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Predictors of elevated blood lead levels among 3-year-old Ukrainian children: a nested case-control study.
Environ Res. 2005 Oct; 99(2):235-42.ER

Abstract

OBJECTIVES

Lead is common in the general population. However, data are lacking for the Ukraine and many other countries from the former Soviet Union (FSU). In this study we evaluate the level of blood lead among 212 Ukrainian children and determine predictors of elevated lead levels. We also describe the health effects associated with elevated blood lead.

METHODS

A nested case-control study from a prospective cohort of Ukrainian 3-year-old children was conducted in March 1998. Blood assays were analyzed for lead by labs at the Centers for Disease Control and using portable examination kits. We evaluated predictors of elevated blood lead (blood levels in the upper quartile >4.65 microg/dL) using a multivariable logistic regression model. The model included socioeconomic status, parent occupation, environmental tobacco smoke, hygiene, diet, and health status.

RESULTS

The geometric mean lead level was 3.15 microg/dL (range, 0.7--22.7). In our adjusted model, we observed a strong association between lead levels in the upper quartile and children whose fathers worked manual labor jobs in industries associated with lead exposures [adjusted odds ratio (OR)=2.25; P=0.025] and mothers who smoke indoors (adjusted OR=2.87; P=0.047). Daily hygiene and dietary habits were not associated with elevated lead levels. No increased risks of overall morbidity or lead-associated illness were observed (anemia, dental caries, renal disease, cardiovascular diseases, and musculoskeletal complaints).

CONCLUSION

This is the first study to describe lead levels and associated variables among Ukrainian children in the peer-reviewed literature. Elevated lead levels in these children were associated with paternal occupation and mothers smoking indoors. At age 3 no adverse health effects were observed. More data are needed to determine the level of heavy metal contamination in children from the Ukraine and many other former Soviet nation-states.

Authors+Show Affiliations

University of Illinois, School of Public Health, Division of Environmental and Occupational Health Sciences, Chicago, IL 60612, USA. spri@sbcglobal.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16194673

Citation

Friedman, L S., et al. "Predictors of Elevated Blood Lead Levels Among 3-year-old Ukrainian Children: a Nested Case-control Study." Environmental Research, vol. 99, no. 2, 2005, pp. 235-42.
Friedman LS, Lukyanova OM, Kundiev YI, et al. Predictors of elevated blood lead levels among 3-year-old Ukrainian children: a nested case-control study. Environ Res. 2005;99(2):235-42.
Friedman, L. S., Lukyanova, O. M., Kundiev, Y. I., Shkiryak-Nizhnyk, Z. A., Chislovska, N. V., Mucha, A., Zvinchuk, A. V., Oliynyk, I., & Hryhorczuk, D. (2005). Predictors of elevated blood lead levels among 3-year-old Ukrainian children: a nested case-control study. Environmental Research, 99(2), 235-42.
Friedman LS, et al. Predictors of Elevated Blood Lead Levels Among 3-year-old Ukrainian Children: a Nested Case-control Study. Environ Res. 2005;99(2):235-42. PubMed PMID: 16194673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictors of elevated blood lead levels among 3-year-old Ukrainian children: a nested case-control study. AU - Friedman,L S, AU - Lukyanova,O M, AU - Kundiev,Y I, AU - Shkiryak-Nizhnyk,Z A, AU - Chislovska,N V, AU - Mucha,A, AU - Zvinchuk,A V, AU - Oliynyk,I, AU - Hryhorczuk,D, Y1 - 2005/01/21/ PY - 2004/08/13/received PY - 2004/11/29/revised PY - 2004/12/06/accepted PY - 2005/10/1/pubmed PY - 2005/12/13/medline PY - 2005/10/1/entrez SP - 235 EP - 42 JF - Environmental research JO - Environ Res VL - 99 IS - 2 N2 - OBJECTIVES: Lead is common in the general population. However, data are lacking for the Ukraine and many other countries from the former Soviet Union (FSU). In this study we evaluate the level of blood lead among 212 Ukrainian children and determine predictors of elevated lead levels. We also describe the health effects associated with elevated blood lead. METHODS: A nested case-control study from a prospective cohort of Ukrainian 3-year-old children was conducted in March 1998. Blood assays were analyzed for lead by labs at the Centers for Disease Control and using portable examination kits. We evaluated predictors of elevated blood lead (blood levels in the upper quartile >4.65 microg/dL) using a multivariable logistic regression model. The model included socioeconomic status, parent occupation, environmental tobacco smoke, hygiene, diet, and health status. RESULTS: The geometric mean lead level was 3.15 microg/dL (range, 0.7--22.7). In our adjusted model, we observed a strong association between lead levels in the upper quartile and children whose fathers worked manual labor jobs in industries associated with lead exposures [adjusted odds ratio (OR)=2.25; P=0.025] and mothers who smoke indoors (adjusted OR=2.87; P=0.047). Daily hygiene and dietary habits were not associated with elevated lead levels. No increased risks of overall morbidity or lead-associated illness were observed (anemia, dental caries, renal disease, cardiovascular diseases, and musculoskeletal complaints). CONCLUSION: This is the first study to describe lead levels and associated variables among Ukrainian children in the peer-reviewed literature. Elevated lead levels in these children were associated with paternal occupation and mothers smoking indoors. At age 3 no adverse health effects were observed. More data are needed to determine the level of heavy metal contamination in children from the Ukraine and many other former Soviet nation-states. SN - 0013-9351 UR - https://www.unboundmedicine.com/medline/citation/16194673/Predictors_of_elevated_blood_lead_levels_among_3_year_old_Ukrainian_children:_a_nested_case_control_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(04)00243-9 DB - PRIME DP - Unbound Medicine ER -