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Non-uniformity in the regional pattern of Lewy pathology in brains of dementia with Lewy bodies.
Neuropathology. 2005 Sep; 25(3):188-94.N

Abstract

We examined the regional pattern of Lewy pathology in brains of dementia with Lewy bodies (DLB) to clarify whether Lewy pathology uniformly progresses or not. Thirty-five autopsied DLB cases were examined using alpha-synuclein-immunohistochemistry, and the regional degree of Lewy pathology in the brainstem, diencephalon and cerebral cortex was quantitatively evaluated. Consequently, we found that the regional pattern of Lewy pathology differed according to the pathological subtype, and was divided into three types: type 1 showed a brainstem-predominant pattern, type 2 was almost equal for the brainstem and cerebral cortex, and type 3 showed a cerebral cortex-predominant pattern. The limbic type/pure and common forms were mainly composed of type 1, whereas the neocortical type/common and Alzheimer's disease (AD) forms were mainly composed of type 3. These findings suggest the possibility that Lewy pathology of the limbic type/pure and common forms mainly progresses from the brainstem to the cerebrum, whereas that of the neocortical type/common and AD forms mainly progresses from the cerebrum to the brainstem. Cases with type 1 Lewy pathology mainly developed parkinsonism, whereas those with type 3 Lewy pathology mainly developed dementia. This corresponded to most of the limbic type/ pure and common forms which developed parkinsonism, whereas most of the neocortical type/common and AD forms developed dementia. Type 1 cases may thus be clinically diagnosed as having Parkinson's disease (PD) with dementia. These findings suggest that PD has clinico-pathological continuity with DLB, and that the regional pattern of Lewy pathology is not uniform.

Authors+Show Affiliations

Department of Psychiatry, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, Koto-ku, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16193834

Citation

Yamamoto, Ryoko, et al. "Non-uniformity in the Regional Pattern of Lewy Pathology in Brains of Dementia With Lewy Bodies." Neuropathology : Official Journal of the Japanese Society of Neuropathology, vol. 25, no. 3, 2005, pp. 188-94.
Yamamoto R, Iseki E, Marui W, et al. Non-uniformity in the regional pattern of Lewy pathology in brains of dementia with Lewy bodies. Neuropathology. 2005;25(3):188-94.
Yamamoto, R., Iseki, E., Marui, W., Togo, T., Katsuse, O., Kato, M., Isojima, D., Akatsu, H., Kosaka, K., & Arai, H. (2005). Non-uniformity in the regional pattern of Lewy pathology in brains of dementia with Lewy bodies. Neuropathology : Official Journal of the Japanese Society of Neuropathology, 25(3), 188-94.
Yamamoto R, et al. Non-uniformity in the Regional Pattern of Lewy Pathology in Brains of Dementia With Lewy Bodies. Neuropathology. 2005;25(3):188-94. PubMed PMID: 16193834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-uniformity in the regional pattern of Lewy pathology in brains of dementia with Lewy bodies. AU - Yamamoto,Ryoko, AU - Iseki,Eizo, AU - Marui,Wami, AU - Togo,Takashi, AU - Katsuse,Omi, AU - Kato,Masanori, AU - Isojima,Daisuke, AU - Akatsu,Hiroyasu, AU - Kosaka,Kenji, AU - Arai,Heii, PY - 2005/10/1/pubmed PY - 2005/10/28/medline PY - 2005/10/1/entrez SP - 188 EP - 94 JF - Neuropathology : official journal of the Japanese Society of Neuropathology JO - Neuropathology VL - 25 IS - 3 N2 - We examined the regional pattern of Lewy pathology in brains of dementia with Lewy bodies (DLB) to clarify whether Lewy pathology uniformly progresses or not. Thirty-five autopsied DLB cases were examined using alpha-synuclein-immunohistochemistry, and the regional degree of Lewy pathology in the brainstem, diencephalon and cerebral cortex was quantitatively evaluated. Consequently, we found that the regional pattern of Lewy pathology differed according to the pathological subtype, and was divided into three types: type 1 showed a brainstem-predominant pattern, type 2 was almost equal for the brainstem and cerebral cortex, and type 3 showed a cerebral cortex-predominant pattern. The limbic type/pure and common forms were mainly composed of type 1, whereas the neocortical type/common and Alzheimer's disease (AD) forms were mainly composed of type 3. These findings suggest the possibility that Lewy pathology of the limbic type/pure and common forms mainly progresses from the brainstem to the cerebrum, whereas that of the neocortical type/common and AD forms mainly progresses from the cerebrum to the brainstem. Cases with type 1 Lewy pathology mainly developed parkinsonism, whereas those with type 3 Lewy pathology mainly developed dementia. This corresponded to most of the limbic type/ pure and common forms which developed parkinsonism, whereas most of the neocortical type/common and AD forms developed dementia. Type 1 cases may thus be clinically diagnosed as having Parkinson's disease (PD) with dementia. These findings suggest that PD has clinico-pathological continuity with DLB, and that the regional pattern of Lewy pathology is not uniform. SN - 0919-6544 UR - https://www.unboundmedicine.com/medline/citation/16193834/Non_uniformity_in_the_regional_pattern_of_Lewy_pathology_in_brains_of_dementia_with_Lewy_bodies_ L2 - https://doi.org/10.1111/j.1440-1789.2005.00627.x DB - PRIME DP - Unbound Medicine ER -