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Antiperoxidative and antioxidant effects of Casearia esculenta root extract in streptozotocin-induced diabetic rats.
Yale J Biol Med. 2005 Jan; 78(1):15-23.YJ

Abstract

Oxidative stress is currently suggested to play as a pathogenesis in the development of diabetes mellitus. The present study was designed to evaluate the effect of Casearia esculenta root extract on oxidative stress-related parameters in streptozotocin (STZ) -induced diabetic rats. Antidiabetic treatment with C. esculenta root extract (45 days) significantly (p < .05) decreased thiobarbituric acid reactive substances (TBARS) and remarkably improved tissue antioxidants status such as glutathione (GSH), ascorbic acid (vitamin C) and alpha-tocopherol (vitamin E) in liver and kidney of STZ-diabetic rats. In diabetics rats, the activities of enzymatic antioxidants such as superoxide dismutase (SOD, EC 1.11.1.1) catalase (CAT, EC 1.11.1.6) were decreased significantly while the activity of glutathione peroxidase (GPx, EC 1.11.1.9) decreased in the liver and increased in the kidney. The treatment of diabetic rats with C. esculenta root extract over a 45-day period returned these levels close to normal. These results suggest that C. esculenta root extracts exhibit antiperoxidative as well as antioxidant effects in STZ-induced diabetic rats.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Science, Rajah Muthiah Medical College and Hospital, Annamalai University, Annamalainagar, Tamilnadu, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16197726

Citation

Prakasam, A, et al. "Antiperoxidative and Antioxidant Effects of Casearia Esculenta Root Extract in Streptozotocin-induced Diabetic Rats." The Yale Journal of Biology and Medicine, vol. 78, no. 1, 2005, pp. 15-23.
Prakasam A, Sethupathy S, Pugalendi KV. Antiperoxidative and antioxidant effects of Casearia esculenta root extract in streptozotocin-induced diabetic rats. Yale J Biol Med. 2005;78(1):15-23.
Prakasam, A., Sethupathy, S., & Pugalendi, K. V. (2005). Antiperoxidative and antioxidant effects of Casearia esculenta root extract in streptozotocin-induced diabetic rats. The Yale Journal of Biology and Medicine, 78(1), 15-23.
Prakasam A, Sethupathy S, Pugalendi KV. Antiperoxidative and Antioxidant Effects of Casearia Esculenta Root Extract in Streptozotocin-induced Diabetic Rats. Yale J Biol Med. 2005;78(1):15-23. PubMed PMID: 16197726.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiperoxidative and antioxidant effects of Casearia esculenta root extract in streptozotocin-induced diabetic rats. AU - Prakasam,A, AU - Sethupathy,S, AU - Pugalendi,K V, PY - 2005/10/4/pubmed PY - 2006/5/13/medline PY - 2005/10/4/entrez SP - 15 EP - 23 JF - The Yale journal of biology and medicine JO - Yale J Biol Med VL - 78 IS - 1 N2 - Oxidative stress is currently suggested to play as a pathogenesis in the development of diabetes mellitus. The present study was designed to evaluate the effect of Casearia esculenta root extract on oxidative stress-related parameters in streptozotocin (STZ) -induced diabetic rats. Antidiabetic treatment with C. esculenta root extract (45 days) significantly (p < .05) decreased thiobarbituric acid reactive substances (TBARS) and remarkably improved tissue antioxidants status such as glutathione (GSH), ascorbic acid (vitamin C) and alpha-tocopherol (vitamin E) in liver and kidney of STZ-diabetic rats. In diabetics rats, the activities of enzymatic antioxidants such as superoxide dismutase (SOD, EC 1.11.1.1) catalase (CAT, EC 1.11.1.6) were decreased significantly while the activity of glutathione peroxidase (GPx, EC 1.11.1.9) decreased in the liver and increased in the kidney. The treatment of diabetic rats with C. esculenta root extract over a 45-day period returned these levels close to normal. These results suggest that C. esculenta root extracts exhibit antiperoxidative as well as antioxidant effects in STZ-induced diabetic rats. SN - 1551-4056 UR - https://www.unboundmedicine.com/medline/citation/16197726/Antiperoxidative_and_antioxidant_effects_of_Casearia_esculenta_root_extract_in_streptozotocin_induced_diabetic_rats_ DB - PRIME DP - Unbound Medicine ER -