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Bone area and bone mineral content deficits in children with sickle cell disease.
Pediatrics. 2005 Oct; 116(4):943-9.Ped

Abstract

OBJECTIVE

Children with sickle cell disease (SCD) experience poor growth, altered body composition, and delayed maturation. Deficits in bone mineral content (BMC) and bone area (BA) have not been well characterized. The objectives of this study were to assess whole-body BMC (WBBMC) and WBBA in children with SCD, type SS (SCD-SS), compared with healthy control subjects, adjusted for growth and body composition, and to determine the relationships of WBBMC and WBBA to bone age and hematologic parameters in children with SCD-SS.

METHODS

WBBMC, WBBA, and lean mass were measured by dual-energy x-ray absorptiometry in children who were aged 4 to 19 years. Growth, sexual development, and bone age were assessed. Gender-specific z scores for WBBMC relative to age and height were generated from control data.

RESULTS

Ninety children with SCD-SS and 198 healthy control subjects were evaluated. SCD-SS was associated with poor growth. WBBMC was significantly decreased in SCD-SS compared with control subjects, adjusted for age, height, pubertal status, and lean mass. WBBMC relative to age and WBBMC relative to height z scores were -0.95 +/- 0.99 and -0.54 +/- 0.97, respectively, and were associated with hemoglobin and hematocrit levels and history of delayed bone age.

CONCLUSIONS

Children with SCD-SS have significant deficits in WBBMC that persist despite adjustment for poor growth and decreased lean mass. These children may be at increased risk for fragility fractures and suboptimal peak bone mass.

Authors+Show Affiliations

Division of Gastroenterology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16199706

Citation

Buison, Anne M., et al. "Bone Area and Bone Mineral Content Deficits in Children With Sickle Cell Disease." Pediatrics, vol. 116, no. 4, 2005, pp. 943-9.
Buison AM, Kawchak DA, Schall JI, et al. Bone area and bone mineral content deficits in children with sickle cell disease. Pediatrics. 2005;116(4):943-9.
Buison, A. M., Kawchak, D. A., Schall, J. I., Ohene-Frempong, K., Stallings, V. A., Leonard, M. B., & Zemel, B. S. (2005). Bone area and bone mineral content deficits in children with sickle cell disease. Pediatrics, 116(4), 943-9.
Buison AM, et al. Bone Area and Bone Mineral Content Deficits in Children With Sickle Cell Disease. Pediatrics. 2005;116(4):943-9. PubMed PMID: 16199706.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone area and bone mineral content deficits in children with sickle cell disease. AU - Buison,Anne M, AU - Kawchak,Deborah A, AU - Schall,Joan I, AU - Ohene-Frempong,Kwaku, AU - Stallings,Virginia A, AU - Leonard,Mary B, AU - Zemel,Babette S, PY - 2005/10/4/pubmed PY - 2005/12/29/medline PY - 2005/10/4/entrez SP - 943 EP - 9 JF - Pediatrics JO - Pediatrics VL - 116 IS - 4 N2 - OBJECTIVE: Children with sickle cell disease (SCD) experience poor growth, altered body composition, and delayed maturation. Deficits in bone mineral content (BMC) and bone area (BA) have not been well characterized. The objectives of this study were to assess whole-body BMC (WBBMC) and WBBA in children with SCD, type SS (SCD-SS), compared with healthy control subjects, adjusted for growth and body composition, and to determine the relationships of WBBMC and WBBA to bone age and hematologic parameters in children with SCD-SS. METHODS: WBBMC, WBBA, and lean mass were measured by dual-energy x-ray absorptiometry in children who were aged 4 to 19 years. Growth, sexual development, and bone age were assessed. Gender-specific z scores for WBBMC relative to age and height were generated from control data. RESULTS: Ninety children with SCD-SS and 198 healthy control subjects were evaluated. SCD-SS was associated with poor growth. WBBMC was significantly decreased in SCD-SS compared with control subjects, adjusted for age, height, pubertal status, and lean mass. WBBMC relative to age and WBBMC relative to height z scores were -0.95 +/- 0.99 and -0.54 +/- 0.97, respectively, and were associated with hemoglobin and hematocrit levels and history of delayed bone age. CONCLUSIONS: Children with SCD-SS have significant deficits in WBBMC that persist despite adjustment for poor growth and decreased lean mass. These children may be at increased risk for fragility fractures and suboptimal peak bone mass. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/16199706/Bone_area_and_bone_mineral_content_deficits_in_children_with_sickle_cell_disease_ L2 - https://publications.aap.org/pediatrics/article-lookup/doi/10.1542/peds.2004-2582 DB - PRIME DP - Unbound Medicine ER -