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Parental occupational exposure to pesticides and childhood germ-cell tumors.
Am J Epidemiol. 2005 Nov 01; 162(9):858-67.AJ

Abstract

In a recently completed US case-control study (Children's Oncology Group, 1993-2001) with 253 cases and 394 controls, the authors investigated the association between parental occupational exposure to pesticides and risk of childhood germ-cell tumors. Information on occupational pesticide exposure was collected using job-specific module questionnaires and assessed by an experienced industrial hygienist. Odds ratios for childhood germ-cell tumors associated with maternal exposures before pregnancy, during pregnancy, and after the birth of the index child were 1.0 (95% confidence interval (CI): 0.8, 1.4), 1.1 (95% CI: 0.7, 1.6), and 1.3 (95% CI: 0.9, 1.8), respectively. Paternal exposures before pregnancy, during pregnancy, and after the birth of the index child were not related to germ-cell tumors (odds ratios (ORs) were 0.9 (95% CI: 0.7, 1.2), 0.8 (95% CI: 0.5, 1.2), and 0.8 (95% CI: 0.5, 1.3), respectively). When both parents had ever been occupationally exposed to pesticides before the index pregnancy, the odds ratio was 0.8 (95% CI: 0.4, 1.3). Subgroup analyses showed a positive association between maternal exposure to herbicides during the postnatal period and risk of germ-cell tumors in girls (OR = 2.3, 95% CI: 1.0, 5.2) and an inverse association between paternal exposure to pesticides during the index pregnancy and germ-cell tumors in boys (OR = 0.2, 95% CI: 0.1, 1.0). This study did not provide strong evidence supporting a relation between parental pesticide exposure in the workplace and risk of germ-cell tumors among offspring.

Authors+Show Affiliations

Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16192347

Citation

Chen, Zhi, et al. "Parental Occupational Exposure to Pesticides and Childhood Germ-cell Tumors." American Journal of Epidemiology, vol. 162, no. 9, 2005, pp. 858-67.
Chen Z, Stewart PA, Davies S, et al. Parental occupational exposure to pesticides and childhood germ-cell tumors. Am J Epidemiol. 2005;162(9):858-67.
Chen, Z., Stewart, P. A., Davies, S., Giller, R., Krailo, M., Davis, M., Robison, L., & Shu, X. O. (2005). Parental occupational exposure to pesticides and childhood germ-cell tumors. American Journal of Epidemiology, 162(9), 858-67.
Chen Z, et al. Parental Occupational Exposure to Pesticides and Childhood Germ-cell Tumors. Am J Epidemiol. 2005 Nov 1;162(9):858-67. PubMed PMID: 16192347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parental occupational exposure to pesticides and childhood germ-cell tumors. AU - Chen,Zhi, AU - Stewart,Patricia A, AU - Davies,Stella, AU - Giller,Roger, AU - Krailo,Mark, AU - Davis,Mary, AU - Robison,Leslie, AU - Shu,Xiao-Ou, Y1 - 2005/09/28/ PY - 2005/9/30/pubmed PY - 2005/12/13/medline PY - 2005/9/30/entrez SP - 858 EP - 67 JF - American journal of epidemiology JO - Am J Epidemiol VL - 162 IS - 9 N2 - In a recently completed US case-control study (Children's Oncology Group, 1993-2001) with 253 cases and 394 controls, the authors investigated the association between parental occupational exposure to pesticides and risk of childhood germ-cell tumors. Information on occupational pesticide exposure was collected using job-specific module questionnaires and assessed by an experienced industrial hygienist. Odds ratios for childhood germ-cell tumors associated with maternal exposures before pregnancy, during pregnancy, and after the birth of the index child were 1.0 (95% confidence interval (CI): 0.8, 1.4), 1.1 (95% CI: 0.7, 1.6), and 1.3 (95% CI: 0.9, 1.8), respectively. Paternal exposures before pregnancy, during pregnancy, and after the birth of the index child were not related to germ-cell tumors (odds ratios (ORs) were 0.9 (95% CI: 0.7, 1.2), 0.8 (95% CI: 0.5, 1.2), and 0.8 (95% CI: 0.5, 1.3), respectively). When both parents had ever been occupationally exposed to pesticides before the index pregnancy, the odds ratio was 0.8 (95% CI: 0.4, 1.3). Subgroup analyses showed a positive association between maternal exposure to herbicides during the postnatal period and risk of germ-cell tumors in girls (OR = 2.3, 95% CI: 1.0, 5.2) and an inverse association between paternal exposure to pesticides during the index pregnancy and germ-cell tumors in boys (OR = 0.2, 95% CI: 0.1, 1.0). This study did not provide strong evidence supporting a relation between parental pesticide exposure in the workplace and risk of germ-cell tumors among offspring. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/16192347/Parental_occupational_exposure_to_pesticides_and_childhood_germ_cell_tumors_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwi294 DB - PRIME DP - Unbound Medicine ER -