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Characterizing behavioral and cognitive dysexecutive changes in progressive supranuclear palsy.
Mov Disord. 2006 Feb; 21(2):199-207.MD

Abstract

Frontal lobe dysfunction is a prominent feature of many neurological disorders. Early diagnosis may be enhanced by establishing a profile of cognitive, behavioral, and emotional change. Traditional psychometric assessment focuses on cognitive dysfunction and fails to identify behavioral changes, particularly those associated with orbitofrontal dysfunction. We examined progressive supranuclear palsy (PSP), a prototypical subcortical dementia with frontal features, using commonly available neuropsychological measures and a modification of the Katz Adjustment Scale-Relatives (KAS-R), an instrument first developed to assess dysexecutive changes in head-injured patients. Executive tests identified deficits in reasoning, planning, set shifting, verbal fluency, information processing speed, and response initiation. On the KAS-R, changes in apathy, social withdrawal, and independence were observed, with little change in belligerence, social irresponsibility, uncooperativeness, obstreperousness, anxiety, and depression. The results show the potential utility of this instrument in characterizing behavioral and emotional changes associated with frontal lobe dysfunction in neurodegenerative disease.

Authors+Show Affiliations

Clinical Psychology, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom. david.millar@nap.nhs.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16200534

Citation

Millar, David, et al. "Characterizing Behavioral and Cognitive Dysexecutive Changes in Progressive Supranuclear Palsy." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 21, no. 2, 2006, pp. 199-207.
Millar D, Griffiths P, Zermansky AJ, et al. Characterizing behavioral and cognitive dysexecutive changes in progressive supranuclear palsy. Mov Disord. 2006;21(2):199-207.
Millar, D., Griffiths, P., Zermansky, A. J., & Burn, D. J. (2006). Characterizing behavioral and cognitive dysexecutive changes in progressive supranuclear palsy. Movement Disorders : Official Journal of the Movement Disorder Society, 21(2), 199-207.
Millar D, et al. Characterizing Behavioral and Cognitive Dysexecutive Changes in Progressive Supranuclear Palsy. Mov Disord. 2006;21(2):199-207. PubMed PMID: 16200534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterizing behavioral and cognitive dysexecutive changes in progressive supranuclear palsy. AU - Millar,David, AU - Griffiths,Philipa, AU - Zermansky,Adam J, AU - Burn,David J, PY - 2005/10/4/pubmed PY - 2006/9/26/medline PY - 2005/10/4/entrez SP - 199 EP - 207 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 21 IS - 2 N2 - Frontal lobe dysfunction is a prominent feature of many neurological disorders. Early diagnosis may be enhanced by establishing a profile of cognitive, behavioral, and emotional change. Traditional psychometric assessment focuses on cognitive dysfunction and fails to identify behavioral changes, particularly those associated with orbitofrontal dysfunction. We examined progressive supranuclear palsy (PSP), a prototypical subcortical dementia with frontal features, using commonly available neuropsychological measures and a modification of the Katz Adjustment Scale-Relatives (KAS-R), an instrument first developed to assess dysexecutive changes in head-injured patients. Executive tests identified deficits in reasoning, planning, set shifting, verbal fluency, information processing speed, and response initiation. On the KAS-R, changes in apathy, social withdrawal, and independence were observed, with little change in belligerence, social irresponsibility, uncooperativeness, obstreperousness, anxiety, and depression. The results show the potential utility of this instrument in characterizing behavioral and emotional changes associated with frontal lobe dysfunction in neurodegenerative disease. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/16200534/Characterizing_behavioral_and_cognitive_dysexecutive_changes_in_progressive_supranuclear_palsy_ L2 - https://doi.org/10.1002/mds.20707 DB - PRIME DP - Unbound Medicine ER -