Tags

Type your tag names separated by a space and hit enter

Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease?
Gene Ther. 2006 Mar; 13(6):496-502.GT

Abstract

MicroRNAs (miRNAs) are endogenous 19-25 nucleotide RNAs that have recently emerged as a novel class of important gene-regulatory molecules involved in many critical developmental and cellular functions. miRNAs have been implicated in the pathogenesis of several human diseases, such as neurodegenerative disorders, cancer, and more recently in viral and metabolic diseases. Unraveling the roles of miRNAs in cellular processes linked to human diseases will lead to novel opportunities for the regulation of protein function and will help to evaluate their potential for therapeutic intervention. Approaches to interfere with miRNA function in vitro and in vivo based on synthetic anti-miRNA oligonucleotides (AMOs) are discussed in this review.

Authors+Show Affiliations

Weiler J
Novartis Institutes for BioMedical Research, Genome and Proteome Sciences, Basel, Switzerland. jan.weiler@novartis.com
Hunziker J
No affiliation info available
Hall J
No affiliation info available

MeSH

AnimalsGene TargetingGenetic TherapyHumansMicroRNAsNeoplasmsNeurodegenerative DiseasesRNA InterferenceVirus Diseases

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16195701

Citation

Weiler, J, et al. "Anti-miRNA Oligonucleotides (AMOs): Ammunition to Target miRNAs Implicated in Human Disease?" Gene Therapy, vol. 13, no. 6, 2006, pp. 496-502.
Weiler J, Hunziker J, Hall J. Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease? Gene Ther. 2006;13(6):496-502.
Weiler, J., Hunziker, J., & Hall, J. (2006). Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease? Gene Therapy, 13(6), 496-502.
Weiler J, Hunziker J, Hall J. Anti-miRNA Oligonucleotides (AMOs): Ammunition to Target miRNAs Implicated in Human Disease. Gene Ther. 2006;13(6):496-502. PubMed PMID: 16195701.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease? AU - Weiler,J, AU - Hunziker,J, AU - Hall,J, PY - 2005/10/1/pubmed PY - 2006/6/30/medline PY - 2005/10/1/entrez SP - 496 EP - 502 JF - Gene therapy JO - Gene Ther VL - 13 IS - 6 N2 - MicroRNAs (miRNAs) are endogenous 19-25 nucleotide RNAs that have recently emerged as a novel class of important gene-regulatory molecules involved in many critical developmental and cellular functions. miRNAs have been implicated in the pathogenesis of several human diseases, such as neurodegenerative disorders, cancer, and more recently in viral and metabolic diseases. Unraveling the roles of miRNAs in cellular processes linked to human diseases will lead to novel opportunities for the regulation of protein function and will help to evaluate their potential for therapeutic intervention. Approaches to interfere with miRNA function in vitro and in vivo based on synthetic anti-miRNA oligonucleotides (AMOs) are discussed in this review. SN - 0969-7128 UR - https://www.unboundmedicine.com/medline/citation/16195701/Anti_miRNA_oligonucleotides__AMOs_:_ammunition_to_target_miRNAs_implicated_in_human_disease DB - PRIME DP - Unbound Medicine ER -