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Bereavement and marriage are associated with antibody response to influenza vaccination in the elderly.

Abstract

Stressful life events exposure including bereavement, an event commonly experienced by elderly people, social support, marital status, and satisfaction were examined in relation to antibody response to the annual trivalent influenza vaccination in an elderly community sample (N=184). Antibody response was assessed at baseline, and at 1 and 12 months following vaccination. Taking into account baseline antibody titer, overall life events exposure and social support were not associated with response to any of the influenza strains. However, bereavement in the year prior to vaccination was negatively associated with the 1-month response to the A/Panama and B/Shangdong strains. Being married and having higher marital satisfaction was also associated with higher peak responses to the A/Panama influenza strain at 1 month. The positive association between marital satisfaction and A/Panama response was particularly evident in the younger half of the married sample. These associations largely withstood adjustment for potential confounders. Thus, in the elderly, peak antibody response was associated with bereavement and marriage, and not the more general factors, life events and social support, related to antibody response in student samples. This suggests the importance of taking a life course approach to examining relationships between psychosocial factors and immunity, and that interventions to modify the impact of these factors should address those most salient for each age group.

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  • Authors+Show Affiliations

    ,

    School of Sport and Exercise Sciences, University of Birmingham, UK. A.C.Phillips@bham.ac.uk

    , , , ,

    Source

    Brain, behavior, and immunity 20:3 2006 May pg 279-89

    MeSH

    Aged
    Analysis of Variance
    Antibodies, Viral
    Antibody Formation
    Bereavement
    Chi-Square Distribution
    Female
    Follow-Up Studies
    Geriatric Assessment
    Health Behavior
    Humans
    Influenza A virus
    Influenza B virus
    Influenza Vaccines
    Life Change Events
    Male
    Marital Status
    Psychology
    Reference Values
    Self-Assessment
    Social Support
    Statistics, Nonparametric
    Stress, Psychological
    Vaccination

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16198083

    Citation

    Phillips, Anna C., et al. "Bereavement and Marriage Are Associated With Antibody Response to Influenza Vaccination in the Elderly." Brain, Behavior, and Immunity, vol. 20, no. 3, 2006, pp. 279-89.
    Phillips AC, Carroll D, Burns VE, et al. Bereavement and marriage are associated with antibody response to influenza vaccination in the elderly. Brain Behav Immun. 2006;20(3):279-89.
    Phillips, A. C., Carroll, D., Burns, V. E., Ring, C., Macleod, J., & Drayson, M. (2006). Bereavement and marriage are associated with antibody response to influenza vaccination in the elderly. Brain, Behavior, and Immunity, 20(3), pp. 279-89.
    Phillips AC, et al. Bereavement and Marriage Are Associated With Antibody Response to Influenza Vaccination in the Elderly. Brain Behav Immun. 2006;20(3):279-89. PubMed PMID: 16198083.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Bereavement and marriage are associated with antibody response to influenza vaccination in the elderly. AU - Phillips,Anna C, AU - Carroll,Douglas, AU - Burns,Victoria E, AU - Ring,Christopher, AU - Macleod,John, AU - Drayson,Mark, Y1 - 2005/09/27/ PY - 2005/05/24/received PY - 2005/08/16/revised PY - 2005/08/16/accepted PY - 2005/10/4/pubmed PY - 2006/7/27/medline PY - 2005/10/4/entrez SP - 279 EP - 89 JF - Brain, behavior, and immunity JO - Brain Behav. Immun. VL - 20 IS - 3 N2 - Stressful life events exposure including bereavement, an event commonly experienced by elderly people, social support, marital status, and satisfaction were examined in relation to antibody response to the annual trivalent influenza vaccination in an elderly community sample (N=184). Antibody response was assessed at baseline, and at 1 and 12 months following vaccination. Taking into account baseline antibody titer, overall life events exposure and social support were not associated with response to any of the influenza strains. However, bereavement in the year prior to vaccination was negatively associated with the 1-month response to the A/Panama and B/Shangdong strains. Being married and having higher marital satisfaction was also associated with higher peak responses to the A/Panama influenza strain at 1 month. The positive association between marital satisfaction and A/Panama response was particularly evident in the younger half of the married sample. These associations largely withstood adjustment for potential confounders. Thus, in the elderly, peak antibody response was associated with bereavement and marriage, and not the more general factors, life events and social support, related to antibody response in student samples. This suggests the importance of taking a life course approach to examining relationships between psychosocial factors and immunity, and that interventions to modify the impact of these factors should address those most salient for each age group. SN - 0889-1591 UR - https://www.unboundmedicine.com/medline/citation/16198083/Bereavement_and_marriage_are_associated_with_antibody_response_to_influenza_vaccination_in_the_elderly_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889-1591(05)00142-X DB - PRIME DP - Unbound Medicine ER -