Tags

Type your tag names separated by a space and hit enter

Bath-water PUVA therapy with 8-methoxypsoralen in mycosis fungoides.
Acta Derm Venereol. 2005; 85(4):329-32.AD

Abstract

PUVA therapy is widely used for early stage mycosis fungoides. While the efficacy of PUVA with oral 8-methoxypsoralen (8-MOP) is well documented, the use of its topical variation, bath-water PUVA therapy with 8-MOP has not been studied. The purpose of this study was to assess the effect of 8-MOP bath-water PUVA therapy in adult patients with early stage mycosis fungoides. We retrospectively evaluated the outcomes of bath-water delivery of 8-MOP (1 mg l(-1)) in 16 patients with early stage mycosis fungoides. In all patients complete response was achieved after a mean duration of 63 days requiring 29 treatments and a mean cumulative UVA dose of 33 J cm(-2). The time to relapse after complete clinical clearance was 45.6 (+/-9.2) weeks. In comparison, oral PUVA therapy with 8-MOP resulted in complete response after 64.5 days (25.8 treatments) with a mean relapse-free period of 30 (+/-3.5) weeks. We conclude that bath-water PUVA therapy with 8-MOP is a valuable photo-therapeutic alternative, which should be considered for patients in whom systemic psoralen cannot be used.

Authors+Show Affiliations

Clinical Department of Dermatology and Venereology, Medical University of Innsbruck, Innsbruck, Austria. florian.weber@uibk.ac.atNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16191854

Citation

Weber, Florian, et al. "Bath-water PUVA Therapy With 8-methoxypsoralen in Mycosis Fungoides." Acta Dermato-venereologica, vol. 85, no. 4, 2005, pp. 329-32.
Weber F, Schmuth M, Sepp N, et al. Bath-water PUVA therapy with 8-methoxypsoralen in mycosis fungoides. Acta Derm Venereol. 2005;85(4):329-32.
Weber, F., Schmuth, M., Sepp, N., & Fritsch, P. (2005). Bath-water PUVA therapy with 8-methoxypsoralen in mycosis fungoides. Acta Dermato-venereologica, 85(4), 329-32.
Weber F, et al. Bath-water PUVA Therapy With 8-methoxypsoralen in Mycosis Fungoides. Acta Derm Venereol. 2005;85(4):329-32. PubMed PMID: 16191854.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bath-water PUVA therapy with 8-methoxypsoralen in mycosis fungoides. AU - Weber,Florian, AU - Schmuth,Matthias, AU - Sepp,Norbert, AU - Fritsch,Peter, PY - 2005/9/30/pubmed PY - 2005/10/14/medline PY - 2005/9/30/entrez SP - 329 EP - 32 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 85 IS - 4 N2 - PUVA therapy is widely used for early stage mycosis fungoides. While the efficacy of PUVA with oral 8-methoxypsoralen (8-MOP) is well documented, the use of its topical variation, bath-water PUVA therapy with 8-MOP has not been studied. The purpose of this study was to assess the effect of 8-MOP bath-water PUVA therapy in adult patients with early stage mycosis fungoides. We retrospectively evaluated the outcomes of bath-water delivery of 8-MOP (1 mg l(-1)) in 16 patients with early stage mycosis fungoides. In all patients complete response was achieved after a mean duration of 63 days requiring 29 treatments and a mean cumulative UVA dose of 33 J cm(-2). The time to relapse after complete clinical clearance was 45.6 (+/-9.2) weeks. In comparison, oral PUVA therapy with 8-MOP resulted in complete response after 64.5 days (25.8 treatments) with a mean relapse-free period of 30 (+/-3.5) weeks. We conclude that bath-water PUVA therapy with 8-MOP is a valuable photo-therapeutic alternative, which should be considered for patients in whom systemic psoralen cannot be used. SN - 0001-5555 UR - https://www.unboundmedicine.com/medline/citation/16191854/Bath_water_PUVA_therapy_with_8_methoxypsoralen_in_mycosis_fungoides_ L2 - https://www.medicaljournals.se/acta/content/abstract/10.1080/00015550510032814 DB - PRIME DP - Unbound Medicine ER -