Tags

Type your tag names separated by a space and hit enter

Delayed in vivo catabolism of intermediate-density lipoprotein and low-density lipoprotein in hemodialysis patients as potential cause of premature atherosclerosis.
Arterioscler Thromb Vasc Biol 2005; 25(12):2615-22AT

Abstract

OBJECTIVE

Premature cardiovascular disease is the leading cause of death in patients with end-stage renal disease treated by hemodialysis (HD). Low-density lipoprotein (LDL) levels are not generally increased in HD patients, but their LDL metabolism is still poorly understood. We therefore investigated the in vivo metabolism of apoB-containing lipoproteins in two different ethnic populations of HD patients and controls.

METHODS AND RESULTS

We performed stable isotope kinetic studies using a primed constant infusion of deuterated leucine in 12 HD patients and 13 healthy controls. Tracer/tracee ratio of apoB was determined by means of gas chromatography/mass spectrometry, and the modeling program SAAMII was used to estimate the fractional catabolic rate (FCR) of apoB. Mean LDL-apoB plasma concentrations were almost identical in both groups (HD: 95+/-30 mg/dL, controls: 91+/-40 mg/dL), whereas LDL-apoB FCR was 50% lower in HD patients as compared with controls (0.22+/-0.12 days(-1) versus 0.46+/-0.20 days(-1), P=0.001) with concomitantly decreased production rates of LDL. Compared with controls, intermediate-density lipoprotein (IDL)-apoB FCR was 65% lower (2.87+/-1.02 days(-1) versus 8.89+/-4.94 days(-1), P=0.014), accompanied by 1.5-fold higher IDL-apoB levels in HD. Very low-density lipoprotein metabolism was similar in both study groups.

CONCLUSIONS

In vivo catabolism of LDL and IDL is severely impaired in HD patients but misleadingly masked by normal plasma cholesterol levels. The resulting markedly prolonged residence times of both IDL and LDL particles might thus significantly contribute to the well-documented high risk for premature cardiovascular disease in HD patients.

Authors+Show Affiliations

Division of Cardiology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16195474

Citation

Ikewaki, Katsunori, et al. "Delayed in Vivo Catabolism of Intermediate-density Lipoprotein and Low-density Lipoprotein in Hemodialysis Patients as Potential Cause of Premature Atherosclerosis." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 25, no. 12, 2005, pp. 2615-22.
Ikewaki K, Schaefer JR, Frischmann ME, et al. Delayed in vivo catabolism of intermediate-density lipoprotein and low-density lipoprotein in hemodialysis patients as potential cause of premature atherosclerosis. Arterioscler Thromb Vasc Biol. 2005;25(12):2615-22.
Ikewaki, K., Schaefer, J. R., Frischmann, M. E., Okubo, K., Hosoya, T., Mochizuki, S., ... Dieplinger, H. (2005). Delayed in vivo catabolism of intermediate-density lipoprotein and low-density lipoprotein in hemodialysis patients as potential cause of premature atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 25(12), pp. 2615-22.
Ikewaki K, et al. Delayed in Vivo Catabolism of Intermediate-density Lipoprotein and Low-density Lipoprotein in Hemodialysis Patients as Potential Cause of Premature Atherosclerosis. Arterioscler Thromb Vasc Biol. 2005;25(12):2615-22. PubMed PMID: 16195474.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Delayed in vivo catabolism of intermediate-density lipoprotein and low-density lipoprotein in hemodialysis patients as potential cause of premature atherosclerosis. AU - Ikewaki,Katsunori, AU - Schaefer,Juergen R, AU - Frischmann,Michael E, AU - Okubo,Keio, AU - Hosoya,Tatsuo, AU - Mochizuki,Seibu, AU - Dieplinger,Benjamin, AU - Trenkwalder,Evi, AU - Schweer,Horst, AU - Kronenberg,Florian, AU - Koenig,Paul, AU - Dieplinger,Hans, Y1 - 2005/09/29/ PY - 2005/10/1/pubmed PY - 2006/1/21/medline PY - 2005/10/1/entrez SP - 2615 EP - 22 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler. Thromb. Vasc. Biol. VL - 25 IS - 12 N2 - OBJECTIVE: Premature cardiovascular disease is the leading cause of death in patients with end-stage renal disease treated by hemodialysis (HD). Low-density lipoprotein (LDL) levels are not generally increased in HD patients, but their LDL metabolism is still poorly understood. We therefore investigated the in vivo metabolism of apoB-containing lipoproteins in two different ethnic populations of HD patients and controls. METHODS AND RESULTS: We performed stable isotope kinetic studies using a primed constant infusion of deuterated leucine in 12 HD patients and 13 healthy controls. Tracer/tracee ratio of apoB was determined by means of gas chromatography/mass spectrometry, and the modeling program SAAMII was used to estimate the fractional catabolic rate (FCR) of apoB. Mean LDL-apoB plasma concentrations were almost identical in both groups (HD: 95+/-30 mg/dL, controls: 91+/-40 mg/dL), whereas LDL-apoB FCR was 50% lower in HD patients as compared with controls (0.22+/-0.12 days(-1) versus 0.46+/-0.20 days(-1), P=0.001) with concomitantly decreased production rates of LDL. Compared with controls, intermediate-density lipoprotein (IDL)-apoB FCR was 65% lower (2.87+/-1.02 days(-1) versus 8.89+/-4.94 days(-1), P=0.014), accompanied by 1.5-fold higher IDL-apoB levels in HD. Very low-density lipoprotein metabolism was similar in both study groups. CONCLUSIONS: In vivo catabolism of LDL and IDL is severely impaired in HD patients but misleadingly masked by normal plasma cholesterol levels. The resulting markedly prolonged residence times of both IDL and LDL particles might thus significantly contribute to the well-documented high risk for premature cardiovascular disease in HD patients. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/16195474/Delayed_in_vivo_catabolism_of_intermediate_density_lipoprotein_and_low_density_lipoprotein_in_hemodialysis_patients_as_potential_cause_of_premature_atherosclerosis_ L2 - http://www.ahajournals.org/doi/full/10.1161/01.ATV.0000188555.60475.c2?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -