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Putting cardiovascular disease and vitamin D insufficiency into perspective.

Abstract

The aetiology of CVD is still not completely understood. The present review article summarises data supporting the hypothesis that an insufficient vitamin D status may contribute to the worldwide high prevalence of CVD. Human vitamin D status primarily depends on skin exposure to the UVB spectrum of the sunlight. Epidemiological data indicate that geographic latitude, altitude, season, and the place of residence (urban or rural) are associated with CVD mortality. Interestingly, all these factors also have an influence on human UVB exposure and thus on vitamin D status. Several mechanisms might be responsible for a protective role of vitamin D in CVD. These mechanisms include the inhibition of vascular smooth muscle proliferation, the suppression of vascular calcification, the down regulation of pro-inflammatory cytokines, the up regulation of anti-inflammatory cytokines, and the action of vitamin D as a negative endocrine regulator of the renin-angiotensin system. The first intervention trials indicate that vitamin D may suppress cardiovascular risk markers. However, more controlled clinical trials are needed to investigate whether optimal oral vitamin D supplementation is able to reduce CVD morbidity and mortality.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Cardio-Thoracic Surgery, Heart Center North-Rhine Westfalia, Ruhr University of Bochum, Bad Oeynhausen, Germany. azitterman@hdz-nrw.de

    ,

    Source

    The British journal of nutrition 94:4 2005 Oct pg 483-92

    MeSH

    Calcinosis
    Cardiovascular Diseases
    Cytokines
    Environment
    Humans
    Muscle, Smooth, Vascular
    Parathyroid Hormone
    Seasons
    Vitamin D
    Vitamin D Deficiency
    Vitamins

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    16197570

    Citation

    Zittermann, Armin, et al. "Putting Cardiovascular Disease and Vitamin D Insufficiency Into Perspective." The British Journal of Nutrition, vol. 94, no. 4, 2005, pp. 483-92.
    Zittermann A, Schleithoff SS, Koerfer R. Putting cardiovascular disease and vitamin D insufficiency into perspective. Br J Nutr. 2005;94(4):483-92.
    Zittermann, A., Schleithoff, S. S., & Koerfer, R. (2005). Putting cardiovascular disease and vitamin D insufficiency into perspective. The British Journal of Nutrition, 94(4), pp. 483-92.
    Zittermann A, Schleithoff SS, Koerfer R. Putting Cardiovascular Disease and Vitamin D Insufficiency Into Perspective. Br J Nutr. 2005;94(4):483-92. PubMed PMID: 16197570.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Putting cardiovascular disease and vitamin D insufficiency into perspective. AU - Zittermann,Armin, AU - Schleithoff,Stefanie S, AU - Koerfer,Reiner, PY - 2005/10/4/pubmed PY - 2005/12/13/medline PY - 2005/10/4/entrez SP - 483 EP - 92 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 94 IS - 4 N2 - The aetiology of CVD is still not completely understood. The present review article summarises data supporting the hypothesis that an insufficient vitamin D status may contribute to the worldwide high prevalence of CVD. Human vitamin D status primarily depends on skin exposure to the UVB spectrum of the sunlight. Epidemiological data indicate that geographic latitude, altitude, season, and the place of residence (urban or rural) are associated with CVD mortality. Interestingly, all these factors also have an influence on human UVB exposure and thus on vitamin D status. Several mechanisms might be responsible for a protective role of vitamin D in CVD. These mechanisms include the inhibition of vascular smooth muscle proliferation, the suppression of vascular calcification, the down regulation of pro-inflammatory cytokines, the up regulation of anti-inflammatory cytokines, and the action of vitamin D as a negative endocrine regulator of the renin-angiotensin system. The first intervention trials indicate that vitamin D may suppress cardiovascular risk markers. However, more controlled clinical trials are needed to investigate whether optimal oral vitamin D supplementation is able to reduce CVD morbidity and mortality. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/16197570/full_citation L2 - https://www.cambridge.org/core/product/identifier/S0007114505002060/type/journal_article DB - PRIME DP - Unbound Medicine ER -