Medyczna w Katowicach. lakmus@poczta.wprost.pl

MeSH

Blood CirculationCardiac OutputCardiomyopathiesHumansHypertension, PortalLiverLiver CirrhosisRisk FactorsSplanchnic CirculationVasoconstriction

Pub Type(s)

English Abstract
Journal Article
Review

Language

pol

PubMed ID

16190566

Citation

Hartleb, Marek. "[Circulatory Dysfunction Syndrome Associated With Liver Cirrhosis]." Przeglad Epidemiologiczny, vol. 59, no. 2, 2005, pp. 549-58.
Hartleb M. [Circulatory dysfunction syndrome associated with liver cirrhosis]. Przegl Epidemiol. 2005;59(2):549-58.
Hartleb, M. (2005). [Circulatory dysfunction syndrome associated with liver cirrhosis]. Przeglad Epidemiologiczny, 59(2), 549-58.
Hartleb M. [Circulatory Dysfunction Syndrome Associated With Liver Cirrhosis]. Przegl Epidemiol. 2005;59(2):549-58. PubMed PMID: 16190566.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Circulatory dysfunction syndrome associated with liver cirrhosis]. A1 - Hartleb,Marek, PY - 2005/9/30/pubmed PY - 2005/12/13/medline PY - 2005/9/30/entrez SP - 549 EP - 58 JF - Przeglad epidemiologiczny JO - Przegl Epidemiol VL - 59 IS - 2 N2 - Splanchnic arterial relaxation is the most important pathology in systemic circulation of portal hypertensive patients. Progressive decline of splanchnic vascular resistance is responsible for development of circulatory dysfunction syndrome (CDS), associated with reduction of effective blood volume within central vascular compartment and compensatory stimulation of vasopressor and natrium retaining hormonal mechanisms. Advanced CDS is characterized by increased cardiac output, tachycardia and low arterial pressure. Complications of CDS have functional nature and comprise: renal failure (hepatorenal syndrome), respiratory failure in context of hepatopulmonary syndrome, cardiac insufficiency produced by portopulmonary hypertension or portal cardiomyopathy, hemorrhages from digestive tract caused by hypertensive portal gastropathy or derangements of brain perfusion. The management of CDS relies on adequate filling of vascular system (albumin), constriction of arterial splanchnic vessels (beta-blocker, analogs of vasopressin and somatostatin), reduction of cardiac output (beta-blocker) and giving support to local vasoprotective mechanisms (prostaglandins, nitric oxide, blockade of ET-A receptors). SN - 0033-2100 UR - https://www.unboundmedicine.com/medline/citation/16190566/[Circulatory_dysfunction_syndrome_associated_with_liver_cirrhosis]_ DB - PRIME DP - Unbound Medicine ER -