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Functional polymorphism of the NQO2 gene is associated with methamphetamine psychosis.
Addict Biol. 2005 Jun; 10(2):145-8.AB

Abstract

Several lines of evidence suggest that genetic factors contribute to the vulnerability of drug abuse such as methamphetamine (MAP), and that dopamine-quinones produced by administration of MAP may be involved in the mechanism of MAP-related symptoms. The detoxification of quinones is catalyzed by a family of proteins designated as quinone oxidoreductases (NQOs). We analysed the polymorphisms of NQO1 and NQO2 genes to elucidate the association with genetic vulnerability to MAP abuse in Japan. The genotype and allele frequencies for the polymorphism (Pro187Ser) of the NQO1 gene did not differ between each subgroup of patients and controls. In contrast, the genotype frequency for the insertion/deletion (I/D) polymorphism in the promoter region of the NQO2 gene was a significant (p = 0.038) difference between patients with prolonged-type MAP psychosis and controls. This study suggests that the NQO2 gene polymorphism contributes to the aetiology of MAP-related psychosis in Japanese.

Authors+Show Affiliations

Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16191666

Citation

Ohgake, Shintaro, et al. "Functional Polymorphism of the NQO2 Gene Is Associated With Methamphetamine Psychosis." Addiction Biology, vol. 10, no. 2, 2005, pp. 145-8.
Ohgake S, Hashimoto K, Shimizu E, et al. Functional polymorphism of the NQO2 gene is associated with methamphetamine psychosis. Addict Biol. 2005;10(2):145-8.
Ohgake, S., Hashimoto, K., Shimizu, E., Koizumi, H., Okamura, N., Koike, K., Matsuzawa, D., Sekine, Y., Inada, T., Ozaki, N., Iwata, N., Harano, M., Komiyama, T., Yamada, M., Sora, I., Ujike, H., Shirayama, Y., & Iyo, M. (2005). Functional polymorphism of the NQO2 gene is associated with methamphetamine psychosis. Addiction Biology, 10(2), 145-8.
Ohgake S, et al. Functional Polymorphism of the NQO2 Gene Is Associated With Methamphetamine Psychosis. Addict Biol. 2005;10(2):145-8. PubMed PMID: 16191666.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functional polymorphism of the NQO2 gene is associated with methamphetamine psychosis. AU - Ohgake,Shintaro, AU - Hashimoto,Kenji, AU - Shimizu,Eiji, AU - Koizumi,Hiroki, AU - Okamura,Naoe, AU - Koike,Kaori, AU - Matsuzawa,Daisuke, AU - Sekine,Yoshimoto, AU - Inada,Toshiya, AU - Ozaki,Norio, AU - Iwata,Nakao, AU - Harano,Mutsuo, AU - Komiyama,Tokutaro, AU - Yamada,Mitsuhiko, AU - Sora,Ichiro, AU - Ujike,Hiroshi, AU - Shirayama,Yukihiko, AU - Iyo,Masaomi, PY - 2005/9/30/pubmed PY - 2005/11/3/medline PY - 2005/9/30/entrez SP - 145 EP - 8 JF - Addiction biology JO - Addict Biol VL - 10 IS - 2 N2 - Several lines of evidence suggest that genetic factors contribute to the vulnerability of drug abuse such as methamphetamine (MAP), and that dopamine-quinones produced by administration of MAP may be involved in the mechanism of MAP-related symptoms. The detoxification of quinones is catalyzed by a family of proteins designated as quinone oxidoreductases (NQOs). We analysed the polymorphisms of NQO1 and NQO2 genes to elucidate the association with genetic vulnerability to MAP abuse in Japan. The genotype and allele frequencies for the polymorphism (Pro187Ser) of the NQO1 gene did not differ between each subgroup of patients and controls. In contrast, the genotype frequency for the insertion/deletion (I/D) polymorphism in the promoter region of the NQO2 gene was a significant (p = 0.038) difference between patients with prolonged-type MAP psychosis and controls. This study suggests that the NQO2 gene polymorphism contributes to the aetiology of MAP-related psychosis in Japanese. SN - 1355-6215 UR - https://www.unboundmedicine.com/medline/citation/16191666/Functional_polymorphism_of_the_NQO2_gene_is_associated_with_methamphetamine_psychosis_ L2 - https://doi.org/10.1080/13556210500123423 DB - PRIME DP - Unbound Medicine ER -