Tags

Type your tag names separated by a space and hit enter

Effect of genistein on DMBA-induced oral carcinogenesis in hamster.
Carcinogenesis. 2006 Mar; 27(3):578-83.C

Abstract

Genistein, an isoflavone present in soy at high concentrations and being considered the primary antitumor constituent in soy, has been known to be a natural anticancer agent in in vitro studies and experimental animal models. The present study was aimed to investigate the putative chemopreventive effect of genistein on oral carcinogenesis in hamster cheek pouch at the post-initiation stage, as well as its effect on angiogenesis during this process. DMBA solution (0.5% in mineral oil) was applied topically to the left cheek pouch of male Syrian golden hamsters three times a week for 6 weeks. Two days after the last treatment of DMBA, genistein suspended in distilled water (10 mg/kg body Wt/day) or same volume of distilled water was administered into the animals by gavage daily for 12 weeks. The genistein treatment decreased the visible oral tumor incidence to 40.7 (11/27) from 53.6% (15/28) of the positive control, but the difference was not statistically significant (P = 0.34). And no significant difference in the average number of tumors/tumor-bearing hamster, the average tumor volume, or latency was observed between the control and the genistein-treated group. Vascular density in OSCC of the genistein-treated group and that of the control group was similar and there was no significant difference. Importantly, three animals in the genistein-treated group produced poorly-differenciated fibrosarcomas in the DMBA-painted cheek pouches. The exact mechanism behind this needs further investigation. In conclusion, no inhibitory effect of genistein on chemically-induced post-initiation stage of oral carcinogenesis was observed in the present study. On the contrary, genistein appeared to promote oral submucosa stroma tumorigenesis in concert with DMBA. So caution should be warranted for people with predisposition to oral cancer.

Authors+Show Affiliations

Department of Oral Medicine, Affiliated Ninth People's Hospital, School of Stomatology, Shanghai Jiaotong University, Shanghai Institute of Stomatology, Shanghai 200011, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16195236

Citation

Yang, Ya, et al. "Effect of Genistein On DMBA-induced Oral Carcinogenesis in Hamster." Carcinogenesis, vol. 27, no. 3, 2006, pp. 578-83.
Yang Y, Zhou ZT, Ge JP. Effect of genistein on DMBA-induced oral carcinogenesis in hamster. Carcinogenesis. 2006;27(3):578-83.
Yang, Y., Zhou, Z. T., & Ge, J. P. (2006). Effect of genistein on DMBA-induced oral carcinogenesis in hamster. Carcinogenesis, 27(3), 578-83.
Yang Y, Zhou ZT, Ge JP. Effect of Genistein On DMBA-induced Oral Carcinogenesis in Hamster. Carcinogenesis. 2006;27(3):578-83. PubMed PMID: 16195236.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of genistein on DMBA-induced oral carcinogenesis in hamster. AU - Yang,Ya, AU - Zhou,Zeng Tong, AU - Ge,Jian Ping, Y1 - 2005/09/29/ PY - 2005/10/1/pubmed PY - 2006/4/6/medline PY - 2005/10/1/entrez SP - 578 EP - 83 JF - Carcinogenesis JO - Carcinogenesis VL - 27 IS - 3 N2 - Genistein, an isoflavone present in soy at high concentrations and being considered the primary antitumor constituent in soy, has been known to be a natural anticancer agent in in vitro studies and experimental animal models. The present study was aimed to investigate the putative chemopreventive effect of genistein on oral carcinogenesis in hamster cheek pouch at the post-initiation stage, as well as its effect on angiogenesis during this process. DMBA solution (0.5% in mineral oil) was applied topically to the left cheek pouch of male Syrian golden hamsters three times a week for 6 weeks. Two days after the last treatment of DMBA, genistein suspended in distilled water (10 mg/kg body Wt/day) or same volume of distilled water was administered into the animals by gavage daily for 12 weeks. The genistein treatment decreased the visible oral tumor incidence to 40.7 (11/27) from 53.6% (15/28) of the positive control, but the difference was not statistically significant (P = 0.34). And no significant difference in the average number of tumors/tumor-bearing hamster, the average tumor volume, or latency was observed between the control and the genistein-treated group. Vascular density in OSCC of the genistein-treated group and that of the control group was similar and there was no significant difference. Importantly, three animals in the genistein-treated group produced poorly-differenciated fibrosarcomas in the DMBA-painted cheek pouches. The exact mechanism behind this needs further investigation. In conclusion, no inhibitory effect of genistein on chemically-induced post-initiation stage of oral carcinogenesis was observed in the present study. On the contrary, genistein appeared to promote oral submucosa stroma tumorigenesis in concert with DMBA. So caution should be warranted for people with predisposition to oral cancer. SN - 0143-3334 UR - https://www.unboundmedicine.com/medline/citation/16195236/Effect_of_genistein_on_DMBA_induced_oral_carcinogenesis_in_hamster_ L2 - https://academic.oup.com/carcin/article-lookup/doi/10.1093/carcin/bgi234 DB - PRIME DP - Unbound Medicine ER -