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Circadian rhythm of autonomic activity in non diabetic offsprings of type 2 diabetic patients.
Cardiovasc Diabetol. 2005 Oct 01; 4:15.CD

Abstract

The aim of the present study was to evaluate, by heart rate variability (HRV) with 24-hours ECG Holter (HRV), the circadian autonomic activity in offspring of type 2 diabetic subjects and the relation with insulin-resistance.

METHODS

50 Caucasian offsprings of type 2 diabetic subjects were divided in two groups: insulin-resistant offsprings (IR) and non insulin-resistant offsprings (NIR). Autonomic nervous activity was studied by HRV. Time domain and spectral analysis (low frequency, LF, and high frequency, HF, provide markers of sympathetic and parasympathetic modulation when assessed in normalized units) were evaluated.

RESULTS

Time domain showed a reduction of total SDNN in IR (p < 0.001) and NIR (p 0.047) versus controls. Spectral analysis showed a total and night LF higher in IR and NIR than in control group (all p < 0.001).

CONCLUSION

In frequency domain, the analysis of sympathetic (LF) and parasympathetic (HF) component evidenced an association between the offspring of type 2 diabetic subjects and a sympathetic overactivity. A global reduction and alteration of circadian rhythm of autonomic activity are present in offspring of type 2 diabetic patients with and without insulin resistance. The data of our study suggested that an autonomic impairment is associated with the familiarity for type 2 diabetes independently to insulin resistance and that an impairment of autonomic system activity could precede the insulin resistance.

Authors+Show Affiliations

III Clinica Medica, Department of Clinical Medicine, University La Sapienza, Rome, Italy. fiorentini-a@libero.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16197556

Citation

Fiorentini, A, et al. "Circadian Rhythm of Autonomic Activity in Non Diabetic Offsprings of Type 2 Diabetic Patients." Cardiovascular Diabetology, vol. 4, 2005, p. 15.
Fiorentini A, Perciaccante A, Paris A, et al. Circadian rhythm of autonomic activity in non diabetic offsprings of type 2 diabetic patients. Cardiovasc Diabetol. 2005;4:15.
Fiorentini, A., Perciaccante, A., Paris, A., Serra, P., & Tubani, L. (2005). Circadian rhythm of autonomic activity in non diabetic offsprings of type 2 diabetic patients. Cardiovascular Diabetology, 4, 15.
Fiorentini A, et al. Circadian Rhythm of Autonomic Activity in Non Diabetic Offsprings of Type 2 Diabetic Patients. Cardiovasc Diabetol. 2005 Oct 1;4:15. PubMed PMID: 16197556.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circadian rhythm of autonomic activity in non diabetic offsprings of type 2 diabetic patients. AU - Fiorentini,A, AU - Perciaccante,A, AU - Paris,A, AU - Serra,P, AU - Tubani,L, Y1 - 2005/10/01/ PY - 2005/08/01/received PY - 2005/10/01/accepted PY - 2005/10/4/pubmed PY - 2006/4/7/medline PY - 2005/10/4/entrez SP - 15 EP - 15 JF - Cardiovascular diabetology JO - Cardiovasc Diabetol VL - 4 N2 - UNLABELLED: The aim of the present study was to evaluate, by heart rate variability (HRV) with 24-hours ECG Holter (HRV), the circadian autonomic activity in offspring of type 2 diabetic subjects and the relation with insulin-resistance. METHODS: 50 Caucasian offsprings of type 2 diabetic subjects were divided in two groups: insulin-resistant offsprings (IR) and non insulin-resistant offsprings (NIR). Autonomic nervous activity was studied by HRV. Time domain and spectral analysis (low frequency, LF, and high frequency, HF, provide markers of sympathetic and parasympathetic modulation when assessed in normalized units) were evaluated. RESULTS: Time domain showed a reduction of total SDNN in IR (p < 0.001) and NIR (p 0.047) versus controls. Spectral analysis showed a total and night LF higher in IR and NIR than in control group (all p < 0.001). CONCLUSION: In frequency domain, the analysis of sympathetic (LF) and parasympathetic (HF) component evidenced an association between the offspring of type 2 diabetic subjects and a sympathetic overactivity. A global reduction and alteration of circadian rhythm of autonomic activity are present in offspring of type 2 diabetic patients with and without insulin resistance. The data of our study suggested that an autonomic impairment is associated with the familiarity for type 2 diabetes independently to insulin resistance and that an impairment of autonomic system activity could precede the insulin resistance. SN - 1475-2840 UR - https://www.unboundmedicine.com/medline/citation/16197556/Circadian_rhythm_of_autonomic_activity_in_non_diabetic_offsprings_of_type_2_diabetic_patients_ L2 - https://cardiab.biomedcentral.com/articles/10.1186/1475-2840-4-15 DB - PRIME DP - Unbound Medicine ER -