Tags

Type your tag names separated by a space and hit enter

[Effects of the liposomes coated by chitosan and its derivatives on the gastrointestinal transit of insulin].
Yao Xue Xue Bao. 2005 Jul; 40(7):618-22.YX

Abstract

AIM

To study the effect of the liposomes coated by chitosan and its derivatives as oral dosage form for peptide drugs on the gastrointestinal (GI) transit of drugs.

METHODS

Insulin-liposomes were prepared by reversed-phase evaporation. The in situ perfusion experiment was used to investigate the enteral absorption of insulin. The hypoglycemic effects of insulin were investigated using the glucose oxidase method after administration in rats. The insulin concentrations of serum and enteral tissues were determined by radio-immunoassay in rats.

RESULTS

In in situ local intestinal perfusion experiment, the duodenum was the best segment for the absorption of the insulin liposomes coated by chitosan (CH) or chitosan-EDTA conjugates (CEC) , and double-coated by CH-CEC; the colon was the best segment for the absorption of the insulin solution from rat intestine; but the best segment for the absorption of the uncoated and N-trimethyl chitosan chloride (TMC) coated insulin liposomes was unclear. In all segments, the enteral absorption of the insulin liposomes double-coated by CH-CEC was superior to that of other insulin liposomes.

CONCLUSION

The insulin-liposomes coated by chitosan and its derivatives can enhance enteral absorption of insulin and increase stability of insulin in GI tract.

Authors+Show Affiliations

Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

16196267

Citation

Wu, Zheng-Hong, et al. "[Effects of the Liposomes Coated By Chitosan and Its Derivatives On the Gastrointestinal Transit of Insulin]." Yao Xue Xue Bao = Acta Pharmaceutica Sinica, vol. 40, no. 7, 2005, pp. 618-22.
Wu ZH, Ping QN, Lei XM, et al. [Effects of the liposomes coated by chitosan and its derivatives on the gastrointestinal transit of insulin]. Yao Xue Xue Bao. 2005;40(7):618-22.
Wu, Z. H., Ping, Q. N., Lei, X. M., Li, J. Y., & Cai, P. (2005). [Effects of the liposomes coated by chitosan and its derivatives on the gastrointestinal transit of insulin]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 40(7), 618-22.
Wu ZH, et al. [Effects of the Liposomes Coated By Chitosan and Its Derivatives On the Gastrointestinal Transit of Insulin]. Yao Xue Xue Bao. 2005;40(7):618-22. PubMed PMID: 16196267.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of the liposomes coated by chitosan and its derivatives on the gastrointestinal transit of insulin]. AU - Wu,Zheng-Hong, AU - Ping,Qi-Neng, AU - Lei,Xiao-Min, AU - Li,Jian-Ying, AU - Cai,Peng, PY - 2005/10/4/pubmed PY - 2007/3/3/medline PY - 2005/10/4/entrez SP - 618 EP - 22 JF - Yao xue xue bao = Acta pharmaceutica Sinica JO - Yao Xue Xue Bao VL - 40 IS - 7 N2 - AIM: To study the effect of the liposomes coated by chitosan and its derivatives as oral dosage form for peptide drugs on the gastrointestinal (GI) transit of drugs. METHODS: Insulin-liposomes were prepared by reversed-phase evaporation. The in situ perfusion experiment was used to investigate the enteral absorption of insulin. The hypoglycemic effects of insulin were investigated using the glucose oxidase method after administration in rats. The insulin concentrations of serum and enteral tissues were determined by radio-immunoassay in rats. RESULTS: In in situ local intestinal perfusion experiment, the duodenum was the best segment for the absorption of the insulin liposomes coated by chitosan (CH) or chitosan-EDTA conjugates (CEC) , and double-coated by CH-CEC; the colon was the best segment for the absorption of the insulin solution from rat intestine; but the best segment for the absorption of the uncoated and N-trimethyl chitosan chloride (TMC) coated insulin liposomes was unclear. In all segments, the enteral absorption of the insulin liposomes double-coated by CH-CEC was superior to that of other insulin liposomes. CONCLUSION: The insulin-liposomes coated by chitosan and its derivatives can enhance enteral absorption of insulin and increase stability of insulin in GI tract. SN - 0513-4870 UR - https://www.unboundmedicine.com/medline/citation/16196267/[Effects_of_the_liposomes_coated_by_chitosan_and_its_derivatives_on_the_gastrointestinal_transit_of_insulin]_ DB - PRIME DP - Unbound Medicine ER -