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["Lues maligna" in a female patient with diabetes].
J Dtsch Dermatol Ges. 2005 Oct; 3(10):780-2.JD

Abstract

A 40-year-old female patient with diabetes mellitus presented with multiple erythematous ulcerated nodules and plaques predominantly on the trunk. A few months ago her partner had a small ulcer on the penis. She was HIV negative but showed markedly elevated syphilis serology titers (TPPA titer > 1:20.480, VDRL titer 1:128). The serum glucose levels exceeded 275 mg/dl. After exclusion of neurological involvement, we made the diagnosis of "lues maligna" arising in the setting of diabetes mellitus. The patient was treated with 2.4 million units benzathine penicillin intramuscularly weekly for three weeks. Simultaneously, diabetes therapy was improved with insulin injections. The syphilitic lesions cleared rapidly. In the follow-up VDRL titer was negative. "Lues maligna" is an unusual ulcerative variant of secondary syphilis which has been observed more frequently in HIV-infected patients in the last years. The occurrence of this aggressive variant in the clinical setting of diabetes mellitus is extremely rare.

Authors+Show Affiliations

Klinik und Poliklinik für Haut- und Geschlechtskrankheiten, Universitätsklinikum Würzburg. hofmann_u1@klinik.uni-wuerzburg.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

ger

PubMed ID

16194156

Citation

Hofmann, Uta B., et al. "["Lues Maligna" in a Female Patient With Diabetes]." Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, vol. 3, no. 10, 2005, pp. 780-2.
Hofmann UB, Hund M, Bröcker EB, et al. ["Lues maligna" in a female patient with diabetes]. J Dtsch Dermatol Ges. 2005;3(10):780-2.
Hofmann, U. B., Hund, M., Bröcker, E. B., & Hamm, H. (2005). ["Lues maligna" in a female patient with diabetes]. Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 3(10), 780-2.
Hofmann UB, et al. ["Lues Maligna" in a Female Patient With Diabetes]. J Dtsch Dermatol Ges. 2005;3(10):780-2. PubMed PMID: 16194156.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ["Lues maligna" in a female patient with diabetes]. AU - Hofmann,Uta B, AU - Hund,Martina, AU - Bröcker,Eva-Bettina, AU - Hamm,Henning, PY - 2005/10/1/pubmed PY - 2005/12/28/medline PY - 2005/10/1/entrez SP - 780 EP - 2 JF - Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG JO - J Dtsch Dermatol Ges VL - 3 IS - 10 N2 - A 40-year-old female patient with diabetes mellitus presented with multiple erythematous ulcerated nodules and plaques predominantly on the trunk. A few months ago her partner had a small ulcer on the penis. She was HIV negative but showed markedly elevated syphilis serology titers (TPPA titer > 1:20.480, VDRL titer 1:128). The serum glucose levels exceeded 275 mg/dl. After exclusion of neurological involvement, we made the diagnosis of "lues maligna" arising in the setting of diabetes mellitus. The patient was treated with 2.4 million units benzathine penicillin intramuscularly weekly for three weeks. Simultaneously, diabetes therapy was improved with insulin injections. The syphilitic lesions cleared rapidly. In the follow-up VDRL titer was negative. "Lues maligna" is an unusual ulcerative variant of secondary syphilis which has been observed more frequently in HIV-infected patients in the last years. The occurrence of this aggressive variant in the clinical setting of diabetes mellitus is extremely rare. SN - 1610-0379 UR - https://www.unboundmedicine.com/medline/citation/16194156/["Lues_maligna"_in_a_female_patient_with_diabetes]_ L2 - https://doi.org/10.1111/j.1610-0387.2005.05734.x DB - PRIME DP - Unbound Medicine ER -