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Paediatric eosinophilic oesophagitis: towards early diagnosis and best treatment.
Dig Liver Dis 2006; 38(4):245-51DL

Abstract

Eosinophilic oesophagitis is an emerging disease, well known also in paediatric age, probably caused by both IgE and non-IgE mediated food allergies, diagnosed by upper endoscopy with biopsy. The most severe complication is oesophageal stenosis. The identification of the offending allergens is often difficult; therapy is focused to eliminate the supposed antigenic stimulus, to control the acute symptoms and to induce long-term remission.

AIM

We report the clinical outcome and the typical endoscopic findings of children and adolescents affected by eosinophilic oesophagitis, referring a proposal of diagnostic and treatment protocol.

PATIENTS AND METHODS

Twelve patients, affected by eosinophilic oesophagitis with a histological diagnosis, underwent radiographic upper gastro-intestinal series, 24 h pH-probe and standardised allergic testing; they were treated with steroids (oral prednisone and swallowed aerosolised fluticasone) and elimination diet. Dilations were performed when eosinophilic oesophagitis was not yet diagnosed, or in patients resistant to conventional treatment.

RESULTS

Two patients were lost to follow up (mean follow up: 1 year 11 months); seven patients have no symptoms and normal histology, five of them on restricted diet (without cow's milk protein) and two patients on elemental diet (amino acid formula). In two patients (no allergens identified), mild dysphagia and eosinophilic infiltration persist; one patients underwent Nissen fundoplication for Barrett's oesophagus: he has no symptoms and normal oesophagus, on restricted diet (without cow's milk/eggs protein and wheat).

CONCLUSION

The recognition of typical endoscopic picture with careful biopsies extended to the whole oesophagus, even in emergency, could more quickly lead to the correct diagnosis and avoid severe complications of eosinophilic oesophagitis in children, as stricture and failure to growth. Elimination diet is the key of resolution when the allergens are identified. A great challenge remains the relation between gastro-oesophageal reflux disease and eosinophilic oesophagitis, which should however be explained.

Authors+Show Affiliations

Digestive Surgery and Endoscopic Unit, Pediatric Hospital Bambino Gesu, Piazza S. Onofrio, 4, IRCCS, 00189 Rome, Italy. paola.deangelis@opbg.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16198647

Citation

De Angelis, P, et al. "Paediatric Eosinophilic Oesophagitis: Towards Early Diagnosis and Best Treatment." Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, vol. 38, no. 4, 2006, pp. 245-51.
De Angelis P, Markowitz JE, Torroni F, et al. Paediatric eosinophilic oesophagitis: towards early diagnosis and best treatment. Dig Liver Dis. 2006;38(4):245-51.
De Angelis, P., Markowitz, J. E., Torroni, F., Caldaro, T., Pane, A., Morino, G., ... Dall'Oglio, L. (2006). Paediatric eosinophilic oesophagitis: towards early diagnosis and best treatment. Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 38(4), pp. 245-51.
De Angelis P, et al. Paediatric Eosinophilic Oesophagitis: Towards Early Diagnosis and Best Treatment. Dig Liver Dis. 2006;38(4):245-51. PubMed PMID: 16198647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paediatric eosinophilic oesophagitis: towards early diagnosis and best treatment. AU - De Angelis,P, AU - Markowitz,J E, AU - Torroni,F, AU - Caldaro,T, AU - Pane,A, AU - Morino,G, AU - Wietrzykowska,R Sforza, AU - di Abriola,G Federici, AU - Ponticelli,A, AU - Dall'Oglio,L, Y1 - 2005/09/29/ PY - 2005/04/06/received PY - 2005/07/27/revised PY - 2005/08/29/accepted PY - 2005/10/4/pubmed PY - 2006/10/13/medline PY - 2005/10/4/entrez SP - 245 EP - 51 JF - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver JO - Dig Liver Dis VL - 38 IS - 4 N2 - UNLABELLED: Eosinophilic oesophagitis is an emerging disease, well known also in paediatric age, probably caused by both IgE and non-IgE mediated food allergies, diagnosed by upper endoscopy with biopsy. The most severe complication is oesophageal stenosis. The identification of the offending allergens is often difficult; therapy is focused to eliminate the supposed antigenic stimulus, to control the acute symptoms and to induce long-term remission. AIM: We report the clinical outcome and the typical endoscopic findings of children and adolescents affected by eosinophilic oesophagitis, referring a proposal of diagnostic and treatment protocol. PATIENTS AND METHODS: Twelve patients, affected by eosinophilic oesophagitis with a histological diagnosis, underwent radiographic upper gastro-intestinal series, 24 h pH-probe and standardised allergic testing; they were treated with steroids (oral prednisone and swallowed aerosolised fluticasone) and elimination diet. Dilations were performed when eosinophilic oesophagitis was not yet diagnosed, or in patients resistant to conventional treatment. RESULTS: Two patients were lost to follow up (mean follow up: 1 year 11 months); seven patients have no symptoms and normal histology, five of them on restricted diet (without cow's milk protein) and two patients on elemental diet (amino acid formula). In two patients (no allergens identified), mild dysphagia and eosinophilic infiltration persist; one patients underwent Nissen fundoplication for Barrett's oesophagus: he has no symptoms and normal oesophagus, on restricted diet (without cow's milk/eggs protein and wheat). CONCLUSION: The recognition of typical endoscopic picture with careful biopsies extended to the whole oesophagus, even in emergency, could more quickly lead to the correct diagnosis and avoid severe complications of eosinophilic oesophagitis in children, as stricture and failure to growth. Elimination diet is the key of resolution when the allergens are identified. A great challenge remains the relation between gastro-oesophageal reflux disease and eosinophilic oesophagitis, which should however be explained. SN - 1590-8658 UR - https://www.unboundmedicine.com/medline/citation/16198647/Paediatric_eosinophilic_oesophagitis:_towards_early_diagnosis_and_best_treatment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1590-8658(05)00367-1 DB - PRIME DP - Unbound Medicine ER -