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Medication use and risk of non-Hodgkin's lymphoma.

Abstract

Conflicting results from previous epidemiologic studies shed little light on whether medication use is associated with risk of non-Hodgkin's lymphoma (NHL). To investigate this question, the authors conducted a population-based case-control study in Denmark and Sweden from 1999 to 2002, including 3,055 incident NHL cases and 3,187 controls. Participants reported their past use of medications and history of particular medical conditions. Unconditional logistic regression was used to estimate multivariate odds ratios and 95% confidence intervals for the associations between medication use and risk of NHL; all statistical tests were two sided. Use of antibiotics more than 10 times during adulthood was positively associated with risk of NHL and most major NHL subtypes; when users were compared with nonusers, the odds ratio for NHL was 1.8 (95% confidence interval: 1.4, 2.3); p(trend) for total antibiotic use <0.001. In addition, high cumulative use of nonsteroidal anti-inflammatory drugs was marginally associated with elevated NHL risk. Other medications evaluated were not associated with risk of NHL or its most common subtypes. Findings suggest that inflammation, infections, susceptibility to infections, and/or use of antibiotics or nonsteroidal anti-inflammatory drugs to treat these conditions may increase the risk of NHL. However, most of the medications examined were not associated with NHL risk.

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  • Authors+Show Affiliations

    ,

    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. ellen.chang@ki.se

    , , , , , , , , ,

    Source

    American journal of epidemiology 162:10 2005 Nov 15 pg 965-74

    MeSH

    Adolescent
    Adrenal Cortex Hormones
    Adult
    Aged
    Anti-Bacterial Agents
    Anti-Inflammatory Agents, Non-Steroidal
    Anticonvulsants
    Case-Control Studies
    Denmark
    Dose-Response Relationship, Drug
    Drug Utilization
    Female
    Histamine Antagonists
    Humans
    Lymphoma, Non-Hodgkin
    Male
    Middle Aged
    Odds Ratio
    Risk Factors
    Sex Distribution
    Sweden

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16192343

    Citation

    Chang, Ellen T., et al. "Medication Use and Risk of non-Hodgkin's Lymphoma." American Journal of Epidemiology, vol. 162, no. 10, 2005, pp. 965-74.
    Chang ET, Smedby KE, Hjalgrim H, et al. Medication use and risk of non-Hodgkin's lymphoma. Am J Epidemiol. 2005;162(10):965-74.
    Chang, E. T., Smedby, K. E., Hjalgrim, H., Schöllkopf, C., Porwit-MacDonald, A., Sundström, C., ... Glimelius, B. (2005). Medication use and risk of non-Hodgkin's lymphoma. American Journal of Epidemiology, 162(10), pp. 965-74.
    Chang ET, et al. Medication Use and Risk of non-Hodgkin's Lymphoma. Am J Epidemiol. 2005 Nov 15;162(10):965-74. PubMed PMID: 16192343.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Medication use and risk of non-Hodgkin's lymphoma. AU - Chang,Ellen T, AU - Smedby,Karin Ekström, AU - Hjalgrim,Henrik, AU - Schöllkopf,Claudia, AU - Porwit-MacDonald,Anna, AU - Sundström,Christer, AU - Tani,Edneia, AU - d'Amore,Francesco, AU - Melbye,Mads, AU - Adami,Hans-Olov, AU - Glimelius,Bengt, Y1 - 2005/09/28/ PY - 2005/9/30/pubmed PY - 2006/1/20/medline PY - 2005/9/30/entrez SP - 965 EP - 74 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 162 IS - 10 N2 - Conflicting results from previous epidemiologic studies shed little light on whether medication use is associated with risk of non-Hodgkin's lymphoma (NHL). To investigate this question, the authors conducted a population-based case-control study in Denmark and Sweden from 1999 to 2002, including 3,055 incident NHL cases and 3,187 controls. Participants reported their past use of medications and history of particular medical conditions. Unconditional logistic regression was used to estimate multivariate odds ratios and 95% confidence intervals for the associations between medication use and risk of NHL; all statistical tests were two sided. Use of antibiotics more than 10 times during adulthood was positively associated with risk of NHL and most major NHL subtypes; when users were compared with nonusers, the odds ratio for NHL was 1.8 (95% confidence interval: 1.4, 2.3); p(trend) for total antibiotic use <0.001. In addition, high cumulative use of nonsteroidal anti-inflammatory drugs was marginally associated with elevated NHL risk. Other medications evaluated were not associated with risk of NHL or its most common subtypes. Findings suggest that inflammation, infections, susceptibility to infections, and/or use of antibiotics or nonsteroidal anti-inflammatory drugs to treat these conditions may increase the risk of NHL. However, most of the medications examined were not associated with NHL risk. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/16192343/Medication_use_and_risk_of_non_Hodgkin's_lymphoma_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwi311 DB - PRIME DP - Unbound Medicine ER -