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Bupropion-induced subacute cutaneous lupus erythematosus.
Australas J Dermatol. 2005 Nov; 46(4):266-9.AJ

Abstract

Subacute cutaneous lupus erythematosus is a subset of cutaneous lupus erythematosus with unique immunological and clinical features. The first series of patients found to have drug-induced subacute cutaneous lupus erythemotosus were secondary to hydrochlorothiazide. Since that time, several other drugs have been implicated in the induction of subacute cutaneous lupus erythemotosus. A 44-year-old woman presented with a 9-week history of a mildly pruritic, photosensitive rash that started on her chest. One month prior to her skin outbreak she was started on bupropion for mild depression. She was noted to have multiple annular erythematous plaques on her anterior chest, shoulders, back, arms and face. The patient was advised to stop the bupropion and to start topical tacrolimus, and was encouraged to apply a broad-spectrum sunscreen. Her skin completely cleared within 1 month of initiating this treatment regimen. This case is a unique example of bupropion-induced subacute cutaneous lupus erythemotosus. Our patient exemplifies the necessity of a complete medical history, including current medications, especially when subacute cutaneous lupus erythemotosus is suspected.

Authors+Show Affiliations

Cassis TB
Division of Dermatology, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA.
Callen JP
No affiliation info available

MeSH

AdultAntidepressive Agents, Second-GenerationBupropionDepressionFemaleHumansImmunosuppressive AgentsLupus Erythematosus, CutaneousSunscreening AgentsTacrolimusTreatment Outcome

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16197429

Citation

Cassis, Tamella B., and Jeffrey P. Callen. "Bupropion-induced Subacute Cutaneous Lupus Erythematosus." The Australasian Journal of Dermatology, vol. 46, no. 4, 2005, pp. 266-9.
Cassis TB, Callen JP. Bupropion-induced subacute cutaneous lupus erythematosus. Australas J Dermatol. 2005;46(4):266-9.
Cassis, T. B., & Callen, J. P. (2005). Bupropion-induced subacute cutaneous lupus erythematosus. The Australasian Journal of Dermatology, 46(4), 266-9.
Cassis TB, Callen JP. Bupropion-induced Subacute Cutaneous Lupus Erythematosus. Australas J Dermatol. 2005;46(4):266-9. PubMed PMID: 16197429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bupropion-induced subacute cutaneous lupus erythematosus. AU - Cassis,Tamella B, AU - Callen,Jeffrey P, PY - 2005/10/4/pubmed PY - 2006/2/10/medline PY - 2005/10/4/entrez SP - 266 EP - 9 JF - The Australasian journal of dermatology JO - Australas J Dermatol VL - 46 IS - 4 N2 - Subacute cutaneous lupus erythematosus is a subset of cutaneous lupus erythematosus with unique immunological and clinical features. The first series of patients found to have drug-induced subacute cutaneous lupus erythemotosus were secondary to hydrochlorothiazide. Since that time, several other drugs have been implicated in the induction of subacute cutaneous lupus erythemotosus. A 44-year-old woman presented with a 9-week history of a mildly pruritic, photosensitive rash that started on her chest. One month prior to her skin outbreak she was started on bupropion for mild depression. She was noted to have multiple annular erythematous plaques on her anterior chest, shoulders, back, arms and face. The patient was advised to stop the bupropion and to start topical tacrolimus, and was encouraged to apply a broad-spectrum sunscreen. Her skin completely cleared within 1 month of initiating this treatment regimen. This case is a unique example of bupropion-induced subacute cutaneous lupus erythemotosus. Our patient exemplifies the necessity of a complete medical history, including current medications, especially when subacute cutaneous lupus erythemotosus is suspected. SN - 0004-8380 UR - https://www.unboundmedicine.com/medline/citation/16197429/Bupropion_induced_subacute_cutaneous_lupus_erythematosus_ DB - PRIME DP - Unbound Medicine ER -