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Use of Swedish moist snuff, smoking and alcohol consumption in the aetiology of oral and oropharyngeal squamous cell carcinoma. A population-based case-control study in southern Sweden.
Acta Otolaryngol 2005; 125(9):991-8AO

Abstract

CONCLUSIONS

The results of this study confirm that both smoking of tobacco and alcohol consumption are risk factors for oral and oropharyngeal squamous cell carcinoma (OOSCC). The use of moist snuff had no effect on the risk of OOSCC, probably due to the low levels of tobacco-specific N-nitrosamines in Swedish moist snuff.

OBJECTIVE

The aims of this population-based case-control study in southern Sweden were to establish risk estimates for cigarette and alcohol consumption and to evaluate whether Swedish moist snuff is a risk factor for OOSCC.

MATERIAL AND METHODS

Between September 2000 and January 2004, 132/165 consecutive cases (80%) diagnosed with OOSCC and 320/396 matched controls (81%) were investigated. All subjects were interviewed and examined according to a standardized protocol.

RESULTS

Individuals who drank > or =350 g of alcohol/week showed an increased risk of OOSCC (OR 2.6; 95% CI 1.3-5.4). Total lifetime consumption of tobacco for smoking (>250 kg) had a dose-response effect on the risk of OOSCC (OR 4.7; 95% CI 2.4-9.1). We found no increased risk of OOSCC associated with the use of Swedish moist snuff (OR 1.1; 95% CI 0.5-2.5).

Authors+Show Affiliations

Department of Oral Surgery and Oral Medicine, Faculty of Odontology, Malmö University, Malmö, Sweden. Kerstin.Rosenquist@od.mah.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16193590

Citation

Rosenquist, Kerstin, et al. "Use of Swedish Moist Snuff, Smoking and Alcohol Consumption in the Aetiology of Oral and Oropharyngeal Squamous Cell Carcinoma. a Population-based Case-control Study in Southern Sweden." Acta Oto-laryngologica, vol. 125, no. 9, 2005, pp. 991-8.
Rosenquist K, Wennerberg J, Schildt EB, et al. Use of Swedish moist snuff, smoking and alcohol consumption in the aetiology of oral and oropharyngeal squamous cell carcinoma. A population-based case-control study in southern Sweden. Acta Otolaryngol. 2005;125(9):991-8.
Rosenquist, K., Wennerberg, J., Schildt, E. B., Bladström, A., Hansson, B. G., & Andersson, G. (2005). Use of Swedish moist snuff, smoking and alcohol consumption in the aetiology of oral and oropharyngeal squamous cell carcinoma. A population-based case-control study in southern Sweden. Acta Oto-laryngologica, 125(9), pp. 991-8.
Rosenquist K, et al. Use of Swedish Moist Snuff, Smoking and Alcohol Consumption in the Aetiology of Oral and Oropharyngeal Squamous Cell Carcinoma. a Population-based Case-control Study in Southern Sweden. Acta Otolaryngol. 2005;125(9):991-8. PubMed PMID: 16193590.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of Swedish moist snuff, smoking and alcohol consumption in the aetiology of oral and oropharyngeal squamous cell carcinoma. A population-based case-control study in southern Sweden. AU - Rosenquist,Kerstin, AU - Wennerberg,Johan, AU - Schildt,Elsy-Britt, AU - Bladström,Anna, AU - Hansson,Bengt Göran, AU - Andersson,Gunilla, PY - 2005/10/1/pubmed PY - 2005/12/31/medline PY - 2005/10/1/entrez SP - 991 EP - 8 JF - Acta oto-laryngologica JO - Acta Otolaryngol. VL - 125 IS - 9 N2 - CONCLUSIONS: The results of this study confirm that both smoking of tobacco and alcohol consumption are risk factors for oral and oropharyngeal squamous cell carcinoma (OOSCC). The use of moist snuff had no effect on the risk of OOSCC, probably due to the low levels of tobacco-specific N-nitrosamines in Swedish moist snuff. OBJECTIVE: The aims of this population-based case-control study in southern Sweden were to establish risk estimates for cigarette and alcohol consumption and to evaluate whether Swedish moist snuff is a risk factor for OOSCC. MATERIAL AND METHODS: Between September 2000 and January 2004, 132/165 consecutive cases (80%) diagnosed with OOSCC and 320/396 matched controls (81%) were investigated. All subjects were interviewed and examined according to a standardized protocol. RESULTS: Individuals who drank > or =350 g of alcohol/week showed an increased risk of OOSCC (OR 2.6; 95% CI 1.3-5.4). Total lifetime consumption of tobacco for smoking (>250 kg) had a dose-response effect on the risk of OOSCC (OR 4.7; 95% CI 2.4-9.1). We found no increased risk of OOSCC associated with the use of Swedish moist snuff (OR 1.1; 95% CI 0.5-2.5). SN - 0001-6489 UR - https://www.unboundmedicine.com/medline/citation/16193590/Use_of_Swedish_moist_snuff_smoking_and_alcohol_consumption_in_the_aetiology_of_oral_and_oropharyngeal_squamous_cell_carcinoma__A_population_based_case_control_study_in_southern_Sweden_ L2 - http://www.tandfonline.com/doi/full/10.1080/00016480510043440 DB - PRIME DP - Unbound Medicine ER -