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Delta-9-tetrahydrocannabinol and cannabidiol, but not ondansetron, interfere with conditioned retching reactions elicited by a lithium-paired context in Suncus murinus: An animal model of anticipatory nausea and vomiting.
Physiol Behav 2006; 87(1):66-71PB

Abstract

Chemotherapy patients report not only acute nausea and vomiting during the treatment itself, but also report anticipatory nausea and vomiting upon re-exposure to the cues associated with the treatment. We present a model of anticipatory nausea based on the emetic reactions of the Suncus murinus (musk shrew). Following three pairings of a novel distinctive contextual cue with the emetic effects of an injection of lithium chloride, the context acquired the potential to elicit conditioned retching in the absence of the toxin. The expression of this conditioned retching reaction was completely suppressed by pretreatment with each of the principal cannabinoids found in marijuana, Delta(9)-tetrahydrocannabinol or cannabidiol, at a dose that did not suppress general activity. On the other hand, pretreatment with a dose of ondansetron (a 5-HT(3) antagonist) that interferes with acute vomiting in this species, did not suppress the expression of conditioned retching during re-exposure to the lithium-paired context. These results support anecdotal claims that marijuana, but not ondansetron, may suppress the expression of anticipatory nausea.

Authors+Show Affiliations

Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada N2L 3C5. lparker@wlu.caNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16197970

Citation

Parker, Linda A., et al. "Delta-9-tetrahydrocannabinol and Cannabidiol, but Not Ondansetron, Interfere With Conditioned Retching Reactions Elicited By a Lithium-paired Context in Suncus Murinus: an Animal Model of Anticipatory Nausea and Vomiting." Physiology & Behavior, vol. 87, no. 1, 2006, pp. 66-71.
Parker LA, Kwiatkowska M, Mechoulam R. Delta-9-tetrahydrocannabinol and cannabidiol, but not ondansetron, interfere with conditioned retching reactions elicited by a lithium-paired context in Suncus murinus: An animal model of anticipatory nausea and vomiting. Physiol Behav. 2006;87(1):66-71.
Parker, L. A., Kwiatkowska, M., & Mechoulam, R. (2006). Delta-9-tetrahydrocannabinol and cannabidiol, but not ondansetron, interfere with conditioned retching reactions elicited by a lithium-paired context in Suncus murinus: An animal model of anticipatory nausea and vomiting. Physiology & Behavior, 87(1), pp. 66-71.
Parker LA, Kwiatkowska M, Mechoulam R. Delta-9-tetrahydrocannabinol and Cannabidiol, but Not Ondansetron, Interfere With Conditioned Retching Reactions Elicited By a Lithium-paired Context in Suncus Murinus: an Animal Model of Anticipatory Nausea and Vomiting. Physiol Behav. 2006 Jan 30;87(1):66-71. PubMed PMID: 16197970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Delta-9-tetrahydrocannabinol and cannabidiol, but not ondansetron, interfere with conditioned retching reactions elicited by a lithium-paired context in Suncus murinus: An animal model of anticipatory nausea and vomiting. AU - Parker,Linda A, AU - Kwiatkowska,Magdalena, AU - Mechoulam,Raphael, Y1 - 2005/09/28/ PY - 2005/05/17/received PY - 2005/07/07/revised PY - 2005/08/25/accepted PY - 2005/10/4/pubmed PY - 2006/3/10/medline PY - 2005/10/4/entrez SP - 66 EP - 71 JF - Physiology & behavior JO - Physiol. Behav. VL - 87 IS - 1 N2 - Chemotherapy patients report not only acute nausea and vomiting during the treatment itself, but also report anticipatory nausea and vomiting upon re-exposure to the cues associated with the treatment. We present a model of anticipatory nausea based on the emetic reactions of the Suncus murinus (musk shrew). Following three pairings of a novel distinctive contextual cue with the emetic effects of an injection of lithium chloride, the context acquired the potential to elicit conditioned retching in the absence of the toxin. The expression of this conditioned retching reaction was completely suppressed by pretreatment with each of the principal cannabinoids found in marijuana, Delta(9)-tetrahydrocannabinol or cannabidiol, at a dose that did not suppress general activity. On the other hand, pretreatment with a dose of ondansetron (a 5-HT(3) antagonist) that interferes with acute vomiting in this species, did not suppress the expression of conditioned retching during re-exposure to the lithium-paired context. These results support anecdotal claims that marijuana, but not ondansetron, may suppress the expression of anticipatory nausea. SN - 0031-9384 UR - https://www.unboundmedicine.com/medline/citation/16197970/Delta_9_tetrahydrocannabinol_and_cannabidiol_but_not_ondansetron_interfere_with_conditioned_retching_reactions_elicited_by_a_lithium_paired_context_in_Suncus_murinus:_An_animal_model_of_anticipatory_nausea_and_vomiting_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9384(05)00378-1 DB - PRIME DP - Unbound Medicine ER -